Has output: Difference between revisions

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Back to [http://wiki.geneontology.org/index.php/Annotation_usage_examples_for_each_annotation_extension_relation  Annotation usage examples for each annotation extension relation]
==Definition==
==Definition==


p has_output c if c participates_in p at the end of p and c is in some way changed by p or created by p.
Identifies an entity that is changed or created after participation in a molecular function or biological process.
 
==Comment==
 
[http://wiki.geneontology.org/index.php/Annotation_Extension_Relation:has_participant#Comment '''More details on the limited use of has_output with biological process annotations''']


==Child terms==
==Child terms==
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===Domain===
===Domain===


BFO:0000007 ! process (Biological Process or Molecular Function)  
GO:0008150 ! process (Biological Process)


===Range===
===Range===
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==Annotation Extension Usage Examples==
==Annotation Extension Usage Examples==


'''Product of enzyme activity'''
'''1. FGF production in response to stimulation of protein A'''  
 
Statement from paper: 
 
''Hypoxia significantly induced PGIS expression in highly vascularized tissues, including lung, brain, and kidney (Fig. 9A). Additionally, plasma levels of 6-oxo-PGF1α were significantly increased (about 2-fold) in mice exposed to hypoxia (Fig. 9B). These findings demonstrate that hypoxia stimulates the release of PGI2 in vivo and support the contribution of vascular PGIS to this effect.''




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! Annotation Extension (col 16)
! Annotation Extension (col 16)
|-
|-
| Q16647
| Pxxxx
|GO:0008116 <span style="color:green">prostaglandin-I synthase activity</span>
|Protein A
| PMID:21296955
|GO:0090269 <span style="color:green">fibroblast growth factor production</span>
| IDA
|PMID:xxx
|
|has_output (UniProt:Q9GZV9 <span style="color:green">FGF23</span>)
has_output(ChEBI:15552 <span style="color:green">prostaglandin I2</span>)
|
 
|}
 
== Using examples to demonstrate [[Folding_and_Unfolding]] using the relationship has_output ==
 
'''1. FGF production in response to stimulation of protein A'''


{| class="wikitable" border="1"
! Folded/unfolded
!DB (Col 2)
!Object (Col 3)
!GO ID (Col 5)
!Reference (Col 6)
!Extension (Col 16)
!Parent terms for new folded GO term
|-
| Unfolded
| Pxxxx
|Protein A
|GO:0090269 <span style="color:green">fibroblast growth factor production</span>
|PMID:xxx
|has_output (UniProt:Q9GZV9 <span style="color:green">FGF23</span>)
|
|-
| Folded
| Pxxxx
|Protein A
|New GO term <span style="color:green">FGF23 fibroblast growth factor cytokine production</span>
|PMID:xxx
|
|is_a GO:0090269 <span style="color:red">fibroblast growth factor production</span>
|-
|}
|}
'''OWL class expression:''' GO:0090269 <span style="color:red">fibroblast growth factor production</span> AND has_output SOME UniProt:Q9GZV9 <span style="color:red">FGF23</span>
----
----
----


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[[Category:relations]]
[[Category:relations]]
[[Category:annotation extension]]
[[Category:annotation extension]]
[[Category: GO-CAM Relations]]

Revision as of 11:53, 13 April 2019

Back to Annotation usage examples for each annotation extension relation

Definition

Identifies an entity that is changed or created after participation in a molecular function or biological process.

Comment

More details on the limited use of has_output with biological process annotations

Child terms

  • None

Scope of use

Domain

GO:0008150 ! process (Biological Process)

Range

ENTITY_UNION:0000005 ! chemical, gene product, or complex

Annotation Extension Usage Examples

1. FGF production in response to stimulation of protein A


Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16)
Pxxxx Protein A GO:0090269 fibroblast growth factor production PMID:xxx has_output (UniProt:Q9GZV9 FGF23)

Using examples to demonstrate Folding_and_Unfolding using the relationship has_output

1. FGF production in response to stimulation of protein A

Folded/unfolded DB (Col 2) Object (Col 3) GO ID (Col 5) Reference (Col 6) Extension (Col 16) Parent terms for new folded GO term
Unfolded Pxxxx Protein A GO:0090269 fibroblast growth factor production PMID:xxx has_output (UniProt:Q9GZV9 FGF23)
Folded Pxxxx Protein A New GO term FGF23 fibroblast growth factor cytokine production PMID:xxx is_a GO:0090269 fibroblast growth factor production

OWL class expression: GO:0090269 fibroblast growth factor production AND has_output SOME UniProt:Q9GZV9 FGF23




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