Has output

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Definition

Identifies an entity that is changed or created after participation in a molecular function or biological process.

Child terms

  • None

Scope of use

Domain

BFO:0000007 ! process (Biological Process or Molecular Function)

Range

ENTITY_UNION:0000005 ! chemical, gene product, or complex

Annotation Extension Usage Examples

1. Product of catalytic activity

Statement from paper:

Hypoxia significantly induced PGIS expression in highly vascularized tissues, including lung, brain, and kidney (Fig. 9A). Additionally, plasma levels of 6-oxo-PGF1α were significantly increased (about 2-fold) in mice exposed to hypoxia (Fig. 9B). These findings demonstrate that hypoxia stimulates the release of PGI2 in vivo and support the contribution of vascular PGIS to this effect.


Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16)
Q16647 GO:0008116 prostaglandin-I synthase activity PMID:21296955 IDA

has_output(CHEBI:15552 prostaglandin I2)

2. Abnormal G-CSF and chemokine production in the G6PT-deficient mice

Statement from paper:

The neutropenia and stimulation of myelopoiesis in G6PT−/− mice suggest that G-CSF (20,21) levels might be elevated. During the first 2–3 weeks, when neutropenia is most severe and the elevation in CFU-G is highest, the plasma G-CSF level in G6PT−/− mice is elevated to 17 263±4917 pg/ml, compared with 10±7 pg/ml in the G6PT+/+ or G6PT+/− mice (Fig. 5A). After weaning, with the improvement in neutropenia and decline in overproduction of CFU-G, the plasma G-CSF level in G6PT-deficient mice drops significantly. However, even at 22 weeks of age, the plasma G-CSF in the G6PT−/− mice remains 12-fold higher than age-matched controls (Fig. 5A), suggesting an underlying problem with neutrophil production.


Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16)
Q16647 GO:0008116 prostaglandin-I synthase activity PMID:21296955 IDA

has_output(CHEBI:15552 prostaglandin I2)




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