Has output

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Definition

Identifies an entity that is changed or created after participation in a molecular function or biological process.

Child terms

  • None

Scope of use

Domain

BFO:0000007 ! process (Biological Process or Molecular Function)

Range

ENTITY_UNION:0000005 ! chemical, gene product, or complex

Annotation Extension Usage Examples

1. Product of catalytic activity

Statement from paper:

Hypoxia significantly induced PGIS expression in highly vascularized tissues, including lung, brain, and kidney (Fig. 9A). Additionally, plasma levels of 6-oxo-PGF1α were significantly increased (about 2-fold) in mice exposed to hypoxia (Fig. 9B). These findings demonstrate that hypoxia stimulates the release of PGI2 in vivo and support the contribution of vascular PGIS to this effect.


Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16)
Q16647 Prostacyclin synthase GO:0008116 prostaglandin-I synthase activity PMID:21296955 IDA

has_output(CHEBI:15552 prostaglandin I2)

2. Abnormal G-CSF and chemokine production in G6PT-deficient mice

Statement from paper:

The neutropenia and stimulation of myelopoiesis in G6PT−/− mice suggest that G-CSF (20,21) levels might be elevated. During the first 2–3 weeks, when neutropenia is most severe and the elevation in CFU-G is highest, the plasma G-CSF level in G6PT−/− mice is elevated to 17 263±4917 pg/ml, compared with 10±7 pg/ml in the G6PT+/+ or G6PT+/− mice (Fig. 5A). After weaning, with the improvement in neutropenia and decline in overproduction of CFU-G, the plasma G-CSF level in G6PT-deficient mice drops significantly. However, even at 22 weeks of age, the plasma G-CSF in the G6PT−/− mice remains 12-fold higher than age-matched controls (Fig. 5A), suggesting an underlying problem with neutrophil production.


Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16)
MGI:1316650 Putative glycogen storage disease type 1b protein GO:0001816 cytokine production PMID:12925567 IMP has_output(MGI:1339751 Granulocyte colony-stimulating factor)

Using examples to demonstrate Folding_and_Unfolding using the relationship has_output

1. Product of catalytic activity, PMID:21296955

Folded/unfolded DB (Col 2) Object (Col 3) GO ID (Col 5) Reference (Col 6) Extension (Col 16) Parent terms for new folded GO term
Unfolded Q16647 Prostacyclin synthase GO:0008116 prostaglandin-I synthase activity PMID:21296955 has_output (CHEBI:15552 prostaglandin I2)
Folded Q16647 Prostacyclin synthase New GO term prostaglandin I2 synthase activity PMID:21296955 is_a GO:0008116 prostaglandin-I synthase activity

2. Abnormal G-CSF and chemokine production in G6PT-deficient mice, PMID:12925567

Folded/unfolded DB (Col 2) Object (Col 3) GO ID (Col 5) Reference (Col 6) Extension (Col 16) Parent terms for new folded GO term
Unfolded MGI:1316650 Putative glycogen storage disease type 1b protein GO:0001816 cytokine production PMID:12925567 has_output (MGI:1339751 Granulocyte colony-stimulating factor)
Folded MGI:1316650 Putative glycogen storage disease type 1b protein GO:0001816 cytokine production PMID:12925567 No new GO term created



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