Has output

Definition

Identifies an entity that is changed or created after participation in a molecular function or biological process.

Child terms

None

Scope of use

Domain

GO:0008150 ! process (Biological Process)

Range

ENTITY_UNION:0000005 ! chemical, gene product, or complex

Annotation Extension Usage Examples

1. Abnormal G-CSF and chemokine production in G6PT-deficient mice

Statement from paper:

The neutropenia and stimulation of myelopoiesis in G6PT−/− mice suggest that G-CSF (20,21) levels might be elevated. During the first 2–3 weeks, when neutropenia is most severe and the elevation in CFU-G is highest, the plasma G-CSF level in G6PT−/− mice is elevated to 17 263±4917 pg/ml, compared with 10±7 pg/ml in the G6PT+/+ or G6PT+/− mice (Fig. 5A). After weaning, with the improvement in neutropenia and decline in overproduction of CFU-G, the plasma G-CSF level in G6PT-deficient mice drops significantly. However, even at 22 weeks of age, the plasma G-CSF in the G6PT−/− mice remains 12-fold higher than age-matched controls (Fig. 5A), suggesting an underlying problem with neutrophil production.

Gene Name (col 2)	GO ID (col 5)	Reference (col 6)	Evidence (col 7)	Annotation Extension (col 16)
MGI:1316650 Putative glycogen storage disease type 1b protein	GO:0001816 cytokine production	PMID:12925567	IMP	has_output(MGI:1339751 Granulocyte colony-stimulating factor)

Using examples to demonstrate Folding_and_Unfolding using the relationship has_output

1. Abnormal G-CSF and chemokine production in G6PT-deficient mice, PMID:12925567

Folded/unfolded	DB (Col 2)	Object (Col 3)	GO ID (Col 5)	Reference (Col 6)	Extension (Col 16)	Parent terms for new folded GO term
Unfolded	Pxxxx	Protein A	GO:0090269 fibroblast growth factor production	PMID:xxx	has_output (UniProt:Q9GZV9 FGF23)
Folded	Pxxxx	Protein A	New GO term FGF23 fibroblast growth factor cytokine production	PMID:xxx		GO:0090269 fibroblast growth factor production

Back to Annotation usage examples for each annotation extension relation