Annotation Extension Relation:has regulation target
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Definition
Identifies a gene or gene product affected by a regulation Biological Process or regulator Molecular Function.
Comment
Child terms
- None
Scope of use
Domain
GO:0065007 ! biological regulation
Range
ENTITY_UNION:0000005 ! chemical, gene product or complex
Annotation Extension Usage Examples
Loss of transcription factor activity affects gene expression:
Statements from paper:
Indeed, LGG-1 was massively upregulated in atf-2(tm467) mutant embryos, as compared with the wild type (Fig. 6A). We observed a similar extent of BEC-1 upregulation in the atf-2-deficient background (data not shown).
Expressed in LEGO: http://go-genkisugi.rhcloud.com/seed/model/gomodel:taxon_6239-548253760000031
| Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) |
|---|---|---|---|---|
| WBGene00000220 atf-2(tm467) | GO:0000122 negative regulation of transcription from RNA polymerase II promoter | PMID:21502138 | IMP | has_regulation_target(WB:WBGene00000247 bec-1) 'pipe' has_regulation_target(WB:WBGene00002980 lgg-1 |
Using examples (from above) to demonstrate Folding_and_Unfolding using the relationship has_regulation_target
Specifying the gene which is a target of a transcription factor
gene transcription targets
Statement example:
Indeed, LGG-1 was massively upregulated in atf-2(tm467) mutant embryos, as compared with the wild type (Fig. 6A). We observed a similar extent of BEC-1 upregulation in the atf-2-deficient background (data not shown).
| Folded/unfolded | Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) | Parent terms of new folded GO term |
|---|---|---|---|---|---|---|
| Unfolded | WBGene00000220 atf-2(tm467) | GO:0000122 negative regulation of transcription from RNA polymerase II promoter | PMID:21502138 | IMP | has_regulation_target(WB:WBGene00000247 bec-1)'pipe' has_regulation_target(WB:WBGene00002980 lgg-1 | |
| Folded | WBGene00000220 atf-2(tm467) | GO:0000122 negative regulation of transcription from RNA polymerase II promoter | PMID:21502138 | IMP | No new GO term created |
OWL class expression: GO:0000122 negative regulation of transcription from RNA polymerase II promoter AND has_regulation_target SOME WB:WBGene00000247 bec-1 OWL class expression: GO:0000122 negative regulation of transcription from RNA polymerase II promoter AND has_regulation_target SOME WB:WBGene00002980 lgg-1
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