Annotation Extension Relation Documentation Jamboree
Documentation pages
http://wiki.geneontology.org/index.php/Folding_and_Unfolding
Issues arising
Folded/Unfolded annotations
1. has_input relationship would annotations like these ever be folded?
DB (Col 2) | Object (Col 3) | GO ID (Col 5) | Reference (Col 6) | Evidence (Col 7) | Extension (Col 16) |
---|---|---|---|---|---|
Q8WY54 | PPM1E | GO:0035690 cellular response to drugs | PMID:20801214 | IDA | has_input(CHEBI:6801 metformin) |
O14672 | ADAM10 | GO:0006509 membrane protein ectodomain proteolysis | PMID:18676862 | IMP | has_input(UNIPROT:Q29983 MICA) |
Other
1. acts_on_population_of
Should this be a plural relationship? Pretty much everything else in GO is singular.
2. When to use has_input relationship and when to use has_regulation_target
has_regulation_target is limited to the domain GO:0065007 ! biological regulation
Can has_input be used with the domain GO:0065007 ! biological regulation?
3. requires substance and other similar terms
- requires substance
- Definition: The annotated gene product participates in a Biological Process or executes a Molecular Function only in presence of a substance
- in absence of
- Definition: Identifies a chemical, gene product or complex in the absence of which an ontology term is observed to apply to the annotated gene product.
- in presence of
- Definition: Identifies a chemical, gene product or complex in the presence of which an ontology term is observed to apply to the annotated gene product.
- independent of
- Definition: Identifies an entity that was shown not to be required for the ontology term to apply to the annotated gene product
- activated_by
- inhibited_by
- stabilizes
Not in current QuickGO visualisation page (but on [1]
- modified by
- requires_regulation_by
- requires_direct_regulator
Missing from [2] but present on QuickGO visualisation page
Examples needed
1. has_input
We need an example where the has_input ID is folded to be incorporated into the GO term. Preferably an example other than response to (has_input ID)