View source for CAMP-mediated signaling ; GO:0019933

[[Category:Signaling]]
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==cAMP SIGNALING OVERVIEW==

* liganded-GPCRs signal through G-proteins to either ACTIVATE or INACTIVATE adenylate cyclase (AC)
* Activated adenylate cyclase produces cAMP from ATP
* cAMP goes on to activate e.g. PKA.

For an image, see http://www.springerimages.com/Images/RSS/1-10.1007_s00441-006-0226-0-4

==outstanding questions==

* Where does cAMP signaling start?
** With AC activity?
** Upstream with any signal or signal transducer that signals THROUGH cAMP?

* Does cAMP signaling include signaling both as a result of an INCREASE or a DECREASE in cAMP?



==GO TERMS==

* cAMP-mediated signaling ; GO:0019933
* adenylate cyclase-modulating G-protein coupled receptor signaling pathway ; GO:0007188
* adenylate cyclase activity ; GO:0004016


==SF ITEMS==