CAMP-mediated signaling ; GO:0019933

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cAMP SIGNALING OVERVIEW

• liganded-GPCRs signal through G-proteins to either ACTIVATE or INACTIVATE adenylate cyclase (AC)
• Activated adenylate cyclase produces cAMP from ATP
• cAMP goes on to activate e.g. PKA.

outstanding questions

• Where does cAMP signaling start?
  • With AC activity?
  • Upstream with any signal or signal transducer that signals THROUGH cAMP?

• Does cAMP signaling include signaling both as a result of an INCREASE or a DECREASE in cAMP?

GO TERMS

• cAMP-mediated signaling ; GO:0019933
• adenylate cyclase-modulating G-protein coupled receptor signaling pathway ; GO:0007188
• adenylate cyclase activity ; GO:0004016