Cardiac conduction: Difference between revisions

From GO Wiki
Jump to navigation Jump to search
Line 1: Line 1:
== Venue and date ==
== Venue and date ==
UCL, Possibly Wednesday 9th - Thursday (1/2 day) 10th Nov 2011 (to tie in with Hinxton Genomics meeting and GOC meeting)
UCL, Possibly Thursday 10th and Friday 11th (1/2 day) November 2011 (to tie in with GOC meeting)
 
== Draft Programme ==
 
{| border="1" cellpadding="2" width=1000px
|-valign="top"
|width="5%"|'''9:15am'''
|width="90%"|Coffee and breakfast pastries
|width="5%"|
|-valign="top"
|'''9:30am'''
| Welcome and introduction
|Varsha
|-valign="top"
|'''9:35am'''
|Introduction to GO
|David
|-valign="top"
|'''9:45am'''
|Check terms are applicable across '''[http://tolweb.org/Bilateria/2459 Bilateria]'''<br/>*  heart<br/>*  blood<br/>* vessels<br/>* SF - ''[https://sourceforge.net/tracker/?func=detail&aid=2834270&group_id=36855&atid=440764 blood circulation]''
|Susan
|-valign="top"
|'''10:15am'''
|Cardiac precursor tissues and cells<br/>* Development of primary and secondary heart fields <br/>* cardiac muscle cell specification/differentiation/development <br/>* cardiac endothelial cell specification/differentiation/development <br/>* SF - ''[https://sourceforge.net/tracker/?func=detail&aid=2855625&group_id=36855&atid=440764 symmetry/asymmetry]'',''[https://sourceforge.net/tracker/?func=detail&aid=2855516&group_id=36855&atid=440764 heart field]'', ''[https://sourceforge.net/tracker/?func=detail&aid=2855535&group_id=36855&atid=440764 heart cone]'', ''[https://sourceforge.net/tracker/?func=detail&aid=2855542&group_id=36855&atid=440764 precursor cell differentiation]'', ''[https://sourceforge.net/tracker/?func=detail&aid=2855523&group_id=36855&atid=440764 endocardium]'',
|
|-valign="top"
|'''11am'''
|Coffee break
|
|-valign="top"
|'''11:45am'''
|Cardiac cell migration, Heart morphogenesis<br/>* morphogenic and migratory changes to those cell populations as they move towards formation of the heart tube<br/>*  L/R patterning <br/>* neural crest contribution to the heart<br/>* SF - ''[https://sourceforge.net/tracker/?func=detail&aid=2855632&group_id=36855&atid=440764 cell migration]'', ''[https://sourceforge.net/tracker/?func=detail&aid=2855620&group_id=36855&atid=440764 heart tube]'', ''[https://sourceforge.net/tracker/?func=detail&aid=2855509&group_id=36855&atid=440764 heart looping and jogging]''
|
|-valign="top"
|'''12:30pm'''
|Lunch at Ask on Grafton Way.  ''[http://www.askcentral.co.uk/askmenu.html Menu]''
|
|-valign="top"
|'''2pm'''
|Continue with Cardiac cell migration, Heart morphogenesis
|
|-valign="top"
|'''2:45pm'''
|Heart structure formation<br/>* heart chamber, septum, trabeculae, valves<br/>* SF - ''[https://sourceforge.net/tracker/?func=detail&aid=2855978&group_id=36855&atid=440764 heart hypertrophy]'', ''[https://sourceforge.net/tracker/?func=detail&aid=2855911&group_id=36855&atid=440764 septum morphogenesis]'', ''[https://sourceforge.net/tracker/?func=detail&aid=2855530&group_id=36855&atid=440764 chamber development]'', ''[https://sourceforge.net/tracker/?func=detail&aid=2855529&group_id=36855&atid=440764 heart valves]''
|
|-valign="top"
|'''3:45pm'''
|Coffee break
|
|-valign="top"
|'''4pm'''
|Cardiac conduction<br/>*  development of the electrical signaling systems of the heart<br/>* SF - ''[https://sourceforge.net/tracker/?func=detail&aid=2531687&group_id=36855&atid=440764 cardiac conduction]''
|
|-valign="top"
|'''5pm'''
|Close
|
|}


== Working group ==
== Working group ==

Revision as of 08:44, 26 May 2011

Venue and date

UCL, Possibly Thursday 10th and Friday 11th (1/2 day) November 2011 (to tie in with GOC meeting)

Draft Programme

9:15am Coffee and breakfast pastries
9:30am Welcome and introduction Varsha
9:35am Introduction to GO David
9:45am Check terms are applicable across Bilateria
* heart
* blood
* vessels
* SF - blood circulation
Susan
10:15am Cardiac precursor tissues and cells
* Development of primary and secondary heart fields
* cardiac muscle cell specification/differentiation/development
* cardiac endothelial cell specification/differentiation/development
* SF - symmetry/asymmetry,heart field, heart cone, precursor cell differentiation, endocardium,
11am Coffee break
11:45am Cardiac cell migration, Heart morphogenesis
* morphogenic and migratory changes to those cell populations as they move towards formation of the heart tube
* L/R patterning
* neural crest contribution to the heart
* SF - cell migration, heart tube, heart looping and jogging
12:30pm Lunch at Ask on Grafton Way. Menu
2pm Continue with Cardiac cell migration, Heart morphogenesis
2:45pm Heart structure formation
* heart chamber, septum, trabeculae, valves
* SF - heart hypertrophy, septum morphogenesis, chamber development, heart valves
3:45pm Coffee break
4pm Cardiac conduction
* development of the electrical signaling systems of the heart
* SF - cardiac conduction
5pm Close

Working group

GO curators and editors: David, Ruth, Doug, Tanya, Becky, Paola, Stan, Susan

Expert scientists:

  • Agreed to attend:
    • Prof Peter Scambler p.scambler@ich.ucl.ac.uk (if needed)
    • Prof Shoumo Bhattacharya shoumo@me.com
    • Prof Paul Riley p.riley@ich.ucl.ac.uk
  • Waiting for reply:
    • Ross A Breckenridge r.breckenridge@ucl.ac.uk
  • Possible other experts to contact:
    • Prof Andrew Tinker rmhaant@ucl.ac.uk Varsha has discussed the ontology with him before
    • Dr Pier Lambiase pier.lambiase@uclh.nhs.uk Consultant Cardiologist
    • Prof Robert Anderson (r.anderson@ich.ucl.ac.uk) Publishes in this area
    • Bernard de Bono (virtual physiology)
    • Adrian Wolff (Kidney development ontology)

Minutes GOC Satallite meeting 5:30 - 6:30 Thursday 19th May 2011 LA

  • David, Ruth, Doug, Tanya, Becky, Paola, Stan
  • Currently only 2 GO terms in this ontology:
    • Cardiac conduction
    • Atrioventricular node impulse conduction delay
  • Missing links/terms
    • regulation of cardiac muscle contraction
    • regulation of heart rate
    • strength of heart contraction
    • blood pressure
    • sensing
    • systemic signaling
    • hormone signaling (note forth coming development of this domain)
    • action potential
    • long synaptic potential
    • synaptic plasticity
    • regulation of membrane potential
  • Ontology for development of the cardiac conduction system pretty much sorted, maybe a few additional cell types to add, but this shouldn't be the scope of this workshop.
  • Workshop for ontology for neurological terms on 7th September 2011
    • Ideally Paola to attend this meeting (note Paolo has a neurological background)

Action items

  • All:
    • Work towards identifying scope of workshop, set by mid July
    • Set up table for annotation guide - what genes to annotate to these new GO terms, perhaps capture experimental information here. Eg how to interpret changes in P or QRS intervals associated with specific genes.
    • Add figures to wiki to illustrate cardiac conduction processes
    • Add useful reviews/papers to wiki
  • Ruth:
    • Contact experts above (max 5 experts)
    • Book rooms
    • Ask experts to review blood pressure ontology
    • Ask Varsha for her draft ontology
  • Doug:
    • Look at differences and similarities between zebrafish and mammalian cardiac conduction processes
  • David and Tanya
    • Set up overview of ontology
  • Stan
    • Review hormone literature/ontology
  • Paolo
    • Pacemaker
  • Susan
    • Look at differences and similarities between Drosophila and mammalian cardiac conduction processes
  • Becky
    • Look at key signaling pathways that regulate heart rate & cardiac conduction.

Useful papers

The emerging genetic landscape underlying cardiac conduction system function PMID: 21538814 [1]

Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel (zebrafish) PMID: 20657579 [2]

Useful figures

PMID: 21538814

Relevant Source Forge Requests

Cardiac conduction [[3]]

Regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion [[4]]

Cardiac muscle contraction [[5]]

Regulation of ventricular cardiac muscle repolarization [[6]]

Relaxation of cardiac muscle [[7]]

Heart contraction terms [[8]]

Ontology discussion documents

Varsha's original ontology suggestions File:HeartConductionDraftOntology2009.pdf Varsha's notes on discussion of ontology with Andy Tinker File:HeartConductionOntologyDiscussion.pdf