Cardiac conduction: Difference between revisions
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== Draft Programme == | == Draft Programme == | ||
Thursday 10th November 2011 | |||
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|'''9:30am''' | |'''9:30am''' | ||
| Welcome and introduction | | Welcome and introduction | ||
| | |Ruth | ||
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|'''9:35am''' | |'''9:35am''' | ||
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|David | |David | ||
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|'''9: | |'''9:55am''' | ||
|Check terms are applicable across Bilateria | |Check terms are applicable across Bilateria | ||
|Susan | |Susan | ||
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|Overview of current cardiac conduction description in GO, start to work on ontology | |Overview of current cardiac conduction description in GO, start to work on ontology | ||
|David | |David | ||
|'''11am''' | |'''11am''' | ||
|Coffee break | |Coffee break | ||
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|'''5pm''' | |'''5pm''' | ||
|Close | |||
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Friday 11th November 2011 | |||
{| border="1" cellpadding="2" width=1000px | |||
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|width="5%"|'''9:15am''' | |||
|width="90%"|Coffee and breakfast pastries | |||
|width="5%"| | |||
|-valign="top" | |||
|'''9:30am''' | |||
| Welcome back and questions | |||
|Ruth | |||
|-valign="top" | |||
|'''9:35am''' | |||
|Complete annotation documentation, decide how specific genes known to be involved in various cardiac conduction processes will be annotated using the new ontology | |||
| | |||
|-valign="top" | |||
|'''11am''' | |||
|Coffee break | |||
| | |||
|-valign="top" | |||
|'''11:30am''' | |||
| | |||
|-valign="top" | |||
|'''1pm''' | |||
|Close | |Close | ||
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Revision as of 08:55, 26 May 2011
Venue and date
UCL, Possibly Thursday 10th and Friday 11th (1/2 day) November 2011 (to tie in with GOC meeting)
Draft Programme
Thursday 10th November 2011
9:15am | Coffee and breakfast pastries | ||||
9:30am | Welcome and introduction | Ruth | |||
9:35am | Introduction to GO | David | |||
9:55am | Check terms are applicable across Bilateria | Susan | |||
10:00am | Overview of current cardiac conduction description in GO, start to work on ontology | David | 11am | Coffee break | |
11:30am | |||||
12:30pm | Lunch at Ask on Grafton Way. Menu | ||||
2pm | Continue with Ontology | ||||
2:45pm | |||||
3:45pm | Coffee break | ||||
4pm | |||||
5pm | Close |
Friday 11th November 2011
9:15am | Coffee and breakfast pastries | |
9:30am | Welcome back and questions | Ruth |
9:35am | Complete annotation documentation, decide how specific genes known to be involved in various cardiac conduction processes will be annotated using the new ontology | |
11am | Coffee break | |
11:30am | ||
1pm | Close |
Working group
GO curators and editors: David, Ruth, Doug, Tanya, Becky, Paola, Stan, Susan
Expert scientists:
- Agreed to attend:
- Prof Peter Scambler p.scambler@ich.ucl.ac.uk (if needed)
- Prof Shoumo Bhattacharya shoumo@me.com
- Prof Paul Riley p.riley@ich.ucl.ac.uk
- Waiting for reply:
- Ross A Breckenridge r.breckenridge@ucl.ac.uk
- Possible other experts to contact:
- Prof Andrew Tinker rmhaant@ucl.ac.uk Varsha has discussed the ontology with him before
- Dr Pier Lambiase pier.lambiase@uclh.nhs.uk Consultant Cardiologist
- Prof Robert Anderson (r.anderson@ich.ucl.ac.uk) Publishes in this area
- Bernard de Bono (virtual physiology)
- Adrian Wolff (Kidney development ontology)
Minutes GOC Satallite meeting 5:30 - 6:30 Thursday 19th May 2011 LA
- David, Ruth, Doug, Tanya, Becky, Paola, Stan
- Currently only 2 GO terms in this ontology:
- Cardiac conduction
- Atrioventricular node impulse conduction delay
- Missing links/terms
- regulation of cardiac muscle contraction
- regulation of heart rate
- strength of heart contraction
- blood pressure
- sensing
- systemic signaling
- hormone signaling (note forth coming development of this domain)
- action potential
- long synaptic potential
- synaptic plasticity
- regulation of membrane potential
- Ontology for development of the cardiac conduction system pretty much sorted, maybe a few additional cell types to add, but this shouldn't be the scope of this workshop.
- Workshop for ontology for neurological terms on 7th September 2011
- Ideally Paola to attend this meeting (note Paolo has a neurological background)
Action items
- All:
- Work towards identifying scope of workshop, set by mid July
- Set up table for annotation guide - what genes to annotate to these new GO terms, perhaps capture experimental information here. Eg how to interpret changes in P or QRS intervals associated with specific genes.
- Add figures to wiki to illustrate cardiac conduction processes
- Add useful reviews/papers to wiki
- Ruth:
- Contact experts above (max 5 experts)
- Book rooms
- Ask experts to review blood pressure ontology
- Ask Varsha for her draft ontology
- Doug:
- Look at differences and similarities between zebrafish and mammalian cardiac conduction processes
- David and Tanya
- Set up overview of ontology
- Stan
- Review hormone literature/ontology
- Paolo
- Pacemaker
- Susan
- Look at differences and similarities between Drosophila and mammalian cardiac conduction processes
- Becky
- Look at key signaling pathways that regulate heart rate & cardiac conduction.
Useful papers
The emerging genetic landscape underlying cardiac conduction system function PMID: 21538814 [1]
Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel (zebrafish) PMID: 20657579 [2]
Useful figures
Relevant Source Forge Requests
Cardiac conduction [[3]]
Regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion [[4]]
Cardiac muscle contraction [[5]]
Regulation of ventricular cardiac muscle repolarization [[6]]
Relaxation of cardiac muscle [[7]]
Heart contraction terms [[8]]
Ontology discussion documents
Varsha's original ontology suggestions File:HeartConductionDraftOntology2009.pdf Varsha's notes on discussion of ontology with Andy Tinker File:HeartConductionOntologyDiscussion.pdf