Cardiac conduction

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Venue and date

UCL, Possibly Wednesday 9th - Thursday (1/2 day) 10th Nov 2011

Working group

GO curators and editors: David, Ruth, Doug, Tanya, Becky, Paola, Stan, Susan

Expert scientists:

  • Agreed to attend:
    • Prof Peter Scambler <p.scambler@ich.ucl.ac.uk> (if needed)
    • Prof Shoumo Bhattacharya <shoumo@me.com>
    • Prof Paul Riley <p.riley@ich.ucl.ac.uk>
  • Waiting for reply:
    • Ross A Breckenridge <r.breckenridge@ucl.ac.uk>
  • To contact:
    • Prof Andrew Tinker <rmhaant@ucl.ac.uk>
    • Dr Pier Lambiase <pier.lambiase@uclh.nhs.uk> Consultant Cardiologist
    • Prof Robert Anderson (r.anderson@ich.ucl.ac.uk) Based on his publication record he would be a a good choice
    • Bernard de Bono (virtual physiology)

Minutes GOC Satallite meeting 5:30 - 6:30 Thursday 19th May 2011 LA

  1. David, Ruth, Doug, Tanya, Becky, Paola, Stan
  1. Currently only 2 GO terms in this ontology:
    • Cardiac conduction
    • Atrioventricular node impulse conduction delay
  1. Missing links/terms
    • regulation of cardiac muscle contraction
    • regulation of heart rate
    • strength of heart contraction
    • blood pressure
    • sensing
    • systemic signaling
    • hormone signaling (note forth coming development of this domain)
  1. Ontology for development of the cardiac conduction system pretty much sorted, maybe a few additional cell types to add, but this shouldn't be the scope of this workshop.
  1. Workshop for ontology for neurological terms on 7th September 2011
    • Ideally Paola to attend this meeting (note Paolo has a neurological background)

Action items

  1. All:
    • Work towards identifying scope of workshop, set by mid July
    • Set up table for annotation guide - what genes to annotate to these new GO terms, perhaps capture experimental information here. Eg how to interpret changes in P or QRS intervals associated with specific genes.
    • Add figures to wiki to illustrate cardiac conduction processes
    • Add useful reviews/papers to wiki
  1. Ruth:
    • Contact experts above (max 5 experts)
    • Book rooms
    • Ask experts to review blood pressure ontology
    • Ask Varsha for her draft ontology
  1. Doug:
    • Look at differences and similarities between zebrafish and mammalian cardiac conduction processes
  1. David and Tanya
    • Review how to tie cardiac conduction processes into signaling