Cardiac conduction
Venue and date
UCL, Possibly Wednesday 9th - Thursday (1/2 day) 10th Nov 2011 (to tie in with Hinxton Genomics meeting and GOC meeting)
Working group
GO curators and editors: David, Ruth, Doug, Tanya, Becky, Paola, Stan, Susan
Expert scientists:
- Agreed to attend:
- Prof Peter Scambler <p.scambler@ich.ucl.ac.uk> (if needed)
- Prof Shoumo Bhattacharya <shoumo@me.com>
- Prof Paul Riley <p.riley@ich.ucl.ac.uk>
- Waiting for reply:
- Ross A Breckenridge <r.breckenridge@ucl.ac.uk>
- To contact:
- Prof Andrew Tinker <rmhaant@ucl.ac.uk>
- Dr Pier Lambiase <pier.lambiase@uclh.nhs.uk> Consultant Cardiologist
- Prof Robert Anderson (r.anderson@ich.ucl.ac.uk) Based on his publication record he would be a a good choice
- Bernard de Bono (virtual physiology)
Minutes GOC Satallite meeting 5:30 - 6:30 Thursday 19th May 2011 LA
- David, Ruth, Doug, Tanya, Becky, Paola, Stan
- Currently only 2 GO terms in this ontology:
- Cardiac conduction
- Atrioventricular node impulse conduction delay
- Missing links/terms
- regulation of cardiac muscle contraction
- regulation of heart rate
- strength of heart contraction
- blood pressure
- sensing
- systemic signaling
- hormone signaling (note forth coming development of this domain)
- action potential
- long synaptic potential
- synaptic plasticity
- regulation of membrane potential
- Ontology for development of the cardiac conduction system pretty much sorted, maybe a few additional cell types to add, but this shouldn't be the scope of this workshop.
- Workshop for ontology for neurological terms on 7th September 2011
- Ideally Paola to attend this meeting (note Paolo has a neurological background)
Action items
- All:
- Work towards identifying scope of workshop, set by mid July
- Set up overview of ontology
- Set up table for annotation guide - what genes to annotate to these new GO terms, perhaps capture experimental information here. Eg how to interpret changes in P or QRS intervals associated with specific genes.
- Add figures to wiki to illustrate cardiac conduction processes
- Add useful reviews/papers to wiki
- Ruth:
- Contact experts above (max 5 experts)
- Book rooms
- Ask experts to review blood pressure ontology
- Ask Varsha for her draft ontology
- Doug:
- Look at differences and similarities between zebrafish and mammalian cardiac conduction processes
- David and Tanya
- ?
- Stan
- Review hormone literature/ontology
- Paolo
- Pacemaker
- Susan
- Look at differences and similarities between Drosophila and mammalian cardiac conduction processes
- Becky
- Look at key signaling pathways that regulate heart rate & cardiac conduction.
Useful papers
The emerging genetic landscape underlying cardiac conduction system function PMID: 21538814 [1]
Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel (zebrafish) PMID: 20657579 [2]
Useful figures
Relevant Source Forge Requests
Cardiac conduction [[3]]
Regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion [[4]]
Cardiac muscle contraction [[5]]
Regulation of ventricular cardiac muscle repolarization [[6]]
Relaxation of cardiac muscle [[7]]
Heart contraction terms [[8]]