Cardiac conduction

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Venue and date

UCL, Possibly Thursday 10th and Friday 11th (1/2 day) November 2011 (to tie in with GOC meeting)

Draft Programme

Thursday 10th November 2011

9:15am Coffee and breakfast pastries
9:30am Welcome and introduction Ruth
9:35am Introduction to GO David
9:55am Check terms are applicable across Bilateria Susan
10:00am Overview of current cardiac conduction description in GO, start to work on ontology David
11am Coffee break
11:30am
12:30pm Lunch at Ask on Grafton Way. Menu
2pm Continue with Ontology
2:45pm
3:45pm Coffee break
4pm
5pm Close


Friday 11th November 2011

9:15am Coffee and breakfast pastries
9:30am Welcome back and questions Ruth
9:35am Complete annotation documentation, decide how specific genes known to be involved in various cardiac conduction processes will be annotated using the new ontology
11am Coffee break
11:30am
1pm Close

Working group

GO curators and editors: David, Ruth, Doug, Tanya, Becky, Paola, Stan, Susan

Expert scientists:

  • Agreed to attend:
    • Prof Peter Scambler p.scambler@ich.ucl.ac.uk (if needed)
    • Prof Shoumo Bhattacharya shoumo@me.com
    • Prof Paul Riley p.riley@ich.ucl.ac.uk
  • Waiting for reply:
    • Ross A Breckenridge r.breckenridge@ucl.ac.uk
  • Possible other experts to contact:
    • Prof Andrew Tinker rmhaant@ucl.ac.uk Varsha has discussed the ontology with him before
    • Dr Pier Lambiase pier.lambiase@uclh.nhs.uk Consultant Cardiologist
    • Prof Robert Anderson (r.anderson@ich.ucl.ac.uk) Publishes in this area
    • Bernard de Bono (virtual physiology)
    • Adrian Wolff (Kidney development ontology)

Minutes GOC Satallite meeting 5:30 - 6:30 Thursday 19th May 2011 LA

  • David, Ruth, Doug, Tanya, Becky, Paola, Stan
  • Currently only 2 GO terms in this ontology:
    • Cardiac conduction
    • Atrioventricular node impulse conduction delay
  • Missing links/terms
    • regulation of cardiac muscle contraction
    • regulation of heart rate
    • strength of heart contraction
    • blood pressure
    • sensing
    • systemic signaling
    • hormone signaling (note forth coming development of this domain)
    • action potential
    • long synaptic potential
    • synaptic plasticity
    • regulation of membrane potential
  • Ontology for development of the cardiac conduction system pretty much sorted, maybe a few additional cell types to add, but this shouldn't be the scope of this workshop.
  • Workshop for ontology for neurological terms on 7th September 2011
    • Ideally Paola to attend this meeting (note Paolo has a neurological background)

Action items

  • All:
    • Work towards identifying scope of workshop, set by mid July
    • Set up table for annotation guide - what genes to annotate to these new GO terms, perhaps capture experimental information here. Eg how to interpret changes in P or QRS intervals associated with specific genes.
    • Add figures to wiki to illustrate cardiac conduction processes
    • Add useful reviews/papers to wiki
  • Ruth:
    • Contact experts above (max 5 experts)
    • Book rooms
    • Ask experts to review blood pressure ontology
    • Ask Varsha for her draft ontology
  • Doug:
    • Look at differences and similarities between zebrafish and mammalian cardiac conduction processes
  • David and Tanya
    • Set up overview of ontology
  • Stan
    • Review hormone literature/ontology
  • Paolo
    • Pacemaker
  • Susan
    • Look at differences and similarities between Drosophila and mammalian cardiac conduction processes
  • Becky
    • Look at key signaling pathways that regulate heart rate & cardiac conduction.

Useful papers

The emerging genetic landscape underlying cardiac conduction system function PMID: 21538814 [1]

Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel (zebrafish) PMID: 20657579 [2]

Useful figures

PMID: 21538814

Relevant Source Forge Requests

Cardiac conduction [[3]]

Regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion [[4]]

Cardiac muscle contraction [[5]]

Regulation of ventricular cardiac muscle repolarization [[6]]

Relaxation of cardiac muscle [[7]]

Heart contraction terms [[8]]

Ontology discussion documents

Varsha's original ontology suggestions File:HeartConductionDraftOntology2009.pdf Varsha's notes on discussion of ontology with Andy Tinker File:HeartConductionOntologyDiscussion.pdf