Cell Cycle
Summary
The cell cycle terms in GO haven't been touched for a while. There's a number of problems with the current arrangement since the cell cycle is largely based on timing. Along with cell cycle experts, we need to find a better way to model the cell cycle in GO.
Personnel
GO
- Val
- GOEds
- Mary Dolan (MGI)?
External experts
- Prof. Martin Kuiper & group (Cell cycle ontology)
Key Issues
Viruses and the host cell cycle
Currently two separate cell cycle grouping terms in the viral node. Should they be merged or related? (once sorted out what processes are part of the cell cycle, and what processes regulate the cell cycle):
- modification by virus of host cell cycle regulation ; GO:0019055
- modulation by virus of host cell cycle ; GO:0060153
SF items
- cell cycle vs regulation of cell cycle
- endoreplication
- premeiotic DNA replication
- meiosis and mitosis cell cycle terms
- G0 phase
- involved_in versus during
- pre-replicative complex assembly
- mitotic spindle elongation
- cell cycle arrest in response to nitrogen starvation
- missing relationship for chromosome segregation?
Resources
Cell Cycle Ontology
- The CCO is a metaontology, which pulls in cell cycle terms from other ontologies (GO).
- PMID 19480664
- https://sourceforge.net/projects/cellcycleonto/
- For browsing the CCO: http://bioportal.bioontology.org/ontologies/1507