Cell Cycle
Summary
The cell cycle terms in GO haven't been touched for a while. There's a number of problems with the current arrangement since the cell cycle is largely based on timing. Along with cell cycle experts, we need to find a better way to model the cell cycle in GO.
Personnel
GO
- Val
- GOEds
- Mary Dolan (MGI)?
External experts
- ?
Key Issues
Summary from Val:
I had a read through most of the SF items and this is a general flavour of the problems. Problems include:
- General inconsistencies: [1] identifies some inconsistencies under cell cycle, and raises the questions
- Where does the cell cycle begin and end what do we mean by cell cycle as a process? should it exist, or should we only have a process "regulation of cell cycle" I think this implies that maybe we should separate "regulation of cell cycle" to come degree from the physical event like DNA replication, chromosome segregation, but I am not sure....[2]
- Problems linking events to timing, because events occur in different phases in different organisms
[https://sourceforge.net/tracker/?func=detail&aid=3371387&group_id=36855&atid=440764 ]
- A lot of issues which arise because we don't have a clear idea where sub processes begin and end. So for instance is spindle elongation part of chromosome segregation ?
[https://sourceforge.net/tracker/?func=detail&aid=3280845&group_id=36855&atid=440764 ]e.g. Chromosome segregation occurs in two phases: chromosomes move towards spindle poles during anaphase A, and spindle poles separate from each other during anaphase B.(PMID: 11309422). But the definition of chromosome segregation in GO ends when the chromosomes reach the spindle poles, suggesting that spindle elongation comes after:
Viruses and the host cell cycle
Currently two separate cell cycle grouping terms in the viral node. Should they be merged or related? (once sorted out what processes are part of the cell cycle, and what processes regulate the cell cycle):
- modification by virus of host cell cycle regulation ; GO:0019055
- modulation by virus of host cell cycle ; GO:0060153
SF items
- cell cycle vs regulation of cell cycle
- endoreplication
- premeiotic DNA replication
- meiosis and mitosis cell cycle terms
- G0 phase
- involved_in versus during
- pre-replicative complex assembly
- mitotic spindle elongation
- cell cycle arrest in response to nitrogen starvation
- missing relationship for chromosome segregation?
Resources
Cell Cycle Ontology
- The CCO is a metaontology, which pulls in cell cycle terms from other ontologies (GO).
- PMID 19480664
- https://sourceforge.net/projects/cellcycleonto/
- For browsing the CCO: http://bioportal.bioontology.org/ontologies/1507
Papers
Cell Cycle Content Meeting (EBI, Hinxton, UK)
Suggested dates are Feb. 28th and March 1st 2013.
Link to meeting page: http://wiki.geneontology.org/index.php/Cell_Cycle_Content_Meeting_Feb_2013