Chaperones

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Intro

As part of the transporter activity overhaul it has become apparent that the chaperone terms need some work. We are planning to do this straight after the transporter activity implementation goes live.

Background

The most recent email thread (March 2007):

Val 26 Mar 2007 18:08:20

Summary, as I understand it: (CCing Midori too...Midori do you remember any lurking SF entries or action items relating to this?)

'metallochaperone' and 'protein folding chaperone' will be direct children of 'molecular function'

ONLY 'protein transport chaperone' will be a child of transporter activity

NONE would have any term or relationship under 'transmembrane transporter activity'

(Need to explain a bit about why this is necessary)

The only SF entry I can see is mine here [1233407] but I'm sure this has been discussed in other SF items and possibly even at annotation camp. Jen can you find any other background for this? it would give it more weight.....

If you two could comment, then Jen perhaps this could go to the transport interest group, Maria, Rama, and David for further comments?

This is my first attempt

I propose we resurrect this and the def (or something very similar)

chaperone activity

OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function.
This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes. To update annotations, consider the molecular function term 'unfolded protein binding ; GO:0051082' and the biological process term 'protein folding ; GO:0006457' and its children.

rename as
protein folding chaperone activity
synonym chaperone activity
Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, by binding unfolded proteins to stabilize and prevent aggregation. Chaperones do not form a part of the assembled structures when they are performing their normal biological function.

protein transport chaperone

A protein which recognises and binds a protein substrate and transports it within the cell via a protein trafficking mechanism.???

a child would be protein carrier activity and would have a def consistent with the eventual def for protein transport chaperone

a child of this would be
GO:0008262 : importin-alpha export receptor activity (gene product)
renamed to:
nucleocytoplasmic protein carrier activity
This would deal with SF [1455372]

metallochaperone activity

Assists in the delivery of metal ions to target proteins (need to extend this def)