Directly positively regulates: Difference between revisions
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== Overview == | == Overview == | ||
The 'directly positively regulates' relation is used to relate two GO Molecular Functions whenever two Molecular Functions succeed one another directly, and the first | The 'directly positively regulates' relation is used to relate two GO Molecular Functions whenever two Molecular Functions succeed one another directly, and the first regulates the activity of the second via a direct physical interactions. The 'directly positively regulates' relation is used to describe a relation, for example, between a ligand and the receptor that it activates. | ||
=== Definition === | === Definition === | ||
Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2. | Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2. | ||
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== Relations Ontology == | == Relations Ontology == | ||
[http://www.ontobee.org/ontology/RO?iri=http | [http://www.ontobee.org/ontology/RO?iri=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FRO_0002629 directly positively regulates] | ||
== Review Status == | == Review Status == | ||
Last reviewed: | Last reviewed: August 8, 2019 | ||
[http://wiki.geneontology.org/index.php/Annotation_Relations Back to: Annotation Relations] | [http://wiki.geneontology.org/index.php/Annotation_Relations Back to: Annotation Relations] | ||
Revision as of 10:05, 8 August 2019
Overview
The 'directly positively regulates' relation is used to relate two GO Molecular Functions whenever two Molecular Functions succeed one another directly, and the first regulates the activity of the second via a direct physical interactions. The 'directly positively regulates' relation is used to describe a relation, for example, between a ligand and the receptor that it activates.
Definition
Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2.
Child Terms
Examples of Usage
- In GO-CAM models, the 'directly positively regulates' relation is used for associations between two Molecular Functions.
- In canonical Wnt signaling, a Wnt ligand 'directly positively regulates' the activity of a Frizzled receptor.
- Examplar: http://noctua.berkeleybop.org/editor/graph/gomodel:56d1143000003025
Quality Control Checks
Relations Ontology
Review Status
Last reviewed: August 8, 2019