Diuresis and Natiuresis call, Thursday 24th March 2011: Difference between revisions

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The balance between the water and sodium levels of urine depends on the animal and its habitat (what it ingests and what it loses through non-renal routes). Thus a zebrafish living in fresh water excretes a water-rich urine whereas a shark in seawater excretes very little water in the urine.  
The balance between the water and sodium levels of urine depends on the animal and its habitat (what it ingests and what it loses through non-renal routes). Thus a zebrafish living in fresh water excretes a water-rich urine whereas a shark in seawater excretes very little water in the urine.  


Randy (Sanjay Jain, Helen Skaer and Jamie Davis agree):
Randy (Sanjay Jain, Helen Skaer and Jamie Davies agree):
*absorption  (usually called reabsorption, since it happens after filtration of the fluid into the nephron at the glomerulus) always refers to transport out of the nephron back into the general circulation.
*absorption  (usually called reabsorption, since it happens after filtration of the fluid into the nephron at the glomerulus) always refers to transport out of the nephron back into the general circulation.
*secretion always refers to transport (whether passive or active) into the tubular fluid of any nephron segment from the blood/interstitium.
*secretion always refers to transport (whether passive or active) into the tubular fluid of any nephron segment from the blood/interstitium.

Revision as of 11:37, 23 March 2011

BACKGROUND TO DIURESIS AND NATRIURESIS TERMS

The following SF item requests a rearrangement of the existing diuresis and natriuresis GO terms: https://sourceforge.net/tracker/index.php?func=detail&aid=3202051&group_id=36855&atid=440764


Current definitions and Placements

  • diuresis ; GO:0030146. The process of renal water excretion.
  • natriuresis ; GO:0030147. The process of renal sodium excretion.


Their current placement in the graph:


The current parents of diuresis:


The current parents of natriuresis:


Problems with the existing terms

1/ URINE VERSUS RENAL WATER

The first problem is the request to update the definition of the terms from 'renal water' to 'urine'.


2/ EXCRETION VERSUS REGULATION OF EXCRETION

The second issues is that diuresis represents an increase in flow of urine, and natriuresis represents an increase in sodium content of urine. The current diuresis and natriuresis terms have 'regulation' children that represent this.


Summary of email discussions so far

Based on the common-use of 'diuresis' and 'natriuresis', we probably want to change them to REGULATION terms.

  • diuresis = through (flow) (from dia) of urine; the word is usually used in the sense of increasing flow (eg diuretics) (Jamie Davies)
  • Diuresis = an increase in urine flow (i.e. increase in urine volume per unit time) (Adrian Woolf)
  • Natiuresis = an increase in amount of sodium appearing in the final urine per unit time. (Adrian Woolf)

The balance between the water and sodium levels of urine depends on the animal and its habitat (what it ingests and what it loses through non-renal routes). Thus a zebrafish living in fresh water excretes a water-rich urine whereas a shark in seawater excretes very little water in the urine.

Randy (Sanjay Jain, Helen Skaer and Jamie Davies agree):

  • absorption (usually called reabsorption, since it happens after filtration of the fluid into the nephron at the glomerulus) always refers to transport out of the nephron back into the general circulation.
  • secretion always refers to transport (whether passive or active) into the tubular fluid of any nephron segment from the blood/interstitium.
  • excretion is reserved for flow out of the kidney via the collecting ducts (so, towards the bladder, for ultimate excretion from the body).

NB: ultimate excretion from the body is covered by the GO process: micturition ; GO:0060073 (exact synonym: urination)

PROPOSAL

  excretion
  --[isa]urine excretion ; GO:NEW
  ----[R]regulation of urine excretion ; GO:NEW
  ------[isa]positive regulation of urine excretion (synonym: diuresis)
  ------[isa]negative regulation of urine excretion
  ----[partof]urine sodium excretion; GO:NEW
  ------[isa]positive regulation of urine sodium excretion (synonym: natriuresis)
  ------[isa]negative regulation of urine sodium excretion
  
  urine excretion ; GO:NEW
  def: The expulsion of urine from the kidneys. The process begins with urine leaving the kidneys (via the collecting ducts and flowing towards the bladder, in mammals) and ends with the ultimate excretion of urine from the body (urination).
  is_a: excretion
  is_a: renal system process
  is_a: regulation of body fluid levels
  part_of: renal water homeostasis ; GO:0003091 ??
  Since the filtration and absorption steps aren't involved in urine excretion, but REGULATE urine excretion, we could create terms:
  regulation of urine excretion by glomerular filtration
  regulation of urine excretion by renal absorption
  regulation of urine excretion by renal water absorption
  regulation of urine sodium excretion by renal sodium ion absorption
  Since we are altering the meaning of 'diuresis' and 'natriuresis', I would favour obsoleting:
  diuresis ; GO:0030146 
  natriuresis ; GO:0030147
  and adding in replacement suggestions to the new regulation terms.
  We need to look at the 'regulation of diuresis' and 'regulation of natriuresis' terms. These could probably be directly transferred to 'positive regulation of urine excretion' and 'positive regulation of renal sodium excretion'.



REMAINING QUESTIONS

  • How do we fit the urine terms with 'renal water homeostasis' terms?
  • Do we need a term for urine water excretion?
  • How should 'diuresis' and 'natriuresis' be related, in GO: siblings, or parent:child?
  • How to connect up 'pressure natriuresis ; GO:0003095': an increased urinary excretion of sodium AND water when arterial pressure increases.

MEETING DETAILS

Phone numbers to call:

  • Toll-free USA number 1-866-953-9688
  • Toll-free UK 0808 238 6001
  • Toll-free Switzerland 0800 562 830

Participant Pin: (801)-(561)


  • Yasmin has sent round an invitation to use Webex.


ATTENDEES

  • Dr. Yasmin Alam-Faruque (Renal GOA project curator; EBI)
  • Dr. Rebecca Foulger (GO editor; EBI)
  • Dr. David Hill ((GO Editor; MGI)
  • Prof. Randy Thomas (Renal Physiologist; IR4M CNRS UMR 8081, Equipe 5, Institut Gustave-Roussy, France)
  • Prof. Adrian Woolf (Professor of Paediatric Science, University of Manchester, UK)

MINUTES