Extensions2GO-CAM

Simple conversions

These are relations that are essentially identical in extensions and GO-CAM, and can be combined together into a "standard" GO-CAM activity.

• If the aspect is F (column A)
  • No more than one occurs_in(CC)
  • No more than one occurs_in(CL)
  • No more than one occurs_in(UBERON or EMAPA)
  • No more than one has_input/has_direct_input(geneID or ChEBI)
    • EXCEPTION: if term is "molecular function regulator activity" or descendant, can also add -directly-regulates->[MF of GP-B]
  • No more than one happens_during(BP)
  • No more than one part_of(BP)
  • No more than one activated_by(ChEBI)
  • No more than one inhibited_by(ChEBI)
• If the aspect is C
  • No more than one occurs_in(CC)
  • No more than one occurs_in(CL)
  • No more than one occurs_in(UBERON or EMAPA)
• If the aspect is P
  • No more than one occurs_in(CC)
  • No more than one occurs_in(CL)
  • No more than one occurs_in(UBERON or EMAPA)
  • No more than one has_input/has_direct_input(geneID or ChEBI)
  • No more than one part_of(BP)

has_regulation_target

NOTE CAN ONLY BE USED ON AN MF ANNOTATION; CARDINALITY MUST BE 0 OR 1

• GP-A [regulation of molecular function Z] has_regulation_target GP-B
  • term is GO:0065009 and descendants
  • can be expressed as [GP-A]<-enabled_by-[root MF]-regulates->[molecular function Z]-enabled_by->[GP-B]
  • The variations on this are all children of the term “regulation of molecular function” (GO:0065009). Variations are “positive regulation of MF Z”, which would be expressed with the positively_regulates relation instead; “negative regulation of MF Z”. **Note that MF Z should appear in the logical definition of the term “regulation of MF Z”, or in a triple with the regulates relation, so we can get the GO ID from that.
• GP-A [regulation of gene expression OR regulation of protein biosynthetic process Z] has_regulation_target GP-B
  • These can be modeled as GP-A<-enabled_by-[root MF]-part_of->[regulation of Z]-has_input->GP-B,-positively-regulates->[root MF]-enabled_by->GP-B
• GP-A [Regulation of receptor internalization (GO:0002092) OR regulation of protein catabolic process Z] has_regulation_target GP-B
  • These are GO:0002092 and descendants, or GO:0042176 and descendants
  • These can be modeled as GP-A<-enabled_by-[root MF]-part_of->[regulation of Z]-has_input->GP-B,-negatively-regulates->[root MF]-enabled_by->GP-B
• GP-A [regulation of protein metabolic process Z, not including cases above, or regulation of protein localization] has_regulation_target GP-B
• These are GO:0019538 and the descendants that are not also descendants of terms listed above, or GO:0032880 and descendants
  • These can be modeled as GP-A<-enabled_by-[root MF]-part_of->[regulation of Z]-has_input->GP-B,-negatively-regulates->[root MF]-enabled_by->GP-B