Folding and Unfolding

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The folding operation creates a new application ontology on the fly, with each extended annotation materializing a new GO term. An OWL reasoner is used to automatically construct the graph in this new ontology. Application of this method can be seen as a stopgap to allow continued use of existing tools – the resulting application ontology, whilst logically complete, may be unwieldy for querying and browsing.

The unfolding method takes annotations to existing highly specific GO terms, and replaces them with an annotation to a more basic GO term, with the equivalent additional information now expressed as extensions. Examples available for the relationships: Occurs_in Annotation_Extension_Relation:occurs_in