GO-CAM Conference Call - 2019-05-21

Call Information

• See GO's Google calendar for Zoom URL
• email Kimberly if you need access to the GO's Google calendar

Agenda

Annotation Imports

• Status update on MGI and WB annotation imports
  • Implemented imports of With/From
  • Re-visiting the rule for modeling BP 'regulation of MF' with has_regulation_target extension
  • Additional annotation extensions coming on board
• Track issues on github/gocamgen

Modeling Questions

• From Sabrina on go-annotation gitter:
  • "caspy2 binds directly to lipopolysaccharide, resulting in caspy2 oligomerization, which is critical for pyroptosis" ([https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076302 PMID:30076291})
  • I started a GOCAM model, but I am not sure it is correct
  • Summary figure from paper

• Related question on modeling activities that influence dimerization state of another protein
  • Role of heat shock proteins in initiating C. elegans IRE1-ER UPR
  • See: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423427/figure/F3/