GO slim overhaul (completed 2009)

From GO Wiki
Revision as of 08:43, 7 October 2009 by Jl242 (talk | contribs) (→‎Meetings)
Jump to navigation Jump to search

We plan to completely revise the generic GO slim, and in the process come up with some guidelines for developing slims. This project began in Sept 2009.

Personnel

Jane, Val

Notes

  • Ideally want three "generic" slims:
    • truly generic slim for all species (probably very high level indeed)
    • slim for multi-cellular organisms
    • slim for single-celled organisms
  • could also do eukaryotic vs. prokaryotic
  • Other considerations
    • Email with specific queries about terms included and omitted from current (as of June 2009 page creation, actual last update much earlier)
    • Mailing list thread with Val's criteria for term selection Amelia comment:Most of this might be automatable, the hardest part of automatation will be to identify "biologically relevent terms". may be necessary to look at "extermal sources of terms"
    • Can we avoid "other X" terms? They're confusing and hard to handle.
    • Try to make slims is_a complete

Tangentially related: Does anyone know of a web-based slimming tool which shows the number of gene products which are annotated, but not to any term in your slim, and the number which are not annotated to any GO term (i.e root node annotations)? (question from Val)

Linda suggested:

  1. slim for metagenomics
  2. Collecting purpose made slims

Meetings

Terms:

  1. cellular component assembly
  2. anatomical structure formation involved in morphogenesis
  3. cell adhesion (look at multicellular organism adhesion later)
    • look at "biological regulation" later
    • look at cell killing later (may be picked up if we include multicellular organismal process although this is a bit broad)
  4. protein complex assembly
  5. ribonucleoprotien complex assembly
  6. cell wall organization or biogenesis
  7. extracellular matrix organization
  8. membrane organization
  9. chromosome organization
  10. cytoskeletal organization
  11. mitosis
  12. cell adhesion
  13. aging
  14. signal transduction
  15. cell-cell signalling
  16. cell cycle
  17. cell death
  18. cell division
  19. growth
  20. cell proliferation

upto cellular process, cell growth (18 Sept)

(when we choose terms we should also consider IEA annotations as will give a better idea of how many gene products are likely to be to a term when "annotation complete")

  • Need to re-check how annotations are allocated to this slim when regulates is made non-transitive in map2slim (new in GO moose).

Issues to consider

  1. How will this slim be maintained to ensure it keeps in line with ontology rearrangements? Yearly revision? More frequent?
  2. What other slims should we maintain in the GO file: cellular v/s multicellular v/s multi-organism? Euk v/s prok?
  3. Mapping over different relations for map2slim - regulates?