Guide to GO Evidence Codes

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Revision as of 12:22, 21 November 2017 by Vanaukenk (talk | contribs) (Introduction)

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  • These guidelines are a guide to standard usage of the GO evidence codes.
  • Annotators may also find the evidence code decision tree useful in selecting the correct evidence code for an annotation.

Introduction

A GO annotation consists of a GO term associated with a specific reference that describes the work or analysis upon which the association between a specific GO term and gene product is based. Each annotation must also include an evidence code to indicate how the annotation to a particular term is supported. Although evidence codes do reflect the type of work or analysis described in the cited reference which supports the GO term to gene product association, they are not necessarily a classification of types of experiments/analyses. Note that these evidence codes are intended for use in conjunction with GO terms, and should not be considered in isolation from the terms. If a reference describes multiple methods that each provide evidence to make a GO annotation to a particular term, then multiple annotations with identical GO identifiers and reference identifiers but different evidence codes may be made.

Out of all the evidence codes available, only Inferred from Electronic Annotation (IEA) is not assigned by a curator. Manually-assigned evidence codes fall into four general categories: experimental, computational analysis, author statements, and curatorial statements.