Difference between revisions of "Guidelines for new Molecular Functions"

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* [[Curator Guide: Enzymes and Reactions]] (being reviewed)
 
* [[Curator Guide: Enzymes and Reactions]] (being reviewed)
 
* [[Notes on specific terms]] (being reviewed)
 
* [[Notes on specific terms]] (being reviewed)
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* Specificity of activities
  
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https://github.com/geneontology/go-ontology/issues/12257 @thomaspd commented that "An activity should not be named after a gene product, as a gene product could potentially have multiple molecular functions and not just the one it's named after. Also, protein phosphatase inhibitor means "directly [i.e. via direct physical interaction] inhibits some protein phosphatase activity", not "directly inhibits some protein named protein phosphatase 2A"-- properly speaking you don't inhibit a protein, you inhibit the activity of a protein."
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This was discussed briefly during the GO editors call: http://wiki.geneontology.org/index.php/Ontology_meeting_2016-01-28#TermGenie_review_queue
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While attendees were in general in agreement with the above, @tberardini pointed to cases in which we may want to keep the specificity, such as http://amigo.geneontology.org/amigo/term/GO:0018024#display-lineage-tab
  
  

Revision as of 06:32, 14 September 2018


https://github.com/geneontology/go-ontology/issues/12257 @thomaspd commented that "An activity should not be named after a gene product, as a gene product could potentially have multiple molecular functions and not just the one it's named after. Also, protein phosphatase inhibitor means "directly [i.e. via direct physical interaction] inhibits some protein phosphatase activity", not "directly inhibits some protein named protein phosphatase 2A"-- properly speaking you don't inhibit a protein, you inhibit the activity of a protein."

This was discussed briefly during the GO editors call: http://wiki.geneontology.org/index.php/Ontology_meeting_2016-01-28#TermGenie_review_queue

While attendees were in general in agreement with the above, @tberardini pointed to cases in which we may want to keep the specificity, such as http://amigo.geneontology.org/amigo/term/GO:0018024#display-lineage-tab