Implementation

13rd November, 2007

I have solved problems about almost all child terms of "response to drug" term. The changes are already in the lived file.

I have asked to ChEBI people (Kirill) if it would be possible to have these substance in ChEBI molecular structure ontology.We are waiting for that!

List of substances:

METHOTREXATE
CHEBI:44185 unclassified

CLOMIPRAMINE
tricyclic antidepressant
KEGG ID C06918
CAS 303-49-1

DESIPRAMINE
tricyclic antidepressant
KEGG ID C06943
CAS 50-47-5

IMIPRAMINE
tricyclic antidepressant
KEGG ID C07049
CAS 50-49-7

LOFEPRAMINE
tricyclic antidepressant
KEGG ID C07408
CAS 438-60-8

NORTRIPTYLINE
tricyclic antidepressant
KEGG ID C07274
CAS 72-69-5

PROTRIPTYLINE tricyclic antidepressant
KEGG ID C06824
CAS 50-48-6

TRIMIPRAMINE
tricyclic antidepressant
KEGG ID D00394
CAS 739-71-9

I have a thought: proposal for "drug transport" Try to follow ChEBI structure to move all child terms of "drug transport" out of this node.

Add a new term: GO:0014076 "chemical substance transport"
Move "chemical substance transport" as is_a child of "transport" general term
Add a new term: GO:0014077 "organic substance transport"
Move "organicl substance transport" as is_a child of "transport" general term
Move "antibiotic transport" as part_of "response to antibiotic"
Copy "antibiotic transport" as is_a of "chemical substance transport"
Move "bicyclomycin transport" as is_a "antibiotic transport"
Copy response to cycloheximide as is_a child of response to antibiotic
Move "cycloheximide transport" as is_a "antibiotic transport"
Move tetracyclin transport is_a GO:0014077 "organic substance transport"
Move organomercurial transport is_a GO:0014077 "organic substance transport"
Move nalidixic acid transport is_a child of antibiotic transport
Move alkane transport as is_a child of organic substance transport
Move carbonyl cyanide m-chlorophenylhydrazone transport as is_a child of organic substance transport
Move daunorubicin transport as is_a "antibiotic transport"

To be asked GO curator

Maybe I need to create a branch file in scratch directory named response_to_drug.obo
Proposal to obsolete drug export GO:0046618 has just 12 gene associations
Proposal to merge multidrug transport GO:0006855 .It has almost the same defintion of drug transport GO:00415893 but it has 318 gene associations.So we could merge it with "chemical substance transport"

To be asked ChEBI curator WAIT before doing that!!!!

This is my work on "response to drug" so far. picture of response to drug work