Inferred from Biological aspect of Ancestor (IBA)
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Overview
- IBA is a type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of an ancestral gene.
- The principles underlying phylogenetic-based annotation are described further in the Phylogenetic annotation overview, but briefly, this annotation pipeline relies on phylogenetic analyses to transfer annotations amongst related sequences based on common ancestry.
- Further information may be found in Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium by Gaudet et al., 2011.
Examples of IBA Usage
| DB Object ID | DB Object Symbol | GO ID | DB:Reference | Evidence Code | With (or) From |
|---|---|---|---|---|---|
| UniProtKB:A4IFJ9 | ATP6V1C2 | GO:0046961 | PAINT_REF:10137 | IBA | PANTHER:PTN000015490 |
Use of the With/From Field for IBA
- Use of the With/From field is mandatory for IBA annotations.
- Typically, a unique identifier for a Panther family tree node, e.g. PANTHER:PTN000280277, is used in the With/From field for IBA.
When IBA Should NOT be Used
Quality Control Checks
Evidence and Conclusion Ontology
ECO:0000318 biological aspect of ancestor evidence used in manual assertion
Links
Curator Guide to GO Evidence Codes
Gene Ontology website GO Evidence Codes list
Review Status
Last reviewed: February 28, 2018