View source for JAK-STAT signaling cascade ; GO:0007259

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For an image, see:

http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway

http://courses.washington.edu/conj/bess/jakstat/jakstat.htm

# Ligand-binding to the cell-surface receptor introduces a conformational change in the receptor, which brings the JAK proteins into close proximity with eachother. The close JAK proteins trans-phosphorylate eachother (may also autophosphorylate).
# Activated JAK proteins phosphorylate the receptor.
# STAT proteins are recruited to the phosphorylated receptor.
# JAK proteins phosphorylate the STAT proteins.
# Phosphorylated STAT proteins dimerize (hetero- or homo-) and translocate to the nucleus.
# STAT dimers enter the nucleus (through importin) and activate transcription of their target genes.



==JAK-STAT SIGNALING: Outstanding Questions==

where does JAK-STAT signaling begin?
# With the receptor, which activates JAK?
# With JAK activity (phosphorylating the receptor and downstream STAT proteins)?
E.g. is the receptor functioning in the cascade, or upstream of the cascade?


==TO_DO==

OBSOLETE 
  GO:0007261: JAK-induced STAT protein dimerization
 The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases.


==Papers==

*[[http://jcs.biologists.org/content/117/8/1281.full]]
*[[http://cshperspectives.cshlp.org/content/4/3/a011205.full PMID: 22383755]]




[[Category:Ontology]]