JAK-STAT signaling cascade ; GO:0007259: Difference between revisions

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(Created page with " JAK-STAT SIGNALING: Outstanding Questions. where does JAK-STAT signaling begin: 1. With the receptor, which activates JAK? 2. JAK activity (phosphorylating the receptor and dow...")
 
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JAK-STAT SIGNALING: Outstanding Questions.
JAK-STAT SIGNALING: Outstanding Questions.


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Key steps:
Key steps:


1. Ligand-binding to the cell-surface receptor introduces a conformational change in the receptor, which brings the JAK proteins into close proximity with eachother. The close JAK proteins trans-phosphorylate eachother (may also autophosphorylate).
# Ligand-binding to the cell-surface receptor introduces a conformational change in the receptor, which brings the JAK proteins into close proximity with eachother. The close JAK proteins trans-phosphorylate eachother (may also autophosphorylate).
2. Activated JAK proteins phosphorylate the receptor.
# Activated JAK proteins phosphorylate the receptor.
3. STAT proteins are recruited to the phosphorylated receptor.
# STAT proteins are recruited to the phosphorylated receptor.
4. JAK proteins phosphorylate the STAT proteins.
# JAK proteins phosphorylate the STAT proteins.
5. Phosphorylated STAT proteins dimerize (hetero- or homo-) and translocate to the nucleus.
# Phosphorylated STAT proteins dimerize (hetero- or homo-) and translocate to the nucleus.
6. STAT dimers enter the nucleus (through importin) and activate transcription of their target genes.
# STAT dimers enter the nucleus (through importin) and activate transcription of their target genes.




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==Papers==
==Papers==


http://jcs.biologists.org/content/117/8/1281.full
[http://jcs.biologists.org/content/117/8/1281.full]
http://cshperspectives.cshlp.org/content/4/3/a011205.full [PMID: 22383755]
[http://cshperspectives.cshlp.org/content/4/3/a011205.full [PMID: 22383755]]

Revision as of 09:05, 23 April 2013

JAK-STAT SIGNALING: Outstanding Questions.

where does JAK-STAT signaling begin: 1. With the receptor, which activates JAK? 2. JAK activity (phosphorylating the receptor and downstream STAT proteins)? E.g. is the receptor functioning in the cascade, or upstream of the cascade?


Key steps:

  1. Ligand-binding to the cell-surface receptor introduces a conformational change in the receptor, which brings the JAK proteins into close proximity with eachother. The close JAK proteins trans-phosphorylate eachother (may also autophosphorylate).
  2. Activated JAK proteins phosphorylate the receptor.
  3. STAT proteins are recruited to the phosphorylated receptor.
  4. JAK proteins phosphorylate the STAT proteins.
  5. Phosphorylated STAT proteins dimerize (hetero- or homo-) and translocate to the nucleus.
  6. STAT dimers enter the nucleus (through importin) and activate transcription of their target genes.


Papers

[1] [PMID: 22383755]

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