JAK-STAT signaling cascade ; GO:0007259: Difference between revisions
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Return to [[Main_Page|GOC Main Page]] | |||
For an image, see: | |||
http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway | |||
http://courses.washington.edu/conj/bess/jakstat/jakstat.htm | |||
# Ligand-binding to the cell-surface receptor introduces a conformational change in the receptor, which brings the JAK proteins into close proximity with eachother. The close JAK proteins trans-phosphorylate eachother (may also autophosphorylate). | # Ligand-binding to the cell-surface receptor introduces a conformational change in the receptor, which brings the JAK proteins into close proximity with eachother. The close JAK proteins trans-phosphorylate eachother (may also autophosphorylate). | ||
| Line 17: | Line 15: | ||
# STAT dimers enter the nucleus (through importin) and activate transcription of their target genes. | # STAT dimers enter the nucleus (through importin) and activate transcription of their target genes. | ||
==JAK-STAT SIGNALING: Outstanding Questions== | |||
where does JAK-STAT signaling begin? | |||
# With the receptor, which activates JAK? | |||
# With JAK activity (phosphorylating the receptor and downstream STAT proteins)? | |||
E.g. is the receptor functioning in the cascade, or upstream of the cascade? | |||
==TO_DO== | |||
OBSOLETE | |||
GO:0007261: JAK-induced STAT protein dimerization | |||
The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases. | |||
==Papers== | ==Papers== | ||
[http://jcs.biologists.org/content/117/8/1281.full] | *[[http://jcs.biologists.org/content/117/8/1281.full]] | ||
[http://cshperspectives.cshlp.org/content/4/3/a011205.full | *[[http://cshperspectives.cshlp.org/content/4/3/a011205.full PMID: 22383755]] | ||
[[Category:Ontology]] | |||
Latest revision as of 12:16, 16 December 2013
Return to GOC Main Page
For an image, see:
http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway
http://courses.washington.edu/conj/bess/jakstat/jakstat.htm
- Ligand-binding to the cell-surface receptor introduces a conformational change in the receptor, which brings the JAK proteins into close proximity with eachother. The close JAK proteins trans-phosphorylate eachother (may also autophosphorylate).
- Activated JAK proteins phosphorylate the receptor.
- STAT proteins are recruited to the phosphorylated receptor.
- JAK proteins phosphorylate the STAT proteins.
- Phosphorylated STAT proteins dimerize (hetero- or homo-) and translocate to the nucleus.
- STAT dimers enter the nucleus (through importin) and activate transcription of their target genes.
JAK-STAT SIGNALING: Outstanding Questions
where does JAK-STAT signaling begin?
- With the receptor, which activates JAK?
- With JAK activity (phosphorylating the receptor and downstream STAT proteins)?
E.g. is the receptor functioning in the cascade, or upstream of the cascade?
TO_DO
OBSOLETE
GO:0007261: JAK-induced STAT protein dimerization The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases.
Papers
- [[1]]
- [PMID: 22383755]