Kidney - Agenda for Kidney Development Ontology Content Meeting: Difference between revisions
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*'''Kidney Development Review Papers:''' | *'''Kidney Development Review Papers:''' | ||
** '''Mammalian reviews:''' | ** '''Mammalian reviews:''' | ||
*PMID 19906853 Advances in early kidney specification, development and patterning. Dressler M 2009. Talks about the essential roles of intrinsic nuclear factors and secreted signaling molecules in specifying renal epithelial stem cells and their self-renewal, in driving the complex dynamics of epithelial cell branching morphogenesis, and in nephron patterning. | ***PMID 19906853 Advances in early kidney specification, development and patterning. Dressler M 2009. Talks about the essential roles of intrinsic nuclear factors and secreted signaling molecules in specifying renal epithelial stem cells and their self-renewal, in driving the complex dynamics of epithelial cell branching morphogenesis, and in nephron patterning. | ||
*PMID 15554941 Transcriptional control of kidney development. Bouchard M. 2004. Talks about genes involved in nephric lineage specification (Pax2/Pax8/Lim1/Bmp4/Wt1/GDNF1/Eya1/Foxc1); metanephros development - UB positioning, induction, nephron induction, ureter branching, Stromal cell differentiation(Gdnf1/Eya1/Foxc1/2/Slit2/Robo2/Bmp4/Pax2/Hox11(HoxA11/C11/D11)/ Sall1/Wt1/Six1/Wnt4/Emx2/Gata3/BF2/Pod1/Pbx21. | ***PMID 15554941 Transcriptional control of kidney development. Bouchard M. 2004. Talks about genes involved in nephric lineage specification (Pax2/Pax8/Lim1/Bmp4/Wt1/GDNF1/Eya1/Foxc1); metanephros development - UB positioning, induction, nephron induction, ureter branching, Stromal cell differentiation(Gdnf1/Eya1/Foxc1/2/Slit2/Robo2/Bmp4/Pax2/Hox11(HoxA11/C11/D11)/ Sall1/Wt1/Six1/Wnt4/Emx2/Gata3/BF2/Pod1/Pbx21. | ||
*PMID 15380247 Recent genetic studies of mouse kidney development. Yu J, McMahon AP, Valerius MT. 2004. Has a nice diagram of the stages of nephron formation on p.551. Also lists genes investigated with particular molecular regulation of outgrowth of the uteric bud and regulation of tubulogenesis (Table 1; p552 - Gdf1, Six1, Slit2/Robo2, Wnt1, Fras1+Grip1, Pod1, Pbx1, Brn1, Psen1/2). | ***PMID 15380247 Recent genetic studies of mouse kidney development. Yu J, McMahon AP, Valerius MT. 2004. Has a nice diagram of the stages of nephron formation on p.551. Also lists genes investigated with particular molecular regulation of outgrowth of the uteric bud and regulation of tubulogenesis (Table 1; p552 - Gdf1, Six1, Slit2/Robo2, Wnt1, Fras1+Grip1, Pod1, Pbx1, Brn1, Psen1/2). | ||
*PMID 16760375 Role of transcriptional networks in coordinating early events during kidney development. Boyle S, de Caestecker Mark. 2006. Has nice diagrams of stages of early mammalian kidney development. Reviews transcription factors in mesenephric mesenchyme: Eya1/ Foxc1/2/ Hoxa/c/d11/ Pax2/ Pbx1/ Rar-alpha/beta2/ Sall1/ Six1/ Wt1. | ***PMID 16760375 Role of transcriptional networks in coordinating early events during kidney development. Boyle S, de Caestecker Mark. 2006. Has nice diagrams of stages of early mammalian kidney development. Reviews transcription factors in mesenephric mesenchyme: Eya1/ Foxc1/2/ Hoxa/c/d11/ Pax2/ Pbx1/ Rar-alpha/beta2/ Sall1/ Six1/ Wt1. | ||
*PMID 12094231 Coordinating early kidney development: lessons from gene targeting. Vainio S, Lin Y. 2002. Nice diagrams of kidney development. List of genes essential for early kidney development (Transcription Factors: Emx2/Eya1/Foxc1/Foxd1/Pax2/Rara,Rarb/Sall1/Wt1; Growth factors: Bmp4/Bmp7/Fgf7/Gdnf/Wnt4; Growth factors/receptors: Gfra1/Notch2/Ret; Proteoglycans and their biosynthetic enzymes: Hs2st/Gpc3). | ***PMID 12094231 Coordinating early kidney development: lessons from gene targeting. Vainio S, Lin Y. 2002. Nice diagrams of kidney development. List of genes essential for early kidney development (Transcription Factors: Emx2/Eya1/Foxc1/Foxd1/Pax2/Rara,Rarb/Sall1/Wt1; Growth factors: Bmp4/Bmp7/Fgf7/Gdnf/Wnt4; Growth factors/receptors: Gfra1/Notch2/Ret; Proteoglycans and their biosynthetic enzymes: Hs2st/Gpc3). | ||
* '''Other resources:''' | |||
**'''Kidney Development Websites:''' | |||
*** Mouse Anatomy Browser - '''[http://www.informatics.jax.org/searches/AMA.cgi?query=kidney]''' | |||
*** FMA human anatomy browser- '''[http://fme.biostr.washington.edu:8089/FME/index.html]''' | |||
*'''Kidney Development Websites:''' | *** GUDMAP browser - '''[http://www.gudmap.org/gudmap/pages/database_homepage.html]''' | ||
** Mouse Anatomy Browser - '''[http://www.informatics.jax.org/searches/AMA.cgi?query=kidney]''' | ****Metanephros '''[http://www.gudmap.org/Organ_Summaries/Metanephros/Metanephros.html]''' | ||
****renal vesicle '''[http://www.gudmap.org/Organ_Summaries/Metanephros/Metanephros_RV.html]''' | |||
** FMA human anatomy browser- '''[http://fme.biostr.washington.edu:8089/FME/index.html]''' | ** Kidney Development GO wiki [http://wiki.geneontology.org/index.php/Kidney_Development] | ||
** Loop of Henle GO Cocuration wiki [http://wiki.geneontology.org/index.php/Loop_of_Henle_Cocuration] | |||
** GUDMAP browser - '''[http://www.gudmap.org/gudmap/pages/database_homepage.html]''' | |||
* Kidney Development GO wiki [http://wiki.geneontology.org/index.php/Kidney_Development] | |||
* Loop of Henle GO Cocuration wiki [http://wiki.geneontology.org/index.php/Loop_of_Henle_Cocuration] | |||
== '''Notes''' == | == '''Notes''' == | ||
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* Keep an eye on definition compatability across species/taxa | * Keep an eye on definition compatability across species/taxa | ||
== Ontology Editing == | |||
Midori Harris and David Hill are working through terms added during the meeting and the SF items. The first changes from the meeting were committed to the live GO on February 8, 2010, in gene_ontology_write.obo revision 1.1010. | |||
The changes committed are summarized below and in the CVS log, and shown in detail in two diff files, [[initial_kdm_obodiff|one generated by the obodiff utility]] and [[initial_kdm_unix_diff|the other by the UNIX diff utility]]. | |||
<pre> | |||
2010-02-08 | |||
confirmed definition of 'kidney development' GO:0001822; adjusted parentage | |||
definition adjustments: | |||
GO:0001759 induction of an organ | |||
GO:0061005 cell differentiation involved in kidney development | |||
added synonyms: | |||
GO:0061004 pattern specification involved in kidney development | |||
new terms: | |||
GO:0072001 renal system development | |||
GO:0072002 Malpighian tubule development | |||
GO:0072003 kidney rudiment formation | |||
GO:0072004 kidney field specification | |||
GO:0072005 maintenance of kidney identity | |||
GO:0072006 nephron development | |||
GO:0072007 mesangial cell differentiation | |||
GO:0072008 glomerular mesangial cell differentiation | |||
GO:0072009 nephron epithelium development | |||
GO:0072010 glomerular epithelium development | |||
GO:0072011 glomerular endothelium development | |||
GO:0072012 glomerulus vasculature development | |||
GO:0072013 glomus development | |||
GO:0072014 proximal tubule development | |||
GO:0072015 glomerular visceral epithelial cell development | |||
GO:0072016 glomerular parietal epithelial cell development | |||
GO:0072017 distal tubule development | |||
GO:0072018 intermediate tubule development | |||
GO:0072019 proximal convoluted tubule development | |||
GO:0072020 proximal straight tubule development | |||
GO:0072021 ascending thin limb development | |||
GO:0072022 descending thin limb development | |||
GO:0072023 thick ascending limb development | |||
GO:0072024 macula densa development | |||
GO:0072025 distal convoluted tubule development | |||
GO:0072026 distal straight tubule development | |||
GO:0072027 connecting tubule development | |||
GO:0072028 nephron morphogenesis | |||
GO:0072029 long nephron development | |||
GO:0072030 short nephron development | |||
GO:0072031 S1 development | |||
GO:0072032 S2 development | |||
GO:0072033 renal vesicle formation | |||
GO:0072034 positive regulation of renal vesicle formation | |||
GO:0072035 pre-tubular aggregate formation | |||
GO:0072036 mesenchymal to epithelial transition involved in renal vesicle formation | |||
GO:0072037 mesenchymal stem cell differentiation involved in nephron morphogenesis | |||
GO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis | |||
GO:0072039 regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis | |||
GO:0072040 negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis | |||
GO:0072041 positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis | |||
GO:0072042 regulation of mesenchymal stem cell proliferation involved in nephron morphogenesis | |||
GO:0072043 regulation of pre-tubular aggregate formation by cell-cell signaling | |||
GO:0072044 collecting duct development | |||
GO:0072045 convergent extension involved in nephron morphogenesis | |||
GO:0072046 establishment of planar polarity involved in nephron morphogenesis | |||
GO:0072047 proximal/distal pattern formation involved in nephron development | |||
GO:0072048 renal system pattern specification | |||
GO:0072049 comma-shaped body morphogenesis | |||
GO:0072050 S-shaped body morphogenesis | |||
GO:0072051 juxtaglomerular apparatus development | |||
GO:0072052 juxtaglomerulus cell differentiation | |||
GO:0072053 renal inner medulla development | |||
GO:0072054 renal outer medulla development | |||
GO:0072055 renal cortex development | |||
GO:0072056 pyramids development | |||
GO:0072057 inner stripe development | |||
GO:0072058 outer stripe development | |||
GO:0072059 cortical collecting duct development | |||
GO:0072060 outer medullary collecting duct development | |||
GO:0072061 inner medullary collecting duct development | |||
GO:0072062 S1 cell differentiation | |||
GO:0072063 short descending thin limb development | |||
GO:0072064 long descending thin limb development | |||
GO:0072065 long descending thin limb bend development | |||
GO:0072066 prebend segment development | |||
GO:0072067 early distal convoluted tubule development | |||
GO:0072068 late distal convoluted tubule development | |||
GO:0072069 DCT cell differentiation | |||
GO:0072070 loop of Henle development | |||
GO:0072071 interstitial cell differentiation | |||
GO:0072072 kidney stroma development | |||
GO:0072073 kidney epithelium development | |||
GO:0072074 kidney mesenchyme development | |||
GO:0072075 metanephric mesenchyme development | |||
GO:0072076 nephrogenic mesenchyme development | |||
GO:0072077 renal vesicle morphogenesis | |||
GO:0072078 nephron tubule morphogenesis | |||
GO:0072079 nephron tubule formation | |||
GO:0072080 nephron tubule development | |||
GO:0072081 specification of nephron tubule identity | |||
GO:0072082 specification of proximal tubule identity | |||
GO:0072083 specification of intermediate tubule identity | |||
GO:0072084 specification of distal tubule identity | |||
GO:0072085 specification of connecting tubule identity | |||
GO:0072086 specification of loop of Henle identity | |||
GO:0072087 renal vesicle development | |||
GO:0072088 nephron epithelium morphogenesis | |||
GO:0072089 stem cell proliferation | |||
GO:0072090 mesenchymal stem cell proliferation involved in nephron morphogenesis | |||
GO:0072091 regulation of stem cell proliferation | |||
</pre> |
Revision as of 12:30, 8 February 2010
Please suggest agenda items, relevant papers and other information relating to kidney development GO terms that you would like discussed at this workshop, to enable us to form an agenda.
Participants
GO annotators | GO Editors | Kidney Development Experts |
---|---|---|
Dr Yasmin Alam-Faruque (GOA/EBI) Dr Emily Dimmer (GOA/EBI) Dr Rachael Huntley (GOA/EBI) Dr Rebecca Foulger (UniProt/Xenopus/EBI) Dr Susan Tweedie (Flybase/EBI) Dr Doug Howe (ZFIN/USA) (via Skype) |
Dr David Hill (Jax/USA) Dr Midori Harris (EBI) Dr Jane Lomax (EBI) |
Professor Adrian Woolf (ICH) Dr Duncan Davidson (GUDMAP) Professor Randall Thomas (IBISC CNRS) Professor Jamie Davies (GUDMAP) (available pm via phone/email if needed) Dr Bernard de Bono (Virtual Physiological Human, EBI) |
Location
EMBL-EBI, Room C202/203 - shared facilities, The Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD. Date: Monday 25th January 2010, 9:30am to 5pm
- Travel instructions to the EBI, The Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD [1]
- Further information about the on-site accommodation [2]
Programme
9:15am | Tea/ Coffee and Cookies | |
9:30am | Welcome and introduction | Yasmin |
9:35am | Introduction to GO | David Hill |
9:45am | Kidney precursor cells and tissues (segmentation) * Development of kidney field * Nephrogenic stem cell differentiation. * Sensing a quorum of cells / control of the number of cells in a cell group * (Mesonephric/metanephric) mesenchyme-epithelial transition * Formation of tight junctions/ adherens junctions/ basement membrane, * formation of pronephric-, mesonephric-, metanephric-specific terms? * SF 2859892: specification of kidney anlage *PMID 18715948 * SF 2860000: proximodistal kidney segmentation *PMID 17875669 *PMID 18715948 *PMID 12925600 * SF 2916204: mesenchymal cell differentiation involved in kidney development *PMID 12399320 and SF 2929915 mesenchymal cell differentiation involved in urinary tract development *PMID 17442697 * SF 2926832: metanephric + nephrogenic mesenchyme morphogenesis PMID 15342483 |
|
11am | Coffee break | |
11:20am | Kidney morphogenesis - Kidney structure formation * Cell morphogenesis * Formation of renal vesicle, * Formation of comma-shaped body/ S-shaped body/ glomerulus * Formation of mesangium, * Macula densa formation/ development * Oriented mitosis * SF 2860000: proximodistal kidney segmentation *PMID 17875669 *PMID 18715948 *PMID 12925600 * SF 2903833: kidney glomus development *PMID 10572058 * SF 2905937: Glomerular mesangium PMID 8910451 and PMID 10077614 * SF 2928268: specification of renal capsule PMID 15634693 |
|
12:30pm | Lunch @ on-site campus restaurant | |
1:30pm | Anatomical structure development/ formation * Epithelial patterning of the nephron epithelium: proximal/distal nephron tubule patterning/ specification/ identity/ development * Regulation of epithelial tubule diameter (is_a GO:0035296 regulation of tube diameter) * Morphogenesis of epithelial tubules * mesonephric tubule (anterior and posterior in mouse) * new children of GO:0002070 epithelial cell maturation: podocyte/ proximal tubule/ loop of Henle/ distal tubule/ connecting tubule cell differentiation (and other nephron cell types) * nephric duct/ tubule specification/ differentiation/ morphogenesis * Collecting duct system development/ formation/ differentiation * Connection of nephron tubule to collecting duct * Connecting tubule development; * SF 2902547: various kidney development terms *PMID 16790474 *PMID 18835385 * SF 2860000: proximodistal kidney segmentation *PMID 17875669 *PMID 18715948 *PMID 12925600 * SF 2907403 Podocyte development/ differentiation PMID 19050011 |
|
3pm | Coffee break | |
3:20pm | Continue with Anatomical structure development/ formation * kidney proximal tubule development/ specification; proximal convoluted tubule; * kidney intermediate tubule development/ identity/ specification:- thin descending limb; thin ascending limb; thick ascending limb; * kidney distal tubule development/ specification; distal convoluted tubule * Signalling to blood vessel-forming cells/ renal vasculature development (GO:0060684 epithelial-mesenchymal cell signaling?) * renal smooth muscle cell differentiation * SF 2902547: various kidney development terms *PMID 16790474 *PMID 18835385 * SF 2860000: proximodistal kidney segmentation *PMID 17875669 *PMID 18715948 *PMID 12925600 * SF 2903833: kidney glomus development *PMID 10572058 * SF 2929817 Ureter development *PMID 17442697 * SF 2930545 Glomerular capillary formation *PMID 18272846 |
|
5pm | Close |
KDM Minutes
Current Kidney Development Ontology Terms
The currently available kidney development process ontology (November 2009)
[[3]]
GO:0001656 GO:0001657 GO:0001658 GO:0001822 GO:0001823 GO:0032835 GO:0032836 GO:0034671 GO:0034672 GO:0048793 GO:0060675 GO:0060676 GO:0060677 GO:0060678 GO:0060679 GO:0060680 GO:0060681 GO:0060682
- chart [4]
Relevant papers and other resources
- Kidney Development Review Papers:
- Mammalian reviews:
- PMID 19906853 Advances in early kidney specification, development and patterning. Dressler M 2009. Talks about the essential roles of intrinsic nuclear factors and secreted signaling molecules in specifying renal epithelial stem cells and their self-renewal, in driving the complex dynamics of epithelial cell branching morphogenesis, and in nephron patterning.
- PMID 15554941 Transcriptional control of kidney development. Bouchard M. 2004. Talks about genes involved in nephric lineage specification (Pax2/Pax8/Lim1/Bmp4/Wt1/GDNF1/Eya1/Foxc1); metanephros development - UB positioning, induction, nephron induction, ureter branching, Stromal cell differentiation(Gdnf1/Eya1/Foxc1/2/Slit2/Robo2/Bmp4/Pax2/Hox11(HoxA11/C11/D11)/ Sall1/Wt1/Six1/Wnt4/Emx2/Gata3/BF2/Pod1/Pbx21.
- PMID 15380247 Recent genetic studies of mouse kidney development. Yu J, McMahon AP, Valerius MT. 2004. Has a nice diagram of the stages of nephron formation on p.551. Also lists genes investigated with particular molecular regulation of outgrowth of the uteric bud and regulation of tubulogenesis (Table 1; p552 - Gdf1, Six1, Slit2/Robo2, Wnt1, Fras1+Grip1, Pod1, Pbx1, Brn1, Psen1/2).
- PMID 16760375 Role of transcriptional networks in coordinating early events during kidney development. Boyle S, de Caestecker Mark. 2006. Has nice diagrams of stages of early mammalian kidney development. Reviews transcription factors in mesenephric mesenchyme: Eya1/ Foxc1/2/ Hoxa/c/d11/ Pax2/ Pbx1/ Rar-alpha/beta2/ Sall1/ Six1/ Wt1.
- PMID 12094231 Coordinating early kidney development: lessons from gene targeting. Vainio S, Lin Y. 2002. Nice diagrams of kidney development. List of genes essential for early kidney development (Transcription Factors: Emx2/Eya1/Foxc1/Foxd1/Pax2/Rara,Rarb/Sall1/Wt1; Growth factors: Bmp4/Bmp7/Fgf7/Gdnf/Wnt4; Growth factors/receptors: Gfra1/Notch2/Ret; Proteoglycans and their biosynthetic enzymes: Hs2st/Gpc3).
- Mammalian reviews:
- Other resources:
Notes
- Added KDM acronym to any NTR via SF relating to kidney development
- All KDM requests currently in SF [12]
- Related terms recently requested:
- SF 2932119 -ive regn of GO:0060681 PMID 17118062
- SF 2929886 BMP signaling involved in urinary tract segmentation PMID 17442697
- SF 2929817 ureter development/differentiation/morphogenesis PMID 17442697
- SF 2928381 ureteric peristalsis PMID 18776146
- Recently committed NTR nephrogenesis-related GO terms
- (SF 2884040 metanephric mesenchyme to epithelial transition terms *PMID 15843474) (November 2009).
- (SF 2907000 *PMID 10021330) Addition of 'Nephrogenesis' as a 'related' synonym of 'Kidney Development'. BMP4 (human) Induction of nephrogenesis: NTR: "nephric duct morphogenesis" and NTR "positive regulation of kidney development".(December 2009)
- (SF 2914121 +ive and -ive regulation of branching involved in ureteric bud morphogenesis and +ive and -ive regulation of glomerulus development PMID 12141440) (December 2009)
- SF 2930642 cellular response to dexamethasone stimulus PMID 17537984 (January 2010)
- GO:0060677 ureteric bud elongation (Def: The process by which the ureteric bud grows along its axis) - does this term cover ureteric bud invasion? (the initial key step of metanephros devpt, the ureteric bud invades the mesenchyme and induces epithelialization and differentiation of the mesenchyme into the glomeruli, the Loop of Henle and the proximal and distal tubules - see PMID 18470945|PMID 11688560). If so, need to improve definition.
- Keep an eye on definition compatability across species/taxa
Ontology Editing
Midori Harris and David Hill are working through terms added during the meeting and the SF items. The first changes from the meeting were committed to the live GO on February 8, 2010, in gene_ontology_write.obo revision 1.1010.
The changes committed are summarized below and in the CVS log, and shown in detail in two diff files, one generated by the obodiff utility and the other by the UNIX diff utility.
2010-02-08 confirmed definition of 'kidney development' GO:0001822; adjusted parentage definition adjustments: GO:0001759 induction of an organ GO:0061005 cell differentiation involved in kidney development added synonyms: GO:0061004 pattern specification involved in kidney development new terms: GO:0072001 renal system development GO:0072002 Malpighian tubule development GO:0072003 kidney rudiment formation GO:0072004 kidney field specification GO:0072005 maintenance of kidney identity GO:0072006 nephron development GO:0072007 mesangial cell differentiation GO:0072008 glomerular mesangial cell differentiation GO:0072009 nephron epithelium development GO:0072010 glomerular epithelium development GO:0072011 glomerular endothelium development GO:0072012 glomerulus vasculature development GO:0072013 glomus development GO:0072014 proximal tubule development GO:0072015 glomerular visceral epithelial cell development GO:0072016 glomerular parietal epithelial cell development GO:0072017 distal tubule development GO:0072018 intermediate tubule development GO:0072019 proximal convoluted tubule development GO:0072020 proximal straight tubule development GO:0072021 ascending thin limb development GO:0072022 descending thin limb development GO:0072023 thick ascending limb development GO:0072024 macula densa development GO:0072025 distal convoluted tubule development GO:0072026 distal straight tubule development GO:0072027 connecting tubule development GO:0072028 nephron morphogenesis GO:0072029 long nephron development GO:0072030 short nephron development GO:0072031 S1 development GO:0072032 S2 development GO:0072033 renal vesicle formation GO:0072034 positive regulation of renal vesicle formation GO:0072035 pre-tubular aggregate formation GO:0072036 mesenchymal to epithelial transition involved in renal vesicle formation GO:0072037 mesenchymal stem cell differentiation involved in nephron morphogenesis GO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis GO:0072039 regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis GO:0072040 negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis GO:0072041 positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis GO:0072042 regulation of mesenchymal stem cell proliferation involved in nephron morphogenesis GO:0072043 regulation of pre-tubular aggregate formation by cell-cell signaling GO:0072044 collecting duct development GO:0072045 convergent extension involved in nephron morphogenesis GO:0072046 establishment of planar polarity involved in nephron morphogenesis GO:0072047 proximal/distal pattern formation involved in nephron development GO:0072048 renal system pattern specification GO:0072049 comma-shaped body morphogenesis GO:0072050 S-shaped body morphogenesis GO:0072051 juxtaglomerular apparatus development GO:0072052 juxtaglomerulus cell differentiation GO:0072053 renal inner medulla development GO:0072054 renal outer medulla development GO:0072055 renal cortex development GO:0072056 pyramids development GO:0072057 inner stripe development GO:0072058 outer stripe development GO:0072059 cortical collecting duct development GO:0072060 outer medullary collecting duct development GO:0072061 inner medullary collecting duct development GO:0072062 S1 cell differentiation GO:0072063 short descending thin limb development GO:0072064 long descending thin limb development GO:0072065 long descending thin limb bend development GO:0072066 prebend segment development GO:0072067 early distal convoluted tubule development GO:0072068 late distal convoluted tubule development GO:0072069 DCT cell differentiation GO:0072070 loop of Henle development GO:0072071 interstitial cell differentiation GO:0072072 kidney stroma development GO:0072073 kidney epithelium development GO:0072074 kidney mesenchyme development GO:0072075 metanephric mesenchyme development GO:0072076 nephrogenic mesenchyme development GO:0072077 renal vesicle morphogenesis GO:0072078 nephron tubule morphogenesis GO:0072079 nephron tubule formation GO:0072080 nephron tubule development GO:0072081 specification of nephron tubule identity GO:0072082 specification of proximal tubule identity GO:0072083 specification of intermediate tubule identity GO:0072084 specification of distal tubule identity GO:0072085 specification of connecting tubule identity GO:0072086 specification of loop of Henle identity GO:0072087 renal vesicle development GO:0072088 nephron epithelium morphogenesis GO:0072089 stem cell proliferation GO:0072090 mesenchymal stem cell proliferation involved in nephron morphogenesis GO:0072091 regulation of stem cell proliferation