Kidney - Agenda for Kidney Development Ontology Content Meeting: Difference between revisions

Revision as of 07:05, 6 January 2011

Please suggest agenda items, relevant papers and other information relating to kidney development GO terms that you would like discussed at this workshop, to enable us to form an agenda.

Participants

GO annotators	GO Editors	Kidney Development Experts
Dr Yasmin Alam-Faruque (GOA/EBI) Dr Emily Dimmer (GOA/EBI) Dr Rachael Huntley (GOA/EBI) Dr Rebecca Foulger (UniProt/Xenopus/EBI) Dr Susan Tweedie (Flybase/EBI) Dr Doug Howe (ZFIN/USA) (via Skype)	Dr David Hill (Jax/USA) Dr Midori Harris (EBI) Dr Jane Lomax (EBI)	Professor Adrian Woolf (ICH) Dr Duncan Davidson (GUDMAP) Professor Randall Thomas (IBISC CNRS) Professor Jamie Davies (GUDMAP) (available pm via phone/email if needed) Dr Bernard de Bono (Virtual Physiological Human, EBI)

Location

EMBL-EBI, Room C202/203 - shared facilities, The Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD. Date: Monday 25th January 2010, 9:30am to 5pm

Travel instructions to the EBI, The Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD [1]
Further information about the on-site accommodation [2]

Programme

9:15am	Tea/ Coffee and Cookies
9:30am	Welcome and introduction	Yasmin
9:35am	Introduction to GO	David Hill
9:45am	Kidney precursor cells and tissues (segmentation) * Development of kidney field * Nephrogenic stem cell differentiation. * Sensing a quorum of cells / control of the number of cells in a cell group * (Mesonephric/metanephric) mesenchyme-epithelial transition * Formation of tight junctions/ adherens junctions/ basement membrane, * formation of pronephric-, mesonephric-, metanephric-specific terms? * SF 2859892: specification of kidney anlage PMID 18715948 SF 2860000: proximodistal kidney segmentation PMID 17875669 PMID 18715948 PMID 12925600 SF 2916204: mesenchymal cell differentiation involved in kidney development PMID 12399320 and SF 2929915 mesenchymal cell differentiation involved in urinary tract development PMID 17442697 * SF 2926832: metanephric + nephrogenic mesenchyme morphogenesis PMID 15342483
11am	Coffee break
11:20am	Kidney morphogenesis - Kidney structure formation * Cell morphogenesis * Formation of renal vesicle, * Formation of comma-shaped body/ S-shaped body/ glomerulus * Formation of mesangium, * Macula densa formation/ development * Oriented mitosis * SF 2860000: proximodistal kidney segmentation PMID 17875669 PMID 18715948 PMID 12925600 SF 2903833: kidney glomus development PMID 10572058 SF 2905937: Glomerular mesangium PMID 8910451 and PMID 10077614 * SF 2928268: specification of renal capsule PMID 15634693
12:30pm	Lunch @ on-site campus restaurant
1:30pm	Anatomical structure development/ formation * Epithelial patterning of the nephron epithelium: proximal/distal nephron tubule patterning/ specification/ identity/ development * Regulation of epithelial tubule diameter (is_a GO:0035296 regulation of tube diameter) * Morphogenesis of epithelial tubules * mesonephric tubule (anterior and posterior in mouse) * new children of GO:0002070 epithelial cell maturation: podocyte/ proximal tubule/ loop of Henle/ distal tubule/ connecting tubule cell differentiation (and other nephron cell types) * nephric duct/ tubule specification/ differentiation/ morphogenesis * Collecting duct system development/ formation/ differentiation * Connection of nephron tubule to collecting duct * Connecting tubule development; * SF 2902547: various kidney development terms PMID 16790474 PMID 18835385 * SF 2860000: proximodistal kidney segmentation PMID 17875669 PMID 18715948 PMID 12925600 SF 2907403 Podocyte development/ differentiation PMID 19050011
3pm	Coffee break
3:20pm	Continue with Anatomical structure development/ formation * kidney proximal tubule development/ specification; proximal convoluted tubule; * kidney intermediate tubule development/ identity/ specification:- thin descending limb; thin ascending limb; thick ascending limb; * kidney distal tubule development/ specification; distal convoluted tubule * Signalling to blood vessel-forming cells/ renal vasculature development (GO:0060684 epithelial-mesenchymal cell signaling?) * renal smooth muscle cell differentiation * SF 2902547: various kidney development terms PMID 16790474 PMID 18835385 * SF 2860000: proximodistal kidney segmentation PMID 17875669 PMID 18715948 PMID 12925600 SF 2903833: kidney glomus development PMID 10572058 SF 2929817 Ureter development PMID 17442697 SF 2930545 Glomerular capillary formation *PMID 18272846
5pm	Close

KDM Minutes

Current Kidney Development Ontology Terms

The currently available kidney development process ontology (November 2009) [[3]]
GO:0001656 GO:0001657 GO:0001658 GO:0001822 GO:0001823 GO:0032835 GO:0032836 GO:0034671 GO:0034672 GO:0048793 GO:0060675 GO:0060676 GO:0060677 GO:0060678 GO:0060679 GO:0060680 GO:0060681 GO:0060682

chart [4]

Relevant papers and other resources

Kidney Development Review Papers:
- Mammalian reviews:
  - PMID 19906853 Advances in early kidney specification, development and patterning. Dressler M 2009. Talks about the essential roles of intrinsic nuclear factors and secreted signaling molecules in specifying renal epithelial stem cells and their self-renewal, in driving the complex dynamics of epithelial cell branching morphogenesis, and in nephron patterning.
  - PMID 15554941 Transcriptional control of kidney development. Bouchard M. 2004. Talks about genes involved in nephric lineage specification (Pax2/Pax8/Lim1/Bmp4/Wt1/GDNF1/Eya1/Foxc1); metanephros development - UB positioning, induction, nephron induction, ureter branching, Stromal cell differentiation(Gdnf1/Eya1/Foxc1/2/Slit2/Robo2/Bmp4/Pax2/Hox11(HoxA11/C11/D11)/ Sall1/Wt1/Six1/Wnt4/Emx2/Gata3/BF2/Pod1/Pbx21.
  - PMID 15380247 Recent genetic studies of mouse kidney development. Yu J, McMahon AP, Valerius MT. 2004. Has a nice diagram of the stages of nephron formation on p.551. Also lists genes investigated with particular molecular regulation of outgrowth of the uteric bud and regulation of tubulogenesis (Table 1; p552 - Gdf1, Six1, Slit2/Robo2, Wnt1, Fras1+Grip1, Pod1, Pbx1, Brn1, Psen1/2).
  - PMID 16760375 Role of transcriptional networks in coordinating early events during kidney development. Boyle S, de Caestecker Mark. 2006. Has nice diagrams of stages of early mammalian kidney development. Reviews transcription factors in mesenephric mesenchyme: Eya1/ Foxc1/2/ Hoxa/c/d11/ Pax2/ Pbx1/ Rar-alpha/beta2/ Sall1/ Six1/ Wt1.
  - PMID 12094231 Coordinating early kidney development: lessons from gene targeting. Vainio S, Lin Y. 2002. Nice diagrams of kidney development. List of genes essential for early kidney development (Transcription Factors: Emx2/Eya1/Foxc1/Foxd1/Pax2/Rara,Rarb/Sall1/Wt1; Growth factors: Bmp4/Bmp7/Fgf7/Gdnf/Wnt4; Growth factors/receptors: Gfra1/Notch2/Ret; Proteoglycans and their biosynthetic enzymes: Hs2st/Gpc3).

Other resources:
- Kidney Development Websites:
  - Mouse Anatomy Browser - [5]
  - FMA human anatomy browser- [6]
  - GUDMAP browser - [7]
    - Metanephros [8]
    - renal vesicle [9]
- Kidney Development GO wiki [10]
- Loop of Henle GO Cocuration wiki [11]

Notes

Added KDM acronym to any NTR via SF relating to kidney development

All KDM requests currently in SF [12]

Related terms recently requested:
- SF 2932119 -ive regn of GO:0060681 PMID 17118062
- SF 2929886 BMP signaling involved in urinary tract segmentation PMID 17442697
- SF 2929817 ureter development/differentiation/morphogenesis PMID 17442697
- SF 2928381 ureteric peristalsis PMID 18776146

Recently committed NTR nephrogenesis-related GO terms
- (SF 2884040 metanephric mesenchyme to epithelial transition terms *PMID 15843474) (November 2009).
- (SF 2907000 *PMID 10021330) Addition of 'Nephrogenesis' as a 'related' synonym of 'Kidney Development'. BMP4 (human) Induction of nephrogenesis: NTR: "nephric duct morphogenesis" and NTR "positive regulation of kidney development".(December 2009)
- (SF 2914121 +ive and -ive regulation of branching involved in ureteric bud morphogenesis and +ive and -ive regulation of glomerulus development PMID 12141440) (December 2009)
- SF 2930642 cellular response to dexamethasone stimulus PMID 17537984 (January 2010)

GO:0060677 ureteric bud elongation (Def: The process by which the ureteric bud grows along its axis) - does this term cover ureteric bud invasion? (the initial key step of metanephros devpt, the ureteric bud invades the mesenchyme and induces epithelialization and differentiation of the mesenchyme into the glomeruli, the Loop of Henle and the proximal and distal tubules - see PMID 18470945|PMID 11688560). If so, need to improve definition.

Keep an eye on definition compatability across species/taxa

Ontology Editing

Midori Harris and David Hill are working through terms added during the meeting and the SF items. The first changes from the meeting were committed to the live GO on February 8, 2010, in gene_ontology_write.obo revision 1.1010.

The changes committed are summarized below and in the CVS log, and shown in detail in two diff files, one generated by the obodiff utility and the other by the UNIX diff utility.

February 8, 2010

2010-02-08

confirmed definition of 'kidney development' GO:0001822; adjusted parentage

definition adjustments:
 GO:0001759	induction of an organ
 GO:0061005	cell differentiation involved in kidney development

added synonyms:
  GO:0061004	pattern specification involved in kidney development

new terms:
  GO:0072001	renal system development
  GO:0072002	Malpighian tubule development
  GO:0072003	kidney rudiment formation
  GO:0072004	kidney field specification
  GO:0072005	maintenance of kidney identity
  GO:0072006	nephron development
  GO:0072007	mesangial cell differentiation
  GO:0072008	glomerular mesangial cell differentiation
  GO:0072009	nephron epithelium development
  GO:0072010	glomerular epithelium development
  GO:0072011	glomerular endothelium development
  GO:0072012	glomerulus vasculature development
  GO:0072013	glomus development
  GO:0072014	proximal tubule development
  GO:0072015	glomerular visceral epithelial cell development
  GO:0072016	glomerular parietal epithelial cell development
  GO:0072017	distal tubule development
  GO:0072018	intermediate tubule development
  GO:0072019	proximal convoluted tubule development
  GO:0072020	proximal straight tubule development
  GO:0072021	ascending thin limb development
  GO:0072022	descending thin limb development
  GO:0072023	thick ascending limb development
  GO:0072024	macula densa development
  GO:0072025	distal convoluted tubule development
  GO:0072026	distal straight tubule development
  GO:0072027	connecting tubule development
  GO:0072028	nephron morphogenesis
  GO:0072029	long nephron development
  GO:0072030	short nephron development
  GO:0072031	S1 development
  GO:0072032	S2 development
  GO:0072033	renal vesicle formation
  GO:0072034	positive regulation of renal vesicle formation
  GO:0072035	pre-tubular aggregate formation
  GO:0072036	mesenchymal to epithelial transition involved in renal vesicle formation
  GO:0072037	mesenchymal stem cell differentiation involved in nephron morphogenesis
  GO:0072038	mesenchymal stem cell maintenance involved in nephron morphogenesis
  GO:0072039	regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis
  GO:0072040	negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis
  GO:0072041	positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis
  GO:0072042	regulation of mesenchymal stem cell proliferation involved in nephron morphogenesis
  GO:0072043	regulation of pre-tubular aggregate formation by cell-cell signaling
  GO:0072044	collecting duct development
  GO:0072045	convergent extension involved in nephron morphogenesis
  GO:0072046	establishment of planar polarity involved in nephron morphogenesis
  GO:0072047	proximal/distal pattern formation involved in nephron development
  GO:0072048	renal system pattern specification
  GO:0072049	comma-shaped body morphogenesis
  GO:0072050	S-shaped body morphogenesis
  GO:0072051	juxtaglomerular apparatus development
  GO:0072052	juxtaglomerulus cell differentiation
  GO:0072053	renal inner medulla development
  GO:0072054	renal outer medulla development
  GO:0072055	renal cortex development
  GO:0072056	pyramids development
  GO:0072057	inner stripe development
  GO:0072058	outer stripe development
  GO:0072059	cortical collecting duct development
  GO:0072060	outer medullary collecting duct development
  GO:0072061	inner medullary collecting duct development
  GO:0072062	S1 cell differentiation
  GO:0072063	short descending thin limb development
  GO:0072064	long descending thin limb development
  GO:0072065	long descending thin limb bend development
  GO:0072066	prebend segment development
  GO:0072067	early distal convoluted tubule development
  GO:0072068	late distal convoluted tubule development
  GO:0072069	DCT cell differentiation
  GO:0072070	loop of Henle development
  GO:0072071	interstitial cell differentiation
  GO:0072072	kidney stroma development
  GO:0072073	kidney epithelium development
  GO:0072074	kidney mesenchyme development
  GO:0072075	metanephric mesenchyme development
  GO:0072076	nephrogenic mesenchyme development
  GO:0072077	renal vesicle morphogenesis
  GO:0072078	nephron tubule morphogenesis
  GO:0072079	nephron tubule formation
  GO:0072080	nephron tubule development
  GO:0072081	specification of nephron tubule identity
  GO:0072082	specification of proximal tubule identity
  GO:0072083	specification of intermediate tubule identity
  GO:0072084	specification of distal tubule identity
  GO:0072085	specification of connecting tubule identity
  GO:0072086	specification of loop of Henle identity
  GO:0072087	renal vesicle development
  GO:0072088	nephron epithelium morphogenesis
  GO:0072089	stem cell proliferation
  GO:0072090	mesenchymal stem cell proliferation involved in nephron morphogenesis
  GO:0072091	regulation of stem cell proliferation

February 22, 2010

Added new terms for these SF items (more information in comments):

March 2010

Metanephros specific terms

 GO:0072203	cell proliferation involved in metanephros development
 GO:0072204	cell-cell signaling involved in metanephros development
 GO:0072205	metanephric collecting duct development
 GO:0072206	metanephric juxtaglomerular apparatus development
 GO:0072207	metanephric epithelium development
 GO:0072208	metanephric smooth muscle tissue development
 GO:0072209	metanephric mesangial cell differentiation
 GO:0072210	metanephric nephron development
 GO:0072211	metanephric pyramids development
 GO:0072212	regulation of transcription from RNA polymerase II promoter involved in metanephros development
 GO:0072213	metanephric capsule development
 GO:0072214	metanephric cortex development
 GO:0072215	regulation of metanephros development
 GO:0072216	positive regulation of metanephros development
 GO:0072217	negative regulation of metanephros development
 GO:0072218	metanephric ascending thin limb development
 GO:0072219	metanephric cortical collecting duct development
 GO:0072220	metanephric descending thin limb development
 GO:0072221	metanephric distal convoluted tubule development
 GO:0072222	metanephric early distal convoluted tubule development
 GO:0072223	metanephric glomerular mesangium development
 GO:0072224	metanephric glomerulus development
 GO:0072225	metanephric late distal convoluted tubule development
 GO:0072226	metanephric long descending thin limb bend development
 GO:0072227	metanephric macula densa development
 GO:0072228	metanephric prebend segment development
 GO:0072229	metanephric proximal convoluted tubule development
 GO:0072230	metanephric proximal straight tubule development
 GO:0072231	metanephric S1 development
 GO:0072232	metanephric S2 development
 GO:0072233	metanephric thick ascending limb development
 GO:0072234	metanephric nephron tubule development
 GO:0072235	metanephric distal tubule development
 GO:0072236	metanephric loop of Henle development
 GO:0072237	metanephric proximal tubule development
 GO:0072238	metanephric long nephron development
 GO:0072239	metanephric glomerulus vasculature development
 GO:0072240	metanephric DCT cell differentiation
 GO:0072241	metanephric DCT cell development
 GO:0072242	metanephric DCT cell fate commitment
 GO:0072243	metanephric nephron epithelium development
 GO:0072244	metanephric glomerular epithelium development
 GO:0072245	metanephric glomerular parietal epithelial cell differentiation
 GO:0072246	metanephric glomerular parietal epithelial cell development
 GO:0072247	metanephric glomerular parietal epithelial cell fate commitment
 GO:0072248	metanephric glomerular visceral epithelial cell differentiation
 GO:0072249	metanephric glomerular visceral epithelial cell development
 GO:0072250	metanephric glomerular visceral epithelial cell fate commitment
 GO:0072251	metanephric juxtaglomerulus cell differentiation
 GO:0072252	metanephric juxtaglomerulus cell development
 GO:0072253	metanephric juxtaglomerulus cell fate commitment
 GO:0072254	metanephric glomerular mesangial cell differentiation
 GO:0072255	metanephric glomerular mesangial cell development
 GO:0072256	metanephric glomerular mesangial cell fate commitment
 GO:0072257	metanephric nephron tubule epithelial cell differentiation
 GO:0072258	metanephric interstitial cell differentiation
 GO:0072259	metanephric interstitial cell development
 GO:0072260	metanephric interstitial cell fate commitment
 GO:0072261	metanephric extraglomerular mesangial cell proliferation
 GO:0072262	metanephric glomerular mesangial cell proliferation
 GO:0072263	metanephric intraglomerular mesangial cell proliferation
 GO:0072264	metanephric glomerular endothelium development
 GO:0072265	metanephric capsule morphogenesis
 GO:0072266	metanephric capsule formation
 GO:0072267	metanephric capsule specification
 GO:0072268	pattern specification involved in metanephros development
 GO:0072269	metanephric long descending thin limb development
 GO:0072270	metanephric short nephron development
 GO:0072271	metanephric short descending thin limb development
 GO:0072272	proximal/distal pattern formation involved in metanephric nephron development
 GO:0072273	metanephric nephron morphogenesis
 GO:0072274	metanephric glomerular basement membrane development
 GO:0072275	metanephric glomerulus morphogenesis
 GO:0072276	metanephric glomerulus vasculature morphogenesis
 GO:0072277	metanephric glomerular capillary formation
 GO:0072278	metanephric comma-shaped body morphogenesis
 GO:0072279	convergent extension involved in metanephric nephron morphogenesis
 GO:0072280	establishment of planar polarity involved in metanephric nephron morphogenesis
 GO:0072281	mesenchymal stem cell differentiation involved in metanephric nephron morphogenesis
 GO:0072282	metanephric nephron tubule morphogenesis
 GO:0072283	metanephric renal vesicle morphogenesis
 GO:0072284	metanephric S-shaped body morphogenesis
 GO:0072285	mesenchymal to epithelial transition involved in metanephric renal vesicle formation
 GO:0072286	metanephric connecting tubule development
 GO:0072287	metanephric distal tubule morphogenesis
 GO:0072288	metanephric proximal tubule morphogenesis
 GO:0072289	metanephric nephron tubule formation
 GO:0072290	epithelial cell migration involved in metanephric nephron tubule morphogenesis
 GO:0072291	epithelial cell migration involved in metanephric distal tubule morphogenesis
 GO:0072292	epithelial cell migration involved in metanephric proximal tubule morphogenesis
 GO:0072293	specification of metanephric nephron tubule identity
 GO:0072294	specification of metanephric connecting tubule identity
 GO:0072295	specification of metanephric distal tubule identity
 GO:0072296	specification of metanephric loop of Henle identity
 GO:0072297	specification of metanephric proximal tubule identity
 GO:0072298	regulation of metanephric glomerulus development
 GO:0072299	negative regulation of metanephric glomerulus development
 GO:0072300	positive regulation of metanephric glomerulus development
 GO:0072301	regulation of metanephric glomerular mesangial cell proliferation
 GO:0072302	negative regulation of metanephric glomerular mesangial cell proliferation
 GO:0072303	positive regulation of glomerular metanephric mesangial cell proliferation
 GO:0072304	regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis
 GO:0072305	negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis
 GO:0072306	positive regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis
 GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
 GO:0072308	negative regulation of metanephric nephron tubule epithelial cell differentiation
 GO:0072309	mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
 GO:0072310	glomerular epithelial cell development
 GO:0072311	glomerular epithelial cell differentiation
 GO:0072312	metanephric glomerular epithelial cell differentiation
 GO:0072313	metanephric glomerular epithelial cell development
 GO:0072314	glomerular epithelial cell fate commitment
 GO:0072315	metanephric glomerular epithelial cell fate commitment
 GO:0072185	metanephric cap development
 GO:0072186	metanephric cap morphogenesis
 GO:0072187	metanephric cap formation
 GO:0072188	metanephric cap specification
 GO:0072203	cell proliferation involved in metanephros development
 GO:0072204	cell-cell signaling involved in metanephros development
 GO:0072170	metanephric tubule development
 GO:0072171	mesonephric tubule morphogenesis
 GO:0072172	mesonephric tubule formation
 GO:0072173	metanephric tubule morphogenesis
 GO:0072174	metanephric tubule formation
 GO:0072162	metanephric mesenchymal cell differentiation
 GO:0072136	metanephric mesenchymal cell proliferation
 GO:0072133	metanephric mesenchyme morphogenesis
 GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
 GO:0072075	metanephric mesenchyme development

August 2010

Mesonephros specific terms

GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0072165 anterior mesonephric tubule development GO:0072166 posterior mesonephric tubule development GO:0072167 specification of mesonephric tubule identity GO:0072168 specification of anterior mesonephric tubule identity GO:0072169 specification of posterior mesonephric tubule identity GO:0072171 mesonephric tubule morphogenesis GO:0072172 mesonephric tubule formation GO:0072177 mesonephric duct development GO:0072180 mesonephric duct morphogenesis GO:0072181 mesonephric duct formation GO:0061206 mesonephros morphogenesis GO:0061207 mesonephric juxtaglomerulus cell differentiation GO:0061208 cell differentiation involved in mesonephros development GO:0061209 cell proliferation involved in mesonephros development GO:0061210 cell-cell signaling involved in mesonephros development GO:0061211 mesonephric collecting duct development GO:0061212 mesonephric juxtaglomerular apparatus development GO:0061213 positive regulation of mesonephros development GO:0061214 mesonephric smooth muscle tissue development GO:0061215 mesonephric nephron development GO:0061216 regulation of transcription from RNA polymerase II promoter involved in mesonephros development GO:0061217 regulation of mesonephros development GO:0061218 negative regulation of mesonephros development GO:0061219 mesonephric mesenchyme development GO:0061220 mesonephric macula densa development GO:0061221 mesonephric mesenchyme morphogenesis GO:0061222 mesonephric mesenchymal cell proliferation GO:0061223 mesonephric mesenchymal cell differentiation GO:0061224 mesonephric glomerulus development GO:0061225 mesonephric extraglomerular mesangial cell proliferation GO:0061226 proximal/distal pattern specification involved in mesonephric nephron development GO:0061227 pattern specification involved in mesonephros development GO:0061228 mesonephric nephron morphogenesis GO:0061229 mesonephric juxtaglomerulus cell development GO:0061230 mesonephric juxtaglomerulus cell fate commitment GO:0061231 mesonephric glomerulus vasculature development GO:0061232 mesonephric glomerular epithelium development GO:0061233 mesonephric glomerular basement membrane development GO:0061234 mesonephric glomerulus morphogenesis GO:0061235 mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis GO:0061236 mesonephric comma-shaped body morphogenesis GO:0061237 convergent extension involved in mesonephric nephron morphogenesis GO:0061238 establishment of planar polarity involved in mesonephric nephron morphogenesis GO:0061239 mesenchymal stem cell differentiation involved in mesonephric nephron morphogenesis GO:0061240 mesonephric nephron tubule morphogenesis GO:0061241 nephron epithelium development GO:0061242 mesonephric nephron tubule development GO:0061243 mesonephric renal vesicle morphogenesis GO:0061244 mesonephric S-shaped body morphogenesis GO:0061247 mesonephric glomerular mesangium development GO:0061248 mesonephric glomerulus vasculature morphogenesis GO:0061249 mesonephric glomerular capillary formation GO:0061250 mesonephric glomerular epithelial cell differentiation GO:0061251 mesonephric glomerular epithelial cell development GO:0061252 mesonephric glomerular epithelial cell fate commitment GO:0061253 mesonephric glomerular parietal epithelial cell differentiation GO:0061254 mesonephric glomerular parietal epithelial cell development GO:0061255 mesonephric glomerular parietal epithelial cell fate commitment GO:0061256 mesonephric glomerular visceral epithelial cell differentiation GO:0061257 mesonephric glomerular visceral epithelial cell development GO:0061258 mesonephric glomerular visceral epithelial cell fate commitment GO:0061259 mesonephric glomerular mesangial cell differentiation GO:0061260 mesonephric mesangial cell differentiation GO:0061261 mesenchymal to epithelial transition involved in mesonephros morphogenesis GO:0061262 mesonephric renal vesicle formation GO:0061263 mesonephric glomerular mesangial cell development GO:0061264 mesonephric glomerular mesangial cell fate commitment GO:0061265 mesonephric nephron tubule epithelial cell differentiation GO:0061266 mesonephric interstitial cell differentiation GO:0061267 mesonephric interstitial cell development GO:0061268 mesonephric interstitial cell fate commitment GO:0061269 mesonephric glomerular mesangial cell proliferation GO:0061270 mesonephric intraglomerular mesangial cell proliferation GO:0061271 mesenchymal to epithelial transition involved in mesonephric renal vesicle formation GO:0061272 mesonephric connecting tubule development GO:0061273 mesonephric distal tubule morphogenesis GO:0061274 mesonephric distal tubule development GO:0061275 mesonephric proximal tubule development GO:0061276 mesonephric proximal tubule morphogenesis GO:0061277 mesonephric nephron tubule formation GO:0061278 epithelial cell migration involved in mesonephric nephron tubule morphogenesis GO:0061279 epithelial cell migration involved in mesonephric distal tubule morphogenesis GO:0061280 epithelial cell migration involved in mesonephric proximal tubule morphogenesis GO:0061281 specification of mesonephric connecting tubule identity GO:0061282 specification of mesonephric nephron tubule identity GO:0061283 specification of mesonephric distal tubule identity GO:0061284 specification of mesonephric proximal tubule identity GO:0061285 mesonephric capsule development GO:0061286 mesonephric capsule morphogenesis GO:0061287 mesonephric capsule formation GO:0061288 mesonephric capsule specification GO:0061289 Wnt receptor signaling pathway involved in kidney development GO:0061290 canonical Wnt receptor signaling pathway involved in metanephric kidney development GO:0061291 canonical Wnt receptor signaling pathway involved in ureteric bud branching GO:0061292 canonical Wnt receptor signaling pathway involved in mesonephros development GO:0061293 canonical Wnt receptor signaling pathway involved in mesonephric nephron development GO:0061294 mesonephric renal vesicle induction GO:0061295 regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis GO:0061296 negative regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis GO:0061297 positive regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis

September 2010

Pronephros specific terms

GO:0039003 pronephric field specification GO:0039004 specification of pronephric proximal tubule identity GO:0039005 specification of pronephric tubule identity GO:0039006 pronephric nephron tubule formation GO:0039007 pronephric nephron morphogenesis GO:0039008 pronephric nephron tubule morphogenesis GO:0039009 rectal diverticulum development GO:0039010 specification of pronephric distal tubule identity GO:0039011 pronephric proximal tubule morphogenesis GO:0039012 pronephric sinus development GO:0039013 pronephric distal tubule morphogenesis GO:0039014 cell differentiation involved in pronephros development GO:0039015 cell proliferation involved in pronephros development GO:0039016 cell-cell signaling involved in pronephros development GO:0039017 pattern specification involved in pronephros development GO:0039018 nephrostome development GO:0039019 pronephric nephron development GO:0039020 pronephric nephron tubule development GO:0039021 pronephric glomerulus development GO:0039022 pronephric duct development GO:0039023 pronephric duct morphogenesis GO:0072114 pronephros morphogenesis GO:0072116 pronephros formation GO:0072120 pronephros maturation

November 2010

Insect renal system specific terms

GO:0061318 renal filtration cell differentiation GO:0061319 nephrocyte differentiation GO:0061320 pericardial nephrocyte differentiation GO:0061321 garland nephrocyte differentiation GO:0061322 disseminated nephrocyte differentiation GO:0061326 renal tubule development GO:0061327 anterior Malpighian tubule development GO:0061328 posterior Malpighian tubule development GO:0061329 Malpighian tubule principle cell differentiation GO:0061330 Malpighian tubule stellate cell differentiation GO:0061331 cell proliferation involved in Malpighian tubule morphogenesis GO:0061332 Malpighian tubule bud morphogenesis GO:0061333 renal tubule morphogenesis GO:0061334 cell migration involved in Malpighian tubule morphogenesis GO:0061335 cell growth involved in Malpighian tubule morphogenesis GO:0061336 cell morphogenesis involved in Malpighian tubule morphogenesis GO:0061352 cell chemotaxis involved in Malpighian tubule morphogenesis GO:0061353 transforming growth factor beta receptor signaling pathway involved in Malpighian tubule cell chemotaxis