LEGO May 18, 2015: Difference between revisions
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===March Paper - Modeling the Mitotic Exit Network=== | ===March Paper - Modeling the Mitotic Exit Network=== | ||
* Additional reading: [http://www.ncbi.nlm.nih.gov/pubmed/24594661 The Mitotic Exit Network: new turns on old pathways.] | * Additional reading: [http://www.ncbi.nlm.nih.gov/pubmed/24594661 The Mitotic Exit Network: new turns on old pathways.] | ||
* Steps/functions | * Steps/functions to model: | ||
** | ** Tem1 localizes to the spindle pole body | ||
** Tem1 and Cdc15 physically interact in a manner dependent on Tem1's GTP-binding domain | ** Tem1 and Cdc15 physically interact in a manner dependent on Tem1's GTP-binding domain | ||
** Bfa1/Bub2 complex positively regulates Tem1 GTPase activity, resulting in decreased GTP binding | |||
** Tem1 is required for Cdc15 localization to the spindle pole body during late anaphase | ** Tem1 is required for Cdc15 localization to the spindle pole body during late anaphase | ||
** Cdc15 | ** Cdc15 phosphorylates Dbf2 only when Dbf2 is present with Mob1 | ||
** Dbf2 | |||
[[Category:LEGO]] | [[Category:LEGO]] | ||
Revision as of 10:51, 15 May 2015
Action Items from May 4, 2015 Call
- Make a github ticket for adding IntAct protein complexes to Noctua. [DONE]
- Heiko will let Seth know that curators may add feature requests, but these are not immediate needs.
- David, Kimberly, and Rama will review their March paper models to compare with Paul's version.
- Continue to work on LEGO model for the April consistency exercise - http://www.ncbi.nlm.nih.gov/pubmed/24349431
March Paper - Modeling the Mitotic Exit Network
- Additional reading: The Mitotic Exit Network: new turns on old pathways.
- Steps/functions to model:
- Tem1 localizes to the spindle pole body
- Tem1 and Cdc15 physically interact in a manner dependent on Tem1's GTP-binding domain
- Bfa1/Bub2 complex positively regulates Tem1 GTPase activity, resulting in decreased GTP binding
- Tem1 is required for Cdc15 localization to the spindle pole body during late anaphase
- Cdc15 phosphorylates Dbf2 only when Dbf2 is present with Mob1
- Dbf2