LEGO May 4 2015

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Agenda

Continued Discussion of March Consistency Exercise Paper

Specific Questions/Issues

  • Use of in_absence_of and in_presence_of annotation extensions.
  • How to adequately capture the effects of protein binding on subsequent complex formation and resulting molecular functions.


Begin Discussion of April Consistency Exercise Paper

Specific Questions/Issues

  • Use of occurs_in relation for molecular function annotations
    • What constitutes sufficient evidence for adding this extension, as CC annotations may be from a different experiment than the MF annotation?
    • For example, protein binding based on Y2H or whole cell lysates (IPI) with separate experiments describing localization (IDA).