Difference between revisions of "MGI"

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[[Category:MGI]]
 
= Mouse Genome Informatics Summary, 2010 =
 
= Mouse Genome Informatics Summary, 2010 =
lasted edited 9-14-10 by hjd
 
  
 
= Overview =
 
= Overview =
Line 30: Line 30:
  
 
<center>'''MGI GO STATS as of December, 2010'''</center>
 
<center>'''MGI GO STATS as of December, 2010'''</center>
 
  
  
 
{| style="border-spacing:0;"
 
{| style="border-spacing:0;"
| style="border-top:0.0007in solid #000000;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| '''Annotation Type'''
+
| style="border-top:0.0139in solid #000000;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| '''Annotation Type'''  
| style="border-top:0.0007in solid #000000;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| '''09_Dec_10'''
+
| style="border-top:0.0139in solid #000000;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| '''01_Dec_10'''  
| style="border-top:0.0007in solid #000000;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| '''09_Dec_09'''
+
| style="border-top:0.0139in solid #000000;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| '''09_Dec_09'''  
| style="border-top:0.0007in solid #000000;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| '''Change'''
+
| style="border-top:0.0139in solid #000000;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| '''Change'''  
| style="border:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| '''% Change'''
+
| style="border:0.0139in solid #000000;padding:0.0201in;"| '''% Change'''  
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"|  
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| Total Genes annotated (with at least one GO term of any kind):
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| Total Genes annotated (with at least one GO term of any kind):  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">34200*</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">33906*</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">18207</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">18207</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">15993</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">15699</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">87.84</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"| <div align="right">86.23</div>
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"|  
  
 
|-
 
|-
| colspan="5"  style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| Total Manual Annotation
+
| colspan="5"  style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"| Total Manual Annotation  
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| Number of Genes
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| Number of Genes  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">32410</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">32670</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">11668</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">11668</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">20742</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">21002</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">177.77</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"| <div align="right">180</div>
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"|  
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| Orthology:
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| Orthology:  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">4214</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">8187</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">752</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">752</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">3462</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">7435</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">460.37</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"| <div align="right">988.7</div>
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"|  
  
 
|-
 
|-
| colspan="5"  style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| IEA Annotation
+
| colspan="5"  style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"| IEA Annotation  
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"|  
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| SwissProt to GO
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| SwissProt to GO  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">15667</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">15690</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">16050</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">16050</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">tbc</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">-360</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">tbc</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"| <div align="right">-2.24</div>
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"|  
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| Interpro to GO
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| Interpro to GO  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">10514</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">10530</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">10749</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">10749</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">tbc</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">-219</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">tbc</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"| <div align="right">-2.04</div>
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"|  
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| EC to GO
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| EC to GO  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">1414</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">1033</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">1510</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">1510</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">tbc</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <div align="right">-447</div>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <div align="right">tbc</div>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"| <div align="right">-31.59</div>
  
 
|-
 
|-
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"| <nowiki>* 100% of current gene models</nowiki>
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"| <nowiki>* 100% of current gene models </nowiki>
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:none;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:none;padding:0.0201in;"|  
| style="border-top:none;border-bottom:0.0007in solid #000000;border-left:0.0007in solid #000000;border-right:0.0007in solid #000000;padding-top:0in;padding-bottom:0in;padding-left:0.075in;padding-right:0.075in;"|  
+
| style="border-top:none;border-bottom:0.0139in solid #000000;border-left:0.0139in solid #000000;border-right:0.0139in solid #000000;padding:0.0201in;"|  
  
 
|}
 
|}
 +
  
  
 
The large changes in manual (non-IEA) curated genes are the result of the addition of 5 efforts.
 
The large changes in manual (non-IEA) curated genes are the result of the addition of 5 efforts.
 
# Annotating genes with no literature annotation to one or more of the three roots. Quality control reports now alert curators for any genes annotated to one or more of the three roots when new literature is added to MGI and the literature is indexed to these genes.
 
# Annotating genes with no literature annotation to one or more of the three roots. Quality control reports now alert curators for any genes annotated to one or more of the three roots when new literature is added to MGI and the literature is indexed to these genes.
# We have added a pipeline to create annotations inferred by sequence orthology (ISO) to mouse genes that have rat orthologs where the rat  orthologs have been annotated by experiment.
+
# We have added a pipeline to create annotations inferred by sequence orthology (ISO) to mouse genes that have rat or human orthologs where the rat or human orthologs have been annotated by experiment.
 
# We have added a pipeline to load GOA annotations to mouse genes.
 
# We have added a pipeline to load GOA annotations to mouse genes.
 
# We have added a pipeline to add annotations based on intra-ontology relationships.
 
# We have added a pipeline to add annotations based on intra-ontology relationships.
# We have added a pipeline to add annotations by on sequence similarity (ISS)based on Panther family membership via the Reference Genome projet.
+
# We have added a pipeline to add annotations by on sequence similarity (ISS)based on Panther family membership via the Reference Genome project.
 +
 
  
 
==Methods and strategies for annotation==
 
==Methods and strategies for annotation==
Line 177: Line 178:
  
 
= Presentations and Publications =
 
= Presentations and Publications =
**[[GO 2009 Publications, Tutorials & Workshops, Presentations, Posters, and Resources]] this is for 2009
+
*[[Publications,_Talks,_Posters_2010-]] (for all GOC)
  
We either need a 2010 master (appears not to exist?). OR MGI should but following here. listing anything from Dec 2009 to now
 
  
Publications
+
*Publications
 +
Gene Ontology Consortium. The Gene Ontology in 2010: extensions and refinements. Nucleic Acids Res. 2010 Jan;38(Database issue):D331-5. NAR
  
 +
Hill DP, Berardini TZ, Howe DG, Van Auken KM. Representing ontogeny through ontology: a developmental biologist's guide to the gene ontology. Mol Reprod Dev 2010; 77(4):314-29.
  
Tutorials and Workshops
+
Alterovitz G, Xiang M, Hill DP, Lomax J, Liu J, Cherkassky M, Dreyfuss J, Mungall C, Harris MA, Dolan ME, Blake JA, Ramoni MF.
 +
Ontology engineering.Nat Biotechnol. 2010 Feb;28(2):128-30.
  
Posters
+
*Tutorials and Workshops
 +
 
 +
*Posters
 +
Drabkin HJ et al. (MGI), Title: "Proteins, Pathways, and Macromolecular Complexes"; ISMB (July 2010)
  
 
= A. Ontology Development Contributions:=
 
= A. Ontology Development Contributions:=
Line 192: Line 198:
  
 
*1. David Hill has worked on a team with Tanya Berardini, Chris Mungall, Midori Harris and Jane Lomax to develop cross-products within and among the three GO namespaces.
 
*1. David Hill has worked on a team with Tanya Berardini, Chris Mungall, Midori Harris and Jane Lomax to develop cross-products within and among the three GO namespaces.
 
+
*2. David Hill continues to work with Chris Mungall and Tanya Berardini to add inter-ontology links in GO.
 
 
*2. David Hill continues to work with Chris Mungall and Tanya Berardini to inter-ontology links in GO.
 
 
 
 
 
 
*3. David Hill has worked with Yasmin Alam-Faruque, Doug Howe, Midori Harris, Susan Tweedie, Becky Foulger and community experts to expand the kidney development portion of GO.
 
*3. David Hill has worked with Yasmin Alam-Faruque, Doug Howe, Midori Harris, Susan Tweedie, Becky Foulger and community experts to expand the kidney development portion of GO.
 
+
*4. Alexander Diehl is project leader for the Cell Ontology (with Chris Mungall) and Terry Meehan is a full-time curator working on the Cell Ontology. Terry has finished implementing cross-products for hematopoietic cell ontology terms and is working on general improvements to the CL, and has moved on to import of FMA cell types, among others.  Alex is focusing improvements to the representation of neurons in the CL, part of an ongoing collaboration with the International Neuroinformatics Framework (INCF). In May 2010 we held a very successful Cell Ontology Workshop at The Jackson Laboratory where many issues regarding the longterm development of the ontology were settled. We will hold another workshop on neurons in the first quarter of 2011.  (See separate progress report for the Cell Ontology).  In summer 2010 Alex mentored Morgan V. Hightshoe, a returned member of the Jackson Laboratory Summer Student Program, and Wade Valleau, a local high school intern in linked projects to revise the representation of nervous system cell types in the Cells Ontology.  Wade received support from INCF for his work. Alex continues to act as the GOC liaison to the Infectious Disease Ontology and Vaccine Ontology groups and to act on term requests for the GO from those groups, and is active in the GO Signaling and Virus content development groups.
 
+
*5. David Hill and Jane Lomax oversee the biological content development of GO. In particular, all new developmental biology-related terms submitted to SourceForge are handled by David Hill.
*4. Alexander Diehl is active in the GO Signaling and Virus content development groups.
+
*6. David Hill and Harold Drabkin have been working with Tanya Berardini, Chris Mungall, Midori Harris, Jane Lomax and ChEBI curators to align GO with ChEBI. This will result in the first set of cross-products with GO and an external ontology.
 
+
*7. David Hill and Karen Christie have been collaborating to revise and update the transcription area of GO.<br><br>
 
 
*5. Alexander Diehl continues to act as the GOC liaison to the Infectious Disease Ontology and Vaccine Ontology groups and to act on term requests for the GO from those groups.
 
 
 
 
 
*6. Alexander Diehl is project leader for the Cell Ontology (with Chris Mungall) and Terry Meehan is a full-time curator working on the Cell Ontology. Terry has finished implementing cross-products for hematopoietic cell ontology terms and is working on general improvements to the CL, and has moved on to import of FMA cell types, among others.  Alex is focusing improvements to the representation of neurons in the CL, part of an ongoing collaboration with the International Neuroinformatics Framework (INCF). In May 2010 we held a very successful Cell Ontology Workshop at The Jackson Laboratory where many issues regarding the longterm development of the ontology were settled. We will hold another workshop on neurons in the first quarter of 2011.  (See separate progress report for the Cell Ontology)
 
 
 
 
 
*7.  In summer 2010 Alexander Diehl mentored Morgan V. Hightshoe, a returned member of the Jackson Laboratory Summer Student Program, and Wade Valleau, a local high school intern in linked projects to revise the representation of nervous system cell types in the Cells Ontology.  Wade received support from INCF for his work..
 
 
 
 
 
*8. David Hill and Jane Lomax oversee the biological content development of GO. In particular, all new developmental biology-related terms submitted to SourceForge are handled by David Hill and all new 'regulation' terms are handled by David Hill and Tanya Berardini.<br><br>
 
  
 
= Annotation Outreach and User Advocacy Efforts: =
 
= Annotation Outreach and User Advocacy Efforts: =
 
* The Protein Ontology project continues to provide a web interface (http/pir.georgetown.edu/cgi-bin/pro/race_pro) whereby functional annotation using the GO can be applied to PRO submissions. These are reviewed by Cecilia Arighi of Georgetown. At present, only the PRO curators (Georgetown and MGI) are using the tool, but it is available to anyone.
 
* The Protein Ontology project continues to provide a web interface (http/pir.georgetown.edu/cgi-bin/pro/race_pro) whereby functional annotation using the GO can be applied to PRO submissions. These are reviewed by Cecilia Arighi of Georgetown. At present, only the PRO curators (Georgetown and MGI) are using the tool, but it is available to anyone.
* Harold is mentoring to curators in Donna Slonim's group at Tufts, Heather Wick and Craig Fournier. They are focusing on genes involved in human fetal development.
+
* Harold is mentoring two curators in Donna Slonim's group at Tufts, Heather Wick and Craig Fournier. They are focusing on genes involved in human fetal development.
 
* David Hill continues to serve on the GO-help rota.
 
* David Hill continues to serve on the GO-help rota.
  
 
= Other Highlights: =
 
= Other Highlights: =
We are now suppling a GAF 2.0 format file to GOC with column 16 cell type and column 17 isoform data filled in. This file is also available directly from our own FTP site.
+
*We are now suppling a GAF 2.0 format file to GOC with column 16 cell type and column 17 isoform data filled in. This file is also available directly from our own FTP site.
  
*Dmitry Sitnikov continues collaboration with Larry Hunter's group (Dr. Mike Bada) to establish a large, high-quality, corpora of full-text publications, expertly annotated with expressive knowledge representations, to improve the performance of a wide variety of biochemical text mining systems and to create new approaches to text mining. This involves systematically training and evaluating a broad sample of information extraction methods for key tasks, including concept and relationship identification. This effort can also be useful in synonym improvements to the GO between GO terms and certain biological concepts and terminology used in the literature. So far, more then 80 artictles of the chosen 98 have been annotated for molecular function and process. Additionally, Dmitry is working to improve the usefulless of MGI internal GO QC reports.  
+
*Dmitry Sitnikov finishes up collaboration with Larry Hunter's group (Dr. Mike Bada) to establish a large, high-quality, corpora of full-text publications, expertly annotated with expressive knowledge representations, to improve the performance of a wide variety of biochemical text mining systems and to create new approaches to text mining. This involves systematically training and evaluating a broad sample of information extraction methods for key tasks, including concept and relationship identification. This effort can also be useful in synonym improvements to the GO between GO terms and certain biological concepts and terminology used in the literature. A total of 98 articles have been annotated for molecular function and process. Additionally, Dmitry is working to improve the usefulless of MGI internal GO QC reports.  
  
*As the designated coordinator of the MGI/GO project with the GO Reference Genome project,  Li Ni participates in annotations of genes assigned by the Reference Genome Project, maintain the mouse Reference Genome list on MGI GO wiki and Google spreadsheet, maintain the Reference Genome status table on GO wiki, oversees the curation of Reference Genome Genes for the mouse group.  
+
*As the designated coordinator of the MGI/GO project with the GO Reference Genome project,  Li Ni participates in annotations of genes assigned by the Reference Genome Project, maintain the mouse Reference Genome list on MGI GO wiki and Google spreadsheet, maintain the Reference Genome status table on GO wiki, oversees the curation of Reference Genome Genes for the mouse group. Li responds and resolves questions about MGI GO annotations for the reference genome annotation project genes, and especially responds and resolves questions from the lead PAINT curator (see Reference Genome Project report for a description of PAINT). 
  
*Mary Dolan has been involved in a collaboration with Carol Bult at MGI on aligning gene ontology annotations for mouse genes assigned to MouseCyc pathways. See
+
*Mary Dolan has been involved in a collaboration with Carol Bult at MGI on aligning gene ontology annotations for mouse genes assigned to MouseCyc pathways (See http://www.informatics.jax.org/pathways.shtml) and exploring computational methods for associating functional, pathway, and phenotypic data. Mary also provides various files for the Reference Genome Project, for example, a report to assess the GO annotation status of PANTHER families and subfamilies based on annotations for all reference genome organism genes in the groups.  
  
See http://www.informatics.jax.org/pathways.shtml
+
* Collaboration with BioGRID: We have just begun a collaboration with the BioGRID (Biological General Repository for Interaction Datasets) to add protein binding annotations (IPI evidence code), as well as annotations based on genetic interactions ((G()  curated for GO at MGI into BioGRID. The protein binding annotations are augmented in many cases by the use of the expanded evidence code ontology (ECO) to supply more detail as to the type of experiment used for the annotation. Harold has supplied supporting files to Rose Oughtred, Senior Scientific Curator for the Genome Databases Group at the Lewis-Sigler Institute for Integrative Genomics, Princeton for initial incorporation of these annotations.

Latest revision as of 12:44, 4 June 2014

Mouse Genome Informatics Summary, 2010

Overview

Staff:

Judith Blake*

Alexander Diehl*

Mary Dolan*

Harold J Drabkin*

Midori Harris*

David Hill*

Li Ni

Dmitry Sitnikov


  • Funded entirely or partially by GO

Annotation Progress

We continue to put emphasis on those genes selected for the Reference Genome Project. Additional emphasis has been placed on certain genes associated with lung development.


MGI GO STATS as of December, 2010


Annotation Type 01_Dec_10 09_Dec_09 Change % Change
Total Genes annotated (with at least one GO term of any kind):
33906*
18207
15699
86.23
Total Manual Annotation
Number of Genes
32670
11668
21002
180
Orthology:
8187
752
7435
988.7
IEA Annotation
SwissProt to GO
15690
16050
-360
-2.24
Interpro to GO
10530
10749
-219
-2.04
EC to GO
1033
1510
-447
-31.59
* 100% of current gene models


The large changes in manual (non-IEA) curated genes are the result of the addition of 5 efforts.

  1. Annotating genes with no literature annotation to one or more of the three roots. Quality control reports now alert curators for any genes annotated to one or more of the three roots when new literature is added to MGI and the literature is indexed to these genes.
  2. We have added a pipeline to create annotations inferred by sequence orthology (ISO) to mouse genes that have rat or human orthologs where the rat or human orthologs have been annotated by experiment.
  3. We have added a pipeline to load GOA annotations to mouse genes.
  4. We have added a pipeline to add annotations based on intra-ontology relationships.
  5. We have added a pipeline to add annotations by on sequence similarity (ISS)based on Panther family membership via the Reference Genome project.


Methods and strategies for annotation

Literature curation:

Literature curation continues to be the major focus of our annotation efforts. We continue to explore natural language processing tools to aid in identifying the genes in papers selected for GO.


Computational annotation strategies:

As always current strategies involve use of translation table to mine SwissProt keywords, InterPro domains, and EC numbers for IEA annotation. These are performed automatically on a nightly basis and require little human intervention.


Priorities for annotation

  1. Genes assigned by Reference Genome Project (everyone)
  2. Isoform curation (Harold, Protein Ontology project); now co-ordinating with 1 by focusing on reference genes that have isoforms.
  3. Genes with no GO annotation but with literature (Li and Dmitry)
  4. Genes with only IEA annotation but with literature (Li)
  5. Genes identified as being important in lung development (Dmitry)
  6. Genes marked as having GO annotation completed, but now having new literature (Dmitry)

Presentations and Publications


  • Publications

Gene Ontology Consortium. The Gene Ontology in 2010: extensions and refinements. Nucleic Acids Res. 2010 Jan;38(Database issue):D331-5. NAR

Hill DP, Berardini TZ, Howe DG, Van Auken KM. Representing ontogeny through ontology: a developmental biologist's guide to the gene ontology. Mol Reprod Dev 2010; 77(4):314-29.

Alterovitz G, Xiang M, Hill DP, Lomax J, Liu J, Cherkassky M, Dreyfuss J, Mungall C, Harris MA, Dolan ME, Blake JA, Ramoni MF. Ontology engineering.Nat Biotechnol. 2010 Feb;28(2):128-30.

  • Tutorials and Workshops
  • Posters

Drabkin HJ et al. (MGI), Title: "Proteins, Pathways, and Macromolecular Complexes"; ISMB (July 2010)

A. Ontology Development Contributions:

  • 1. David Hill has worked on a team with Tanya Berardini, Chris Mungall, Midori Harris and Jane Lomax to develop cross-products within and among the three GO namespaces.
  • 2. David Hill continues to work with Chris Mungall and Tanya Berardini to add inter-ontology links in GO.
  • 3. David Hill has worked with Yasmin Alam-Faruque, Doug Howe, Midori Harris, Susan Tweedie, Becky Foulger and community experts to expand the kidney development portion of GO.
  • 4. Alexander Diehl is project leader for the Cell Ontology (with Chris Mungall) and Terry Meehan is a full-time curator working on the Cell Ontology. Terry has finished implementing cross-products for hematopoietic cell ontology terms and is working on general improvements to the CL, and has moved on to import of FMA cell types, among others. Alex is focusing improvements to the representation of neurons in the CL, part of an ongoing collaboration with the International Neuroinformatics Framework (INCF). In May 2010 we held a very successful Cell Ontology Workshop at The Jackson Laboratory where many issues regarding the longterm development of the ontology were settled. We will hold another workshop on neurons in the first quarter of 2011. (See separate progress report for the Cell Ontology). In summer 2010 Alex mentored Morgan V. Hightshoe, a returned member of the Jackson Laboratory Summer Student Program, and Wade Valleau, a local high school intern in linked projects to revise the representation of nervous system cell types in the Cells Ontology. Wade received support from INCF for his work. Alex continues to act as the GOC liaison to the Infectious Disease Ontology and Vaccine Ontology groups and to act on term requests for the GO from those groups, and is active in the GO Signaling and Virus content development groups.
  • 5. David Hill and Jane Lomax oversee the biological content development of GO. In particular, all new developmental biology-related terms submitted to SourceForge are handled by David Hill.
  • 6. David Hill and Harold Drabkin have been working with Tanya Berardini, Chris Mungall, Midori Harris, Jane Lomax and ChEBI curators to align GO with ChEBI. This will result in the first set of cross-products with GO and an external ontology.
  • 7. David Hill and Karen Christie have been collaborating to revise and update the transcription area of GO.

Annotation Outreach and User Advocacy Efforts:

  • The Protein Ontology project continues to provide a web interface (http/pir.georgetown.edu/cgi-bin/pro/race_pro) whereby functional annotation using the GO can be applied to PRO submissions. These are reviewed by Cecilia Arighi of Georgetown. At present, only the PRO curators (Georgetown and MGI) are using the tool, but it is available to anyone.
  • Harold is mentoring two curators in Donna Slonim's group at Tufts, Heather Wick and Craig Fournier. They are focusing on genes involved in human fetal development.
  • David Hill continues to serve on the GO-help rota.

Other Highlights:

  • We are now suppling a GAF 2.0 format file to GOC with column 16 cell type and column 17 isoform data filled in. This file is also available directly from our own FTP site.
  • Dmitry Sitnikov finishes up collaboration with Larry Hunter's group (Dr. Mike Bada) to establish a large, high-quality, corpora of full-text publications, expertly annotated with expressive knowledge representations, to improve the performance of a wide variety of biochemical text mining systems and to create new approaches to text mining. This involves systematically training and evaluating a broad sample of information extraction methods for key tasks, including concept and relationship identification. This effort can also be useful in synonym improvements to the GO between GO terms and certain biological concepts and terminology used in the literature. A total of 98 articles have been annotated for molecular function and process. Additionally, Dmitry is working to improve the usefulless of MGI internal GO QC reports.
  • As the designated coordinator of the MGI/GO project with the GO Reference Genome project, Li Ni participates in annotations of genes assigned by the Reference Genome Project, maintain the mouse Reference Genome list on MGI GO wiki and Google spreadsheet, maintain the Reference Genome status table on GO wiki, oversees the curation of Reference Genome Genes for the mouse group. Li responds and resolves questions about MGI GO annotations for the reference genome annotation project genes, and especially responds and resolves questions from the lead PAINT curator (see Reference Genome Project report for a description of PAINT).
  • Mary Dolan has been involved in a collaboration with Carol Bult at MGI on aligning gene ontology annotations for mouse genes assigned to MouseCyc pathways (See http://www.informatics.jax.org/pathways.shtml) and exploring computational methods for associating functional, pathway, and phenotypic data. Mary also provides various files for the Reference Genome Project, for example, a report to assess the GO annotation status of PANTHER families and subfamilies based on annotations for all reference genome organism genes in the groups.
  • Collaboration with BioGRID: We have just begun a collaboration with the BioGRID (Biological General Repository for Interaction Datasets) to add protein binding annotations (IPI evidence code), as well as annotations based on genetic interactions ((G() curated for GO at MGI into BioGRID. The protein binding annotations are augmented in many cases by the use of the expanded evidence code ontology (ECO) to supply more detail as to the type of experiment used for the annotation. Harold has supplied supporting files to Rose Oughtred, Senior Scientific Curator for the Genome Databases Group at the Lewis-Sigler Institute for Integrative Genomics, Princeton for initial incorporation of these annotations.