MGI December 2013

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Overview:

Staff:

[please include FTEs working on GOC tasks designating as well how many FTEs funding by GOC NIHGRI grant]

Judith Blake*

Karen R Christie*

Mary E Dolan*

Harold J Drabkin*

David Hill*

Li Ni

Dmitry Sitnikov

* Funded entirely or partially by GO

Annotation Progress

Annotation Type Dec 5 2012 Dec 5 2013 Change % change
Total Genes annotated with at least one GO term of any kind 25452 25406 TBA TBA
Total Annotations: 286957 303195 TBA TBA
Total non-IEA Annotation
Total Number of Genes: 24550 24597 TBA TBA
Total Annotations: 193088 208808
Annotation by Direct Experiment
MGI Curated Genes 11104 11558
MGI Curated Anntations 70615 75497
GOA Curated Genes: 3475 4067
GOA Curated Annotations: 18055 21976
Annotation by Orthology
Total Genes Annotated by Orthology 9451 9826
Total Orthology Annotation 68621 74777
Genes Annotated by Human Orthology Load (GOA) 7756 8177
Total Annotation by Human Orthology Load 42237 46001
Genes Annotated by Rat Orthology Load (RGD) 4083 4160
Total Annotations by Rat Orthology Load 23323 24575
IEA Annotation
Total Genes with IEA Annotations 16372 16786
Total IEA Annotations 93869 9438
Total Genes with SwissProt to GO Annotations 15971 16415
Total SwissProt to GO Annotations 64733 65804
Total Genes with Interpro to GO Annotations 9792 10233
Total Interpro to GO Annotations 27804 27418
Total Genes with EC to GO Annotations 944 930
Total EC to GO Annotations 1332 1165

Methods and strategies for annotation

Literature curation:

Literature curation continues to be the major focus of our annotation efforts.

Computational annotation strategies:

As always, current strategies involve use of translation table to mine SwissProt keywords, InterPro domains, and EC numbers for IEA annotation. These are performed automatically on a nightly basis and require little human intervention.

Priorities for annotation

  • Isoform curation (Harold, Karen, Protein Ontology project); focusing on genes that have isoforms or whose products are modified, and co-ordinate with the Protein Ontology Protein Complex project.
  • Genes with no GO annotation but with literature (Li and Dmitry)
  • Genes with only IEA annotation but with literature (Li)
  • Genes marked as having GO annotation completed, but now having new literature (Dmitry)
  • Genes that have an annotation to one of the three root nodes of GO, but have new literature (David, Karen, Dmitry)
  • Dmitry has been focused on annotation or miRNAs in MGI

Presentations and Publications

a. Papers with substantial GO content

Hill DP, Adams N, Bada M, Batchelor C, Berardini TZ, Dietze H, Drabkin HJ, Ennis M, Foulger RE, Harris MA, Hastings J, Kale NS, de Matos P, Mungall CJ, Owen G, Roncaglia P, Steinbeck C, Turner S, Lomax J. Dovetailing biology and chemistry: integrating the Gene Ontology with the ChEBI chemical ontology. BMC Genomics. 2013 Jul 29;14:513. doi: 10.1186/1471-2164-14-513.

Roncaglia P, Martone ME, Hill DP, Berardini TZ, Foulger RE, Imam FT, Drabkin H, Mungall CJ, Lomax J. The Gene Ontology (GO) Cellular Component Ontology: integration with SAO (Subcellular Anatomy Ontology) and other recent developments. J Biomed Semantics. 2013 Oct 7;4(1):20. doi:10.1186/2041-1480-4-20. PubMed PMID: 24093723.


b. Presentations including Talks and Tutorials and Teaching

c. Poster presentations

Other Highlights:

A. Ontology Development Contributions:

  • 1. David Hill continues working with Tanya Berardini, Chris Mungall, Paola Roncaglia and Jane Lomax develop cross-products within and among the three GO namespaces.
  • 2 David Hill and Jane Lomax oversee the biological content development of GO. David now has a regular spot in the rotation to address GO Sourceforge items.
  • 4. David Hill has worked with the GO ontology development and software groups to develop a web-based tool for requesting new terms.

B. Annotation Outreach and User Advocacy Efforts:

  • The Protein Ontology project continues to provide a web interface (http/pir.georgetown.edu/cgi-bin/pro/race_pro) whereby functional annotation using the GO can be applied to PRO submissions.
  • Harold Drabkin continues to serve on the GO-help rota.
  • Judith Blake and Karen Christie are working with Rama Balakrishnan to coordinate with Astrid Laegrid of the Norwegian University of Science and Technology in Trondheim to determine how to incorporate GO annotations for transcription factors made by this group.


C. Other Highlights:

  • As the designated coordinator of the MGI/GO project with the GO Reference Genome project, Li Ni participates in annotations of genes assigned by the Reference Genome Project, oversees the curation of Reference Genome Genes for the mouse group. Li responds and resolves questions about MGI GO annotations for the reference genome annotation project genes, and especially responds and resolves questions from the lead PAINT curator (see Reference Genome Project report for a description of PAINT). Li is also part of the PAINT curation team.
  • Mary Dolan has begun working with other members of the GO software team on Galaxy for GO. In the past, most groups have used Galaxy for sequence analysis. The focus of the GO Galaxy initiative will be functional analysis, implementing GO tools in Galaxy. Mary also provides various files for the Reference Genome Project, for example, a report to assess the GO annotation status of PANTHER families and subfamilies based on annotations for all reference genome organism genes in the groups.