Agenda
Transferring annotations to geneproducts in between strains
Hi Rama,
I have a quick question for you regarding how your group manually maps curated GO annotations
from one bacterial strain to another of the same species.
I was wondering if the best practice would be to use the same evidence code (e.g. IDA) for
cases where I was looking at conservative ortholog calls for genes of the same species, different strains?
Or should I use the ISO code and the with_from value (e.g. PseudoCAP:PA1777) to indicate the strain the
function/process was observed in? I used the former approach when I originally did some GO mapping to
Pseudomonas aeruginosa strains in our database, but I'm now leaning toward the latter approach in order to
make the logic behind the call more transparent.
Do you have any opinion on which approach is best?
Thanks for any help you can offer!
Geoff