Minutes Heart Development workshop (Archived)

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genome biol 2008 Jan 9:9 (1):R6 ES cells differentiation into cardiac cells

Check terms are applicable across Bilateria

  • heart

Current GO description: The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

  • blood
  • vessels

Current GO description: The blood vessel is the vasculature carrying blood.

  • blood circulation

Current GO description: The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.

Not all invertebrates transport O2 through 'blood', Susan proposes to remove hemolymph because it is not used and just relax the definition of blood from blood circulation. Shomou: we need to consider the evolutionary relationship, and in this case there is an evolutionary relationship. Paul: some organisms this might not work for David: redifined blood within blood circulation Varsha: should we have child terms, eg O2 carrying and O2 not carried Susan: need to move onto open and closed circulatory system. Look at merging hemolymph circulation into blood circulation. David: Merge hemolymph circulation into blood circulation and hemolymph circulation as a narrow synonym. Susan: Cardiogenesis needs to be synonym of heart formation. David: make Cardiogenesis a related synonym.

Cardiac precursor tissues and cells

Development of primary and secondary heart fields cardiac muscle cell specification/differentiation/development cardiac endothelial cell specification/differentiation/development


Cardiac cell migration, Heart morphogenesis


* morphogenic and migratory changes to those cell populations as they move towards formation of the heart tube
* L/R patterning
* neural crest contribution to the heart
* SF - cell migration, heart tube, heart looping and jogging | |-valign="top" |12:30pm |Lunch at Ask on Grafton Way. Menu | |-valign="top" |2pm |Continue with Cardiac cell migration, Heart morphogenesis | |-valign="top" |2:45pm |Heart structure formation
* heart chamber, septum, trabeculae, valves
* SF - heart hypertrophy, septum morphogenesis, chamber development, heart valves | |-valign="top" |3:45pm |Coffee break | |-valign="top" |4pm |Cardiac conduction
* development of the electrical signaling systems of the heart
* SF - cardiac conduction | |-valign="top" |5pm |Close | |}