Minutes Heart Development workshop (Archived)

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genome biol 2008 Jan 9:9 (1):R6 ES cells differentiation into cardiac cells

Check terms are applicable across Bilateria

  • heart

Current GO description: The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

  • blood
  • vessels

Current GO description: The blood vessel is the vasculature carrying blood.

  • blood circulation

Current GO description: The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.

Not all invertebrates transport O2 through 'blood', Susan proposes to remove hemolymph because it is not used and just relax the definition of blood from blood circulation.
Shomou: we need to consider the evolutionary relationship, and in this case there is an evolutionary relationship.
Paul: some organisms this might not work for
David: redifined blood within blood circulation
Varsha: should we have child terms, eg O2 carrying and O2 not carried
Susan: need to move onto open and closed circulatory system. Look at merging hemolymph circulation into blood circulation.
David: Merge hemolymph circulation into blood circulation and hemolymph circulation as a narrow synonym.
Susan: Cardiogenesis needs to be synonym of heart formation.
David: make Cardiogenesis a related synonym.

Cardiac precursor tissues and cells

Development of primary and secondary heart fields
cardiac muscle cell specification/differentiation/development
cardiac endothelial cell specification/differentiation/development

Determination of left/right symmetry
David: Are you actively creating asymmetry or breaking symmetry.
Shoumo: Breaking symmetry
Doug: the gene would determine symmetry in an asymmetrical situation.
Shoumo: radial symmetry, sea urchin.
Doug: Consider change to asymmetry
David: Keep determination of left/right symmetry
Shomou: Adding part_of child terms, detection of nodal flow (created by cilium).

Heart Field Specification
Paul: is there one, two or three fields, this is controversial area? Depends whether this is based on lineage, expansion.
David: Keep general, and describe what is known within child terms, but keep controversial issues out of GO. In different organisms presence of 2 heart fields is accepted. therefore can have this terms but the annotators will not use them in organisms where descriptions are more controversial.
Shomou: what do we mean by heart field?
David: Definition: The region of the lateral plate mesoderm is delineated into the area in which the heart will develop.

Heart induction
David: Definition: positive regulation heart field specification
Agreed on signaling pathways involved in heart field specification: BMP signaling, FGF signaling, WNT canonical and WNT non-canonical signaling.
Shomou: BMP is from endoderm, signals to mesoderm
Paul: FGF from mesoderm,
David: Endoderm/mesoderm involved in heart field specification (induction)
Add parent: Mesodermal-endodermal cell signaling
Add child terms: BMP signaling
David: Ideally Signaling through SMADs should be a child of BMP signaling, to be developed through signaling working group.
Paul: FGF derived from mesoderm and endoderm.
David: create FGF and WNT signaling child terms
Discussion on Notch signaling
Peter: retinoid signaling, more involved in patterning than induction

Paul/Peter: Secondary and primary heart field child terms of heart field specification
Paul: Anterior heart field narrow synonym of Secondary heart field
Paul: Primary heart field specifications: bilateral field of cells mostly fated to form the primary heart field left ventricle.
Paul: Secondary heart field specification: will primarily form the right ventricle (Arterial pole and venous pole).
Paul: second heart field needed as exact synonym
Shomou: Left right patterning in lateral mesoderm, needs to be included in the field specification
Paul: Additional of TGFbeta signaling pathways to this branch and to detection of nodal flow

Cardiac cell migration, Heart morphogenesis


* morphogenic and migratory changes to those cell populations as they move towards formation of the heart tube
* L/R patterning
* neural crest contribution to the heart
* SF - cell migration, heart tube, heart looping and jogging | |-valign="top" |12:30pm |Lunch at Ask on Grafton Way. Menu | |-valign="top" |2pm |Continue with Cardiac cell migration, Heart morphogenesis | |-valign="top" |2:45pm |Heart structure formation
* heart chamber, septum, trabeculae, valves
* SF - heart hypertrophy, septum morphogenesis, chamber development, heart valves | |-valign="top" |3:45pm |Coffee break | |-valign="top" |4pm |Cardiac conduction
* development of the electrical signaling systems of the heart
* SF - cardiac conduction | |-valign="top" |5pm |Close | |}