Neurobiology Project
Summary
To expand and improve the GO biological processes terms and annotations for neurological processes including the core cellular processes for synaptic transmission, through to some of the higher order brain processes like cognition, and to fully augment GO cc with those terms in Neurological Information Framework (NIF)
Personnel
GO
Paola
External experts
- Dr. John Chua (GWDG) - main contact
- Dr. Mario Albrecht (Max Planck Institute)
Main interest is in biological processes concerning the synapse, particularly the presynaptic active zone (human). See their recent review below for examples of genes and processes.
The architecture of an excitatory synapse. Chua JJ, Kindler S, Boyken J, Jahn R. J Cell Sci. 2010 Mar 15;123(Pt 6):819-23. Review. PMID:20200227
- Maryann Martone (NIF, University of California)
- Neurological cell components
Timeline
- Preliminary phone conference
- Collect SF items
- First draft of new terms
- Ontology content meeting with experts
- Second draft of new terms
- Implementation of new terms
- Annotations to new terms
SF items
- New cc terms from NIFSTD - subcellular
- More new cc terms from NIFSTD - other
- Synaptic membrane
- Dendritic spine maintenance
- General term for amyloid formation
- Beta-amyloid formation
- Dorsal interneuron caudal and rostral axon projection
- Lateral motor column neuron migration
- Regulation of synaptic vesicles clustering
- Positive regulation of synaptic vesicles clustering
- Negative regulation of synaptic vesicles clustering
- Request GO terms for synapse assembly
- Is an apical dendrite a part of apical part of cell?