View source for Noctua Manual: Linking Activities in Form

*GO-CAMs aim to provide a causal representation of biological pathways and processes.  To accomplish this, curators can link Molecular Functions to one another using causal relations from the Relations Ontology.

*In the Form Editor, add one or more Molecular Function annotations according to [http://wiki.geneontology.org/index.php/Noctua_Form_Molecular_Function Creating a Molecular Function Annotation]

*As you create MF annotations, they will be added, alphabetically, to the annotation table on the right-hand side of the form.

*To link two activities, click on the 'Connect' icon to the right of the 'upstream' activity.

*From the remaining list of activities, select the 'downstream' activity by clicking on the 'Select' icon to the right of the activities.

*Step through the decision tree in the resulting causal relations editor as follows:

**Is the effect of the upstream activity on the downstream activity positive, negative, or unknown/neutral?
**Are the activities consecutive, i.e. does the upstream activity act directly on the downstream activity?
**Is there an intervening, 'activity-regulating' process between the upstream and downstream activities, and if so, what is it?


Back to [http://wiki.geneontology.org/index.php/Noctua#Noctua_Users_Manual Noctua Users Manual]


[[Category: Annotation]]