Non 1:1 receptor:ligand binding: Difference between revisions

From GO Wiki
Jump to navigation Jump to search
No edit summary
Line 4: Line 4:




For the problems and proposed solutions to the issue of non 1:1 receptor:ligand binding, see slides 22-25 of the [http://wiki.geneontology.org/images/6/62/Signaling_LA_May2011.pdf overview] from the LA GOC meeting, May 2011.
It's well known that there is cross-talk amongst ligands and receptors, particularly within the growth factors. To represent this in GO, we will most likely require terms for:
 
* ligand-activated signaling pathways (E.g. VEGF-activated signaling pathway)
* receptor signaling pathways (E.g. PDGF receptor signaling pathway: MOST EXISTING TERMS ARE IN THIS FORMAT)
* Combination terms (E.g. VEGF-activated PDGF receptor signaling pathway)
 
For more detail, see slides 22-25 of the [http://wiki.geneontology.org/images/6/62/Signaling_LA_May2011.pdf overview] from the LA GOC meeting, May 2011.
 
The main issue is that in function the activity of the PDGFR is to bind PDGF and transmit a signal. To represent cross-talk. PDGFR signaling (in process) would refer to the gene product called PDGF, which can be activated by multiple ligands (including non-PDGFs). To make this less-confusing (as agreed in the May 2011 GOC meeting), I've changed the function terms for the growth factor receptors from 'platelet-derived growth factor receptor activity' to 'platelet-derived growth factor-ACTIVATED receptor activity'. With the addition of a HAS_PART link to 'PDGF binding', the activity is restricted to signaling from PDGF.




Line 11: Line 19:
* Hormone and hormone receptor signaling pathways: https://sourceforge.net/tracker/?func=detail&aid=2974691&group_id=36855&atid=440764
* Hormone and hormone receptor signaling pathways: https://sourceforge.net/tracker/?func=detail&aid=2974691&group_id=36855&atid=440764
* Norrin signaling: https://sourceforge.net/tracker/?func=detail&aid=3041964&group_id=36855&atid=440764
* Norrin signaling: https://sourceforge.net/tracker/?func=detail&aid=3041964&group_id=36855&atid=440764
==Related Articles==
* VEGF can signal through platelet-derived growth factor receptors: PMID 17470632
* PDGF signaling in cells and mice. Figure 1 shows the preference of various PDGF members for PDGFRs: PMID 15207812

Revision as of 09:23, 2 November 2011

Return to GOC Main Page

Return to Signaling Main Page [[1]]


It's well known that there is cross-talk amongst ligands and receptors, particularly within the growth factors. To represent this in GO, we will most likely require terms for:

  • ligand-activated signaling pathways (E.g. VEGF-activated signaling pathway)
  • receptor signaling pathways (E.g. PDGF receptor signaling pathway: MOST EXISTING TERMS ARE IN THIS FORMAT)
  • Combination terms (E.g. VEGF-activated PDGF receptor signaling pathway)

For more detail, see slides 22-25 of the overview from the LA GOC meeting, May 2011.

The main issue is that in function the activity of the PDGFR is to bind PDGF and transmit a signal. To represent cross-talk. PDGFR signaling (in process) would refer to the gene product called PDGF, which can be activated by multiple ligands (including non-PDGFs). To make this less-confusing (as agreed in the May 2011 GOC meeting), I've changed the function terms for the growth factor receptors from 'platelet-derived growth factor receptor activity' to 'platelet-derived growth factor-ACTIVATED receptor activity'. With the addition of a HAS_PART link to 'PDGF binding', the activity is restricted to signaling from PDGF.


Related SourceForge Items


Related Articles

  • VEGF can signal through platelet-derived growth factor receptors: PMID 17470632
  • PDGF signaling in cells and mice. Figure 1 shows the preference of various PDGF members for PDGFRs: PMID 15207812
Retrieved from "https://wiki.geneontology.org/index.php?title=Non_1:1_receptor:ligand_binding&oldid=37911"