Ontology Development: Difference between revisions

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= Group's focus =
This group's purpose is to ensure that the Gene Ontology represents biology in a way that is useful for gene product annotation of reference genomes  and other MODs using the GO for annotation. The group serves as the link between biological knowledge that is gained from wet-bench scientists and the representation of that knowledge in the GO. Members of the group are responsible for reporting areas of the GO that need development and for suggesting changes and additions  to the GO as needs arise. Members of the group serve as biological experts in domains that are covered by their organism. They are responsible for reviewing changes to be sure that they accurately reflect our current understanding of biology.
This group's purpose is to ensure that the Gene Ontology represents biology in a way that is useful for gene product annotation of reference genomes  and other MODs using the GO for annotation. The group serves as the link between biological knowledge that is gained from wet-bench scientists and the representation of that knowledge in the GO. Members of the group are responsible for reporting areas of the GO that need development and for suggesting changes and additions  to the GO as needs arise. Members of the group serve as biological experts in domains that are covered by their organism. They are responsible for reviewing changes to be sure that they accurately reflect our current understanding of biology.
With the help of the software team the group create rules to ensure the ontology's integrity.


==Content Development ==
Pascale Gaudet (GOC); GitHub: @pgaudet
===Priority ranking===
 
====High Priority====
=Communication=
*Cross-products - see [[:Category:Cross_Products]] and [[Cross_Product_Guide]]
==Editor's Conference calls==
**[[Cell cross-products]] (Jane, Paola, Alex, Chris)
 
**[[XP:biological_process_xp_chebi |Chebi cross-products]] (David, Jane, Tanya, Chris, Harold, Paola, Becky)
=== When ===
*[[Function-Process Links]]
 
*[[Chemical terms in GO]](Part of the CHEbi alignment process)
* Calls are held weekly on Mondays, 12:00PM-1:00PM EST
*[[Transcription |Transcription & transcription factor activity overhaul]] (Karen, David)
* Calls are scheduled on the GO's Google calendar.  Please request access to the calendar if you don't have it.
*[[Virus terms|Virus-related term overhaul]] (Michelle Gwinn Giglio, Jane Lomax, Candace Collmer, Ariane Toussaint, Brenley McIntosh, Alexander Diehl & others)
* Reminder emails are sent out to the go-ontology mailing list (see [[Internal_email_lists]] to register).
*[[Apoptosis]] (Emily, Becky, Paola, Pablo and community experts)
 
 
=== Agenda and Minutes ===
* [[Ontology editors' conference call minutes 2020|2020]]
* Past Annotation Calls: [[Ontology Development reports 2005-2010|2005-2010]] |  [[Ontology editor's conference call minutes 2011|2011]] | [[Ontology editor's conference call minutes 2012|2012]] | [[Ontology editor's conference call minutes 2013|2013]] | [[Ontology editor's conference call minutes 2014|2014]] |  [[Ontology editor's conference call minutes 2015|2015]] | [[Ontology editor's conference call minutes 2016|2016]] | [[Ontology editor's conference call minutes 2017|2017]] | [[Ontology editor's conference call minutes 2018|2018]] | [[Ontology editors' conference call minutes 2019|2019]] |
 
= Documentation=
==[[Protege5_5_setup_for_GO_Eds|Protégé 5.5 setup]]==
==[[Installing and Using git]]==
==[[Ontology Editors Daily Workflow]]==
==Editing the Ontology==
 
 
{| class="wikitable"
!colspan="2" | [[General Gene Ontology Principles]]
|-
!colspan="2" | New terms
|-
|rowspan="10"|[[Principles for creating a GO term]] (being reviewed)
|[[Guidelines for creating a GO term]]
|-
|[[Guidelines for creating relationships between terms]] (being reviewed)
|-
|[[Guidelines for creating disjoint terms]] (to be written)
|-
|[[Guidelines for creating a Regulation Term]]
|-
|[[Guidelines for GO textual definitions]] (being reviewed)
|-
|[[Guidelines for equivalence axioms]]  (being reviewed) ---  Also [[Logical_Definitions]] (being reviewed)
|-
|[[Guidelines for new Molecular Functions]] (new)
|-
|[[Guidelines for new Biological Processes]] (new)
|-
|[[Guidelines for new Cellular Components]] (new)
|-
|[[Guidelines for 'database cross references' and 'definition database cross references']] (new)
|-
!colspan="2" |Modifying existing terms
|-
|rowspan="5"|[[Principles for Modifying an Existing Ontology Term]] (to be reviewed)
|[[Deleting Asserted Subclasses]]
|-
|[[Adding Term Comments]]
|-
|[[Adding a Term to a GO Subset (Slim)]]
|-
|[[Adding Taxon Restrictions| Adding and Removing Taxon Restrictions]]
|-
|[[Adding References to GitHub tickets]]
|-
!colspan="2" |Term obsoletion
|-
|rowspan="2" |[[Principles for term obsoletion]]
|[[Obsoleting an Existing Ontology Term]]
|-
|[[Restoring an Obsolete Ontology Term]]
|-
!colspan="2" |Term merges
|-
|[[Principles for merging terms]] (being reviewed)
|[[Merging Ontology Terms]]
|-
!colspan="2" |Subsets
|-
|Subset documentation (to add)
|[[Adding and Removing GO Subsets (Slims)]]
|-
!colspan="2" |Import Files
|-
| Principles for [[GO import files]]
|[[Adding Terms and Regenerating the Import Files]]
|}
 
==[[Relations]] General Relations Documentation Draft To be reviewed==
 
==Website - to be moved to the wiki?==
 
* [http://www.geneontology.org/page/biological-process-ontology-guidelines  Biological-process-ontology-guidelines]


====Medium Priority====
=[[Identifiers]] To be reviewed=
*[[Non-symbiotic multi-organism processes]] (Jane)
*[[Neurobiology Project]] (David, Tanya, Jane, Paola)
*[[:Category:Content MENGO|MENGO collaboration]] (Jane)
*[[Signaling |Signaling overhaul]] (Becky, signaling WG)
*[[Kidney Physiology]] (David, Yasmin, Doug, Tanya, Becky, Edinburgh GUDMAP group)
*[[Cardiac conduction]] (David, Ruth, Doug, Tanya, Becky, Paola, Stan)
*[[Neuro Behaviour Ontology (NBO)-GO alignment]] (Jane, George Gkoutos, Chris)
*[[Cell Cycle]] (Val, Pombe experts, GOEds)


====Low priority====
=[[Content Meeting Documentation|Guidance for organizing content meetings]]=
*Peripheral nervous system development
(old doc, but basic principles still apply)
*[[Uberon alignment]]


===Timeline===


[[2010 Timeline]]
=Content Development =
==Ongoing Projects==
*[[Transcription 2018]] (Pascale, Ruth, Astrid, Marcio, Paul T)
*[[Cell Cycle]] (Val, Pombe experts, GOEds)
*[[Enzymes and EC mappings]]
*[[Non-symbiotic multi-organism processes]] (Jane, David OS)
* Signaling: [[2017 Cambridge GOC Signalling Workshop]]
* [[Protein_Complexes:_who,_what,_where]]


[[2011 Timeline]]
===Low priority===
*[[Neuro Behaviour Ontology (NBO)-GO alignment]] (Jane, George Gkoutos, Chris, DavidOS)
*[[microbial ontology development and annotation]]


[[2012 Timeline]]
===Completed projects===
*[[Adding missing CHEBI xps]]
*[[Cell cross-products]], [[Cell-type specific GO terms]] (Jane, Paola, Alex, Chris, DavidOS)
*Addition of cross-products - see [[:Category:Cross_Products]] and [[Cross_Product_Guide]]
*[http://wiki.geneontology.org/index.php/Extensions/x-metazoan-anatomy Uberon alignment] (DavidH)
*[[:Category:Content MENGO|MENGO collaboration]] (Jane)
*[[:Category:Content PAMGO|PAMGO collaboration]] (Jane)
*[[:Category:Content PAMGO|PAMGO collaboration]], phase 1
*[[:Category:Content PAMGO|PAMGO collaboration]], phase 2 (as of Jan. 2007)
*[[Apoptosis]] (Emily, Becky, Paola, Pablo and community experts) - Feb 2013
*[[Autophagy 2015-2016]] (Paul D, Marc F, David H, Ruth, Paola and community experts) - [https://www.ncbi.nlm.nih.gov/pubmed/29455577 Denny et al 2018]
*[[ASCB 2009]]
*[[Binding_terms_working_group|Binding]] discussion - mainly annotation issues, but with some ontology content points
*[[Cardiac conduction]] (David, Ruth, Doug, Tanya, Becky, Paola, Stan)
*[[Cardiovascular physiology/development]] - implemented Oct 2007
*[[Cellular component processes]] (Jane, David, Midori, Val, ad hoc others) - started summer 2008
*[[Central Nervous System Development]]
*[[Chaperones]](completed by working group at Cambridge GOC meeting Sept. 2009)
*Ciliary components and processes (Paola, Karen Christie, SYSCILIA experts) [https://www.ncbi.nlm.nih.gov/pubmed/29177046 Roncaglia et al 2017]
*[[Collaboration with MIT GO-Engineering]] - Manuscript written
*[[Electron transport]]
*Extracellular RNA-containing vesicles (Paola, Aleks and community experts) [https://www.ncbi.nlm.nih.gov/pubmed/27076901 Cheung et al 2016]
*[[FP-regulates| regulates links between function and process]] (David, Tanya)
*Gene expression ([https://sourceforge.net/tracker/?func=detail&atid=440764&aid=1418820&group_id=36855| SF 1418820])
*[[Function-Process Links]]
*[[Heart_Development_workshop|Heart Development]] (David, Ruth, Varsha, Doug, Susan, Yasmin, Becky)
*[[Lung_Development]] (David, Jen, community experts)
*[[Immunology Revisions]]
*[[Isa-complete_BP|is_a complete biological process]]
*[[Kidney Development]] (David, Yasmin, Doug, Tanya, Becky, Edinburgh GUDMAP group)
*[[Kidney Physiology]] (David, Yasmin, Doug, Tanya, Becky, Edinburgh GUDMAP group)
*[[Morphogenesis]] (David, Tanya)
*[[Muscle Biology]] - Started Feb. 2007; meeting July 2007; Done Oct 2007
*[[Neurobiology Project]] (David, Tanya, Jane, Paola, DavidOS)
*[[Plant_term]] - March 28, 2007
*[[plasma lipoprotein particle ontology]] - done Sept. 2010
*[[Proteases |Peptidase & protease activity overhaul]] begun June 2008; essentially completed August 2008
*[[Regulation Main Page]] live March 2008
*[[Regulators |Regulator, activator and inhibitor MF terms]] (David, Tanya)
*[[RNA processing]]
*[[SDB 2009]]
*[[Sensu Main Page|Sensu revamp]]
*[[Signaling |Signaling overhaul]] (Becky, signaling WG)
*[https://github.com/geneontology/synapse Synapse project] (Synapse experts, DavidOS, Becky Foulger) - completed 2018
*[[Transcription |Transcription & transcription factor activity overhaul]] (Karen, David) - 2012
*[[Transporters]] (Jen and community experts) - Started Feb. 2007
*[[Utilization]] - done March 2010
*[[Virus terms|Virus-related term overhaul]], [[Virus_ontology_devt_July_2012|Phage Terms]] (Jane Lomax, Brenley McIntosh, Rebecca Foulger & others)
*Generic [[GO slim overhaul]] (Jane & Val)
*Make cc part_of tree complete (i.e. find homes for the children of 'unlocalized protein complex')
*regulates links- Dec 2008 (David, Tanya)
*Correct disjointness violations
*Rework disjoint terms as [http://gocwiki.geneontology.org/index.php/Are_multi-organism_process_and_cellular_process_disjoint%3F#Conclusion concluded in discussion on GO list] (Jane).


===Proposed content work===
===Proposed content work===
A list of topics that  we propose to address, but for which a timeline has not been set
A list of topics that  we propose to address, but for which a timeline has not been set


*Revamp embryonic and post-embryonic terms to be logically defined with cross products to stage ontology.
*Rework disjoint terms as [http://gocwiki.geneontology.org/index.php/Are_multi-organism_process_and_cellular_process_disjoint%3F#Conclusion concluded in discussion on GO list].
*Overhaul [[translation]], similar to what's being done for transcription. [https://sourceforge.net/tracker/?func=detail&atid=440764&aid=1891512&group_id=36855| SF 1891512] is closed, but notes some issues for consideration. (midori 2010-10-04)
* [[Recombination and DNA repair]]
* [[RNA processes]]
* [[Bile formation and secretion processes]]
* [[multi-organism processes v/s cellular processes]]
* [[protein and peptidyl amino acid modification / protein processing]]
* [[protein and peptidyl amino acid modification / protein processing]]
* [[Response to drug]]
* [[Response to drug]]
* [[Polyketide synthases]]
* [[Polyketide synthases]]
* [[cell growth/proliferation/division]]
* [[oxidoreductases]]


===[[Completed ontology content work]]===
=Quality Control=
==SPARQL checks on the ontology==
[https://github.com/rctauber/robot/tree/reporting/robot-core/src/main/resources/queries SPARQL checks on the ontology]


==Other Ontology Development Group Activities==
==Ontology release pipeline==
* [[Release Pipeline]]
* [http://current.geneontology.org/reports/gorule-report.html GO Rules rrrors reports]
 
'''TO BE REPLACED'''
*Ongoing work on Quality control reports; see [[Ontology_Quality_Control]] (David, Jane, Chris, Tanya)
*Ongoing work on Quality control reports; see [[Ontology_Quality_Control]] (David, Jane, Chris, Tanya)
*[[Tracker wishlist]]
*[[Content Meeting Documentation]]
**[http://wiki.geneontology.org/index.php/Content_Meeting_Participants_Information|Content meeting participants' information]
*[[:Category:Curator Guides|Curator guides]]
*[[Ontology Documentation Drafts]] - for working on documentation of ontology content that will become part of the web-based documentation
*[[microbial ontology development and annotation]]
*[[New Ontology Editor Training]]
*[[Cell-type specific GO terms]]
*[[Ontology_Development_Reports|Reports]]
*[[Ontology Editing Examples]]
*[[Protege workshop]]
*[[TermGenie1 Gatekeeper Rota]]
*[[Template-able Requests Prior To TG]]
*[[Regulation]]
*[[Jenkins]]
==Editor's Conference calls-weekly 9-9:30 AM PST==
*[[Ontology editor's conference call minutes 2011|2011 minutes]]
*[[Ontology meeting 2012-01-04|Jan 4]]
*[[Ontology meeting 2012-01-11|Jan 11]]
*[[Ontology meeting 2012-01-18|Jan 18]]
*[[Ontology meeting 2012-01-25|Jan 25]]
*[[Ontology meeting 2012-02-01|Feb 1]]
*[[Ontology meeting 2012-02-08|Feb 8]]
*[[Ontology meeting 2012-02-15|Feb 15]]
*[[Ontology meeting 2012-02-22|Feb 22]]
*[[Ontology meeting 2012-02-29|Feb 29]]
*[[Ontology meeting 2012-03-07|Mar 7]]
*[[Ontology meeting 2012-03-14|Mar 14]]
*[[Ontology meeting 2012-03-21|Mar 21]]
*[[Ontology meeting 2012-03-28|Mar 28]]
*[[Ontology meeting 2012-04-04|Apr 4]]
*[[Ontology meeting 2012-04-11|Apr 11]]
*[[Ontology meeting 2012-04-18|Apr 18]]
*[[Ontology meeting 2012-04-25|Apr 25]]
*[[Ontology meeting 2012-05-02|May 2]]
*[[Ontology meeting 2012-05-09|May 9]]
*[[Ontology meeting 2012-05-16|May 16]]
*[[Ontology meeting 2012-05-23|May 23]]
*[[Ontology meeting 2012-05-30|May 30]]




==Administrative==
*[[Ontology Development group summary]]
*[[Meeting_minutes:_general_topics|Miscellaneous meeting minutes]]


[[Category:Ontology]]
[[Category:Ontology]][[Category:GO Editors]]

Revision as of 02:37, 22 June 2020

Group's focus

This group's purpose is to ensure that the Gene Ontology represents biology in a way that is useful for gene product annotation of reference genomes and other MODs using the GO for annotation. The group serves as the link between biological knowledge that is gained from wet-bench scientists and the representation of that knowledge in the GO. Members of the group are responsible for reporting areas of the GO that need development and for suggesting changes and additions to the GO as needs arise. Members of the group serve as biological experts in domains that are covered by their organism. They are responsible for reviewing changes to be sure that they accurately reflect our current understanding of biology. With the help of the software team the group create rules to ensure the ontology's integrity.

Pascale Gaudet (GOC); GitHub: @pgaudet

Communication

Editor's Conference calls

When

  • Calls are held weekly on Mondays, 12:00PM-1:00PM EST
  • Calls are scheduled on the GO's Google calendar. Please request access to the calendar if you don't have it.
  • Reminder emails are sent out to the go-ontology mailing list (see Internal_email_lists to register).


Agenda and Minutes

Documentation

Protégé 5.5 setup

Installing and Using git

Ontology Editors Daily Workflow

Editing the Ontology

General Gene Ontology Principles
New terms
Principles for creating a GO term (being reviewed) Guidelines for creating a GO term
Guidelines for creating relationships between terms (being reviewed)
Guidelines for creating disjoint terms (to be written)
Guidelines for creating a Regulation Term
Guidelines for GO textual definitions (being reviewed)
Guidelines for equivalence axioms (being reviewed) --- Also Logical_Definitions (being reviewed)
Guidelines for new Molecular Functions (new)
Guidelines for new Biological Processes (new)
Guidelines for new Cellular Components (new)
Guidelines for 'database cross references' and 'definition database cross references' (new)
Modifying existing terms
Principles for Modifying an Existing Ontology Term (to be reviewed) Deleting Asserted Subclasses
Adding Term Comments
Adding a Term to a GO Subset (Slim)
Adding and Removing Taxon Restrictions
Adding References to GitHub tickets
Term obsoletion
Principles for term obsoletion Obsoleting an Existing Ontology Term
Restoring an Obsolete Ontology Term
Term merges
Principles for merging terms (being reviewed) Merging Ontology Terms
Subsets
Subset documentation (to add) Adding and Removing GO Subsets (Slims)
Import Files
Principles for GO import files Adding Terms and Regenerating the Import Files

Relations General Relations Documentation Draft To be reviewed

Website - to be moved to the wiki?

Identifiers To be reviewed

Guidance for organizing content meetings

(old doc, but basic principles still apply)


Content Development

Ongoing Projects

Low priority

Completed projects

Proposed content work

A list of topics that we propose to address, but for which a timeline has not been set

Quality Control

SPARQL checks on the ontology

SPARQL checks on the ontology

Ontology release pipeline

TO BE REPLACED