Ontology meeting 2012-08-22

45-minute meeting

MINUTES: Tanya

ATTENDEES:

Multi-functional enzymes

For example, terminase has two functions: translocating the nucleic acid into the phage head, and cleaving it at the correct point. These are always coupled.

We get these issues in SF all the time, so we need to come up with a general solution, even if it's not likely to be our final solution.

A related issue is where the same or similar reactions can be carried out by one enzyme v/s multiple enzymes. We've handled this inconsistently in the ontologies - sometimes we have one term for the overall reaction (especially where EC do this e.g. methylthiol:coenzyme M methyltransferase activity ; GO:0044683), sometimes we break it into its constituent parts.