Ontology meeting 2021-08-16
- Group members: Pascale, Karen, Harold, Raymond, Peter, Jim, Tanya, Kimberly, David, Chris, Paul
- Present:
- Regrets:
Agenda
Documentation
- Review cross-reference documentation: http://wiki.geneontology.org/index.php/Guidelines_for_%27database_cross_references%27_and_%27definition_database_cross_references%27
- Review protein binding term documentation http://wiki.geneontology.org/index.php/Guidelines_for_new_Binding_terms
- NAD/NADP: do we keep a grouping term even if all annotations can be classified to NAD or NADP-dependent? for eg GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P) activity]
IDPO terms
https://docs.google.com/spreadsheets/d/1IKKC9uShylCtf_lcBs6miI8PoqVL3L9S0rR6hz1mXxc/edit#gid=0
Outstanding:
- self-inhibitor: Protein interactions in cis that auto-inhibit the protein function. Source: PMID: 27135163
- self-activator: Protein interactions in cis that auto-activate the protein function. Source: PMID: 27135163
- liquid-liquid phase separation: Reversible process by which a solution of biopolymers separates into two coexisting phases: a condensate phase with liquid-like properties, and a dilute phase. Source: PMID:29602697 https://europepmc.org/abstract/MED/26455390
- entropic chain: Functions directly associated with the disordered state of proteins that stems from their ability to shift between conformational states without becoming structured. Includes entropic bristles, clocks and springs. Source: PMID:24773235 https://europepmc.org/abstract/MED/10585425
- flexible linker/spacer: Unstructured region connecting, providing separation and permitting movement between adjacent functional regions, e.g. structured domains or disordered motifs.Source: PMID:24773235 https://europepmc.org/abstract/MED/29739942