PTHR10218

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This is a list of questions that arose while PAINTing PTHR10218.

Questions for ontology curators

Cellular Component

  • Question: Should GO:0005834 "heterotrimeric G-protein complex" be moved down one level, from being a child of GO:0019897 "extrinsic to plasma membrane" to being a child of GO:0031234 "extrinsic to internal side of plasma membrane"? (SF # 3220764)
    • Curator comment: I'd say yes, the G protein complex interacts with the cytpoplasmic loops and cytoplasmic end of the transmembrane bundle, never the extracellular loops, so it is more accurate to use the suggested term.
    • Result: term moved as suggested.

Biological Process

  • Question: Is the term GO:0031684 "heterotrimeric G-protein complex cycle," defined as "The series of molecular events that generate a signal through the activation of G-protein subunits and recycling of these subunits," intended to refer to the G protein complexes that are cycled or to any external proteins that help them get cycled?
    • Curator answer: Insert answer here.