PTHR10373: Difference between revisions
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===Human LEF1=== | ===Human LEF1=== | ||
*'''Question: '''Is the IMP to GO:0043027 "caspase inhibitor activity" in PMID 20360943 appropriate? Does the experiment really show a biochemical interaction between LEF1 and caspase, or is reduction of caspase activity aresult of mutating LEF1? If the latter, shouldn't that be a BP annotation? | *'''Question: '''Is the IMP to GO:0043027 "caspase inhibitor activity" in PMID 20360943 appropriate? Does the experiment really show a biochemical interaction between LEF1 and caspase, or is reduction of caspase activity aresult of mutating LEF1? If the latter, shouldn't that be a BP annotation? | ||
**'''Curator answer: '''Insert answer here. | |||
*'''Question: '''Does LEF1 really bind estrogen, as the GO:0030284 "estrogen receptor activity" IDA from PMID 18794125 implies? How could LEF1 have both "estrogen receptor activity" and "estrogen receptor binding" activity (from the same paper)? | |||
**'''Curator answer: '''Insert answer here. | **'''Curator answer: '''Insert answer here. | ||
Revision as of 16:35, 4 August 2011
This is a list of questions that arose while PAINTing PTHR_____.
Questions for MOD curators
Molecular Function
Human LEF1
- Question: Is the IMP to GO:0043027 "caspase inhibitor activity" in PMID 20360943 appropriate? Does the experiment really show a biochemical interaction between LEF1 and caspase, or is reduction of caspase activity aresult of mutating LEF1? If the latter, shouldn't that be a BP annotation?
- Curator answer: Insert answer here.
- Question: Does LEF1 really bind estrogen, as the GO:0030284 "estrogen receptor activity" IDA from PMID 18794125 implies? How could LEF1 have both "estrogen receptor activity" and "estrogen receptor binding" activity (from the same paper)?
- Curator answer: Insert answer here.
Organism(s) 2
Cellular Component
Biological Process
Questions for ontology curators
Molecular Function
- Based on the definition, shouldn't GO:0003705 "sequence-specific enhancer binding RNA polymerase II transcription factor activity" have some sort of relationship, either is_a or has_part, GO:0035326 "enhancer binding"?