PTHR10373

This is a list of questions that arose while PAINTing PTHR_____.

Questions for MOD curators

Molecular Function

Human LEF1

• Question: Is the IMP to GO:0043027 "caspase inhibitor activity" in PMID 20360943 appropriate? Does the experiment really show a biochemical interaction between LEF1 and caspase, or is reduction of caspase activity aresult of mutating LEF1? If the latter, shouldn't that be a BP annotation?
  • Curator answer: Insert answer here.
• Question: Does LEF1 really bind estrogen, as the GO:0030284 "estrogen receptor activity" IDA from PMID 18794125 implies? How could LEF1 have both "estrogen receptor activity" and "estrogen receptor binding" activity (from the same paper)?
  • Curator answer: Insert answer here.

Questions for ontology curators

Molecular Function

• Based on the definition, shouldn't GO:0003705 "sequence-specific enhancer binding RNA polymerase II transcription factor activity" have some sort of relationship, either is_a or has_part, GO:0035326 "enhancer binding"?