Panther ID:11829: Difference between revisions

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===== 1)  transcription factor activity (GO:0003700) =====
===== 1)  transcription factor activity (GO:0003700) =====


Up-propagation to common ancestor node AN0, the root node, down-propagation to the following Ref Genome proteins:
Up-propagation to common ancestor node AN0 (the root node) down-propagation to the following Ref Genome proteins:


based on many experimental annotations, from yeast to human, that map up to the root node.
based on many experimental annotations, from yeast to human, that map up to the root node.
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===== 1)  nucleus (GO:0005634) =====
===== 1)  nucleus (GO:0005634) =====


Up-propagation to common ancestor node AN0, the root node, down-propagation to the following Ref Genome proteins:
Up-propagation to common ancestor node AN0 (the root node) down-propagation to the following Ref Genome proteins:


based on experimental annotation
based on many experimental annotations, from yeast to human, that map up to the root node.
 
Note that no bacterial species are in this family, so erroneous annotation to 'nucleus' for bacteria is not a concern here.


==== Biological Process:  ====
==== Biological Process:  ====

Revision as of 15:03, 20 August 2009

FOXE1/Forkhead/Forkhead box family

Summary

SourceForge Link

PPOD/OrthoMCL link

Molecular Function

Propagation:

1) transcription factor activity (GO:0003700)

Up-propagation to common ancestor node AN0 (the root node) down-propagation to the following Ref Genome proteins:

based on many experimental annotations, from yeast to human, that map up to the root node.

Cellular Component:

1) nucleus (GO:0005634)

Up-propagation to common ancestor node AN0 (the root node) down-propagation to the following Ref Genome proteins:

based on many experimental annotations, from yeast to human, that map up to the root node.

Note that no bacterial species are in this family, so erroneous annotation to 'nucleus' for bacteria is not a concern here.

Biological Process:

1) Immune response-related annotations:
  • negative regulation of interferon-gamma production (GO:0032689)
  • negative regulation of interleukin-10 production (GO:0032693)
  • negative regulation of interleukin-2 production (GO:0032703)
  • negative regulation of interleukin-4 production (GO:0032713)
  • T cell activation (GO:0042110)
  • negative regulation of interleukin-2 biosynthetic process (GO:0045085)
  • T cell activation (GO:0042110)

Up-propagation to common ancestor node AN175, down-propagation to the following Ref Genome proteins:

RAT_1561201

because of positive experimental annotations to

HUMAN_ENSG00000184481

MOUSE_MGI:1891915

2) negative regulation of cell proliferation (GO:0008285)

Up-propagation to common ancestor node AN27, down-propagation to the following Ref Genome proteins:

RAT_1562112

because of positive experimental annotations to

HUMAN_ENSG00000049768

MOUSE_MGI:1891436


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