Panther ID:11829
FOXE1/Forkhead/Forkhead box family
Summary
Molecular Function
Propagation:
1) transcription factor activity (GO:0003700)
Up-propagation to common ancestor node AN0, the root node, down-propagation to the following Ref Genome proteins:
based on many experimental annotations, from yeast to human, that map up to the root node.
Cellular Component:
1) nucleus (GO:0005634)
Up-propagation to common ancestor node AN20, down-propagation to the following Ref Genome proteins:
RAT_1562112
HUMAN_ENSG000000128573
RAT_1559697
CHICK_769935
DANRE_ZDB-GENE-041203-2
HUMAN_ENSG00000137166
RAT_1311386
DANRE_ZDB-GENE-040426-1338
RAT_1308669
CHICK_416092
because of positive experimental annotations to
HUMAN_ENSG00000049768
MOUSE_MGI:1891436
MOUSE_MGI:1914004
HUMAN_ENSG00000114861 (annotated to nucleolus)
2) nucleus (GO:0005634)
Up-propagation to common ancestor node AN114, down-propagation to the following Ref Genome proteins:
CHICK_421769
DANRE_ZDB-GENE-990708-6
CHICK_374231
DANRE_ZDBJ-GENE-061013-59
DANRE_ENSDARG00000061549
MOUSE_MGI:1891915
CHICK_428703
HUMAN_ENSG00000204060
RAT_1595858
DANRE_ENSDARG00000024619
DANRE_ENSDARG00000055792
DANRE_ZDB-GENE-050116-1
because of positive experimental annotations to
HUMAN_ENSG00000118689
MOUSE_MGI:1890081
RAT_1309196
HUMAN_ENSG000000150907
MOUSE_MGI:1890077
RAT_620283
HUMAN_ENSG00000184481
RAT_1561201
MOUSE_MGI:2676586
Biological Process:
- negative regulation of interferon-gamma production (GO:0032689)
- negative regulation of interleukin-10 production (GO:0032693)
- negative regulation of interleukin-2 production (GO:0032703)
- negative regulation of interleukin-4 production (GO:0032713)
- T cell activation (GO:0042110)
- negative regulation of interleukin-2 biosynthetic process (GO:0045085)
- T cell activation (GO:0042110)
Up-propagation to common ancestor node AN175, down-propagation to the following Ref Genome proteins:
RAT_1561201
because of positive experimental annotations to
HUMAN_ENSG00000184481
MOUSE_MGI:1891915
2) negative regulation of cell proliferation (GO:0008285)
Up-propagation to common ancestor node AN27, down-propagation to the following Ref Genome proteins:
RAT_1562112
because of positive experimental annotations to
HUMAN_ENSG00000049768
MOUSE_MGI:1891436
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