Panther ID:11829
FOXE1/Forkhead/Forkhead box family
Summary
Molecular Function
1) transcription factor activity (GO:0003700) DONE
Up-propagation to common ancestor node AN0 (the root node) down-propagation to many Ref Genome proteins (too many to list, see GAF file) based on many experimental annotations, from yeast to human, that map up to the root node.
2) protein homodimerization activity (GO:0042803) DONE
Up-propagation to common ancestor node AN27, down-propagation to the following Ref Genome proteins:
RAT_1562112
because of positive experimental annotations to
HUMAN_ENSG00000049768
MOUSE_MGI:1891436
Cellular Component:
1) nucleus (GO:0005634) DONE
Up-propagation to common ancestor node AN0 (the root node) down-propagation to many Ref Genome proteins (too many to list, see GAF file) based on many experimental annotations, from yeast to human, that map up to the root node.
No bacterial species are in this family, so erroneous annotation to 'nucleus' for bacteria is not a concern here.
In addition, normally I would be more conservative about propagating a component term like this, especially since there are a scattering of 'cytoplasm' annotations within the tree, but in light of the biology of this family (forkhead transcription factors), I feel comfortable in the propagation of 'nucleus.'
Biological Process:
1) negative regulation of cell proliferation (GO:0008285) DONE
Up-propagation to common ancestor node AN175, down-propagation to the following Ref Genome proteins:
RAT_1561201
because of positive experimental annotations to
HUMAN_ENSG00000184481
MOUSE_MGI:1891915
2) negative regulation of cell proliferation (GO:0008285) DONE
Up-propagation to common ancestor node AN27, down-propagation to the following Ref Genome proteins:
RAT_1562112
because of positive experimental annotations to
HUMAN_ENSG00000049768
MOUSE_MGI:1891436
* negative regulation of interferon-gamma production (GO:0032689) * negative regulation of interleukin-10 production (GO:0032693) * negative regulation of interleukin-2 production (GO:0032703) * negative regulation of interleukin-4 production (GO:0032713) * T cell activation (GO:0042110) * negative regulation of interleukin-2 biosynthetic process (GO:0045085) * T cell activation (GO:0042110)
Up-propagation to common ancestor node AN27, down-propagation to the following Ref Genome proteins:
RAT_1562112
because of positive experimental annotations to
HUMAN_ENSG00000049768
MOUSE_MGI:1891436
4) negative regulation of cell proliferation (GO:0008285) DONE
Up-propagation to common ancestor node AN111, down-propagation to several Ref Genome proteins (see GAF)
because of positive experimental annotations to
HUMAN_ENSG00000184481
MOUSE_MGI:1891915
DROME_FBgn0038197
5) insulin receptor signaling pathway (GO:0008286) DONE
Up-propagation to common ancestor node AN111, down-propagation to several Ref Genome proteins (see GAF)
because of positive experimental annotations to
HUMAN_ENSG00000184481
MOUSE_MGI:1890077
DROME_FBgn0038197
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